Primary adenocarcinoma of the esophagus arising in a columnar-lined esophagus

Stillman, Alfred E.; Selwyn, Jeffrey I.

doi:10.1007/bf01074941

Cited by 21 publications

(8 citation statements)

References 10 publications

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“…In addition to typical adenomatous areas with dysplastic epithelium and high proliferative activity, there were also tubular structures with non-dysplastic epithelium as well as microcystic areas. The latter changes have been seen in two previously reported esophageal polyps (1,8).…”

Section: Discussionsupporting

confidence: 76%

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Adenoma of the esophagus with intracytoplasmic mucoid bodies

Lindboe¹,

Matre

Nesland

2004

APMIS

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We report a tubular adenoma of the esophagus in a 79-year-old man. The tumour had progressed to an intramucosal carcinoma at follow-up 6 months later. The adenoma displayed a peculiar and heterogeneous histological picture with non-dysplastic and cystic areas alternating with those of a typical tubular adenoma. The tumour revealed a strong and diffuse expression of cytokeratin 7 and basal cell cytokeratin, whereas cytokeratin 20 was focally positive only. The most remarkable finding, however, was the demonstration of intracytoplasmic inclusion-like mucoid bodies of the epithelial cells in a small area of the adenomatous component. These inclusions stained PAS positive and alcian blue negative, and electron microscopy revealed a homogeneous structure without viral-like particles.

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Section: Discussionsupporting

confidence: 76%

“…Adenomas of the esophagus are neoplasms histologically identical to adenomas in other parts of the digestive tract. Most lesions arise in dysplastic Barrett's epithelium and their progression to invasive adenocarcinomas is well documented (1)(2)(3)(4). The first case was reported by Weigert in 1876 as an incidental autopsy finding (5).…”

mentioning

confidence: 99%

Adenoma of the esophagus with intracytoplasmic mucoid bodies

Lindboe¹,

Matre

Nesland

2004

APMIS

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“…8 The expected mortality in our series of patients with Barrett's oesophagus was: number of men incidence in men+incidence in women Although the prognosis of carcinoma of the oesophagus is unfavourable, the incidence is presumably somewhat higher than mortality, so that an annual incidence of 200: 106 could be expected in our series. This would amount to one carcinoma per 5000 patient years.…”

Section: Incidence Of Oesophageal Cancer In the Populationmentioning

confidence: 65%

Adenocarcinoma in Barrett's oesophagus: an overrated risk.

Veen

Dees

Blankensteijn

et al. 1989

Gut

203

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SUMMARY Barrett's oesophagus is a risk factor for the development of oesophageal cancer and for this reason annual endoscopic surveillance has been proposed. In this retrospective study of all patients with Barrett's oesophagus diagnosed in a 12 year period carcinoma had developed in only four patients. The incidence of oesophageal cancer in this series was one in 170 patient years, which means a 30-fold increase compared with the general population. The survival of patients with Barrett's oesophagus was not different, however, from an age and sex matched control population. It is concluded that systematic endoscopic surveillance of patients with Barrett's oesophagus is not indicated.Barrett's oesophagus is a risk factor for the development of oesophageal carcinoma. '-10

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“…Five of the cases contained adenocarcinoma and were treated with esophagectomy [6–10]. In one case, piecemeal polypectomies were performed with biopsy forceps and pathology showed tubular adenomas with low-grade dysplasia.…”

Section: Discussionmentioning

confidence: 99%

Polypoid Dysplasia in Barrett’s Esophagus: Diagnosis, Management, and Very Different Outcomes in Two Consecutive Cases

Murphy

Tofani

Gandhi

et al. 2016

Case Reports in Gastrointestinal Medicine

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Background. Barrett's esophagus is associated with an increased risk of adenocarcinoma. Dysplasia in Barrett's esophagus is a precursor to adenocarcinoma. Rarely, dysplastic polypoid lesions are superimposed on Barrett's esophagus. Most reported cases of polypoid dysplasia in Barrett's esophagus have been advanced on presentation and treated with esophagectomy. We describe two cases of polypoid changes in Barrett's esophagus and treatment with polypectomy followed by radiofrequency ablation. Cases. A 75 yo male presented with esophageal polyps, which on biopsy showed gastric cardia/foveolar mucosa with focal intestinal metaplasia without dysplasia. Biopsy of intervening flat mucosa was consistent with nondysplastic Barrett's esophagus. Extensive hot snare polypectomies were performed followed by RFA. One year later, repeat EGD revealed no evidence of Barrett's esophagus. A 61 yo male presented with esophageal polyps, which on biopsy showed gastric cardia/foveolar mucosa with intestinal metaplasia and foci of low-grade dysplasia. Extensive hot snare polypectomies were performed followed by RFA. At repeat EGD, four months later, an esophageal mass was found. Biopsy of the mass showed invasive adenocarcinoma. The patient was referred for esophagectomy. Conclusion. This case series shows two outcomes, one with successful eradication of dysplasia and the other with disease progression to invasive adenocarcinoma requiring esophagectomy.

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Primary adenocarcinoma of the esophagus arising in a columnar-lined esophagus

Cited by 21 publications

References 10 publications

Adenoma of the esophagus with intracytoplasmic mucoid bodies

Adenoma of the esophagus with intracytoplasmic mucoid bodies

Adenocarcinoma in Barrett's oesophagus: an overrated risk.

Polypoid Dysplasia in Barrett’s Esophagus: Diagnosis, Management, and Very Different Outcomes in Two Consecutive Cases

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