SPICE (Simulation Program with Integrated Circuit Emphasis) is a program for electronic circuit design simulation and is one of the most successful academic products. Integrated circuit (IC) designers often use SPICE to check functionality, integrity, and power integrity before physical implementation (i.e., layout design) and tape‐out. Using SPICE to verify IC designs is essential for circuit validation due to the high cost of photolithographic masks and other manufacturing processes. The input to SPICE is a design “netlist,” which is composed of electronic components, such as resistance, transistor, capacitance, and sources. After the SPICE simulation, users can inspect the signal waveform or perform measurements virtually on the probing nodes in the netlist. Nowadays, there are open‐source and commercial SPICE programs for designers or researchers to incorporate SPICE into their projects. Active electronic components are usually described in the device model to reflect the current and voltage behaviors. According to user requirements, SPICE is capable of performing several types of analysis (e.g., DC, AC, transient, and DC sweep) and provides a bridge between time and frequency domain. Facing future challenges, many emerging methods and algorithms have been proposed to address the growing complexity of circuit designs and performance bottlenecks. Additionally, as technology evolves, SPICE continues to add device models to accurately capture the electronic component behavior in advanced technology nodes, such as the TSMC Interface and the Open Model Interface models.