Primary adenoid cystic carcinoma of lung: A case report and review of the literature

Bhattacharyya, Tapesh; Bahl, Amit; Kapoor, Rakesh; Bal, Amanjit; Das, Ashim; Sharma, Sanjiv

doi:10.4103/0973-1482.113399

Cited by 17 publications

(3 citation statements)

References 9 publications

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“…Nearly 8% of young patients in our study were uniquely diagnosed with pulmonary ACC, a histology that is far more frequently identified within tumours of the head and neck [ 27 ]. Salivary gland-type tumours are rarely diagnosed as lung cancers, and historically, mucoepidermoid carcinoma (MEC), fol lowed by ACC and epithelial–myoepithelial carcinoma, is most common [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

A comprehensive comparison between young and older-age non-small cell lung cancer patients at a public referral centre in Delhi, India

Vashistha¹,

Garg²,

Iyer³

et al. 2021

ecancer

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Purpose Given the increasing number of non-small cell lung cancer (NSCLC) patients in India, a comparative analysis between patients under 40 years and those of older age at a major public referral centre would provide insight into the phenotypic patterns of this group. Methods NSCLC patients who were accessioned within the lung cancer clinic database of the Pulmonary Medicine Department at the all India institute of medical sciences – Delhi between 2008 and 2019 were reviewed. Patients 40 years or younger and 60 years or older were selected and categorised as young and older patients, respectively. Baseline clinical characteristics, histologic profiles, treatments administered and survival outcomes were compared between both groups. Results Following the database review, 154 young and 1,058 older patients were selected for inclusion. Clinically, young patients were more often female (26.0% versus 14.5%, p < 0.001), retained a more independent performance status (64.1% versus 45.5%; p < 0.001) and never smoked (63.7 % versus 18.8%, p < 0.001). Regarding disease profiles, young patients were more frequently diagnosed with adenocarcinoma ( p < 0.001) and 12 young patients had adenoid cystic carcinoma. Rates of stage IV disease at presentation were higher among young patients (78.0% versus 63.0%, p < 0.001). Regarding treatment, no differences in systemic therapies administered or survival were identified. Conclusion In India, young NSCLC patients are frequently non-smokers and diagnosed with advanced disease. Despite better performance status, young patients do not share better outcomes. Efforts should be directed towards optimising intensive treatment for young patients.

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Section: Discussionmentioning

confidence: 99%

A comprehensive comparison between young and older-age non-small cell lung cancer patients at a public referral centre in Delhi, India

Vashistha¹,

Garg²,

Iyer³

et al. 2021

ecancer

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“…Taking these data into consideration, a novel therapeutic strategy must be sought for advanced ACCL. The use of imatinib has been reported for one advanced case and achieved a satisfactory effect ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Primary adenoid cystic carcinoma of the lung: Clinicopathological features, treatment and results

et al. 2015

Oncology Letters

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Adenoid cystic carcinoma of the lung (ACCL) is a rare salivary gland-type malignant neoplasm that occurs infrequently as a primary tumor of the airway. Owing to its low incidence, the clinicopathological features, immunohistochemical expression spectrum, treatment and long-term survival have not been fully elucidated. The present study retrospectively assessed the clinical features, immunohistochemical characters, treatment strategy and long-term survival of 34 patients diagnosed with ACCL at the Beijing Chest Hospital, Capital Medical University (Beijing, China) between January 1993 and June 2014. ACCL tended to occur in younger patients, with an approximate male/female ratio of 1:1. The majority of ACCL arose from the central airway. Positive immunochemical staining was found in wide-spectrum keratin (n=17), cytokeratin (CK)7 (n=11), p63 (11/12), S-100 (7/8), vimentin (10/12) and smooth muscle actin (6/9). No staining of thyroid transcription factor-1 (0/14), synaptophysin (0/7), cluster of differentiation 56 (0/7), CK20 (0/4) or chromogranin A (0/4) was observed. In the operable group (n=26), the addition of adjuvant radiotherapy to a positive margin resection (R1 resection) obtained long-term survival times equivalent to that found in patients with a negative margin resection (R0 resection). No significant survival benefit from post-operative radiotherapy was observed in the R0 resection group. For advanced cases, palliative radiotherapy and chemotherapy did not work efficiently. In addition, epidermal growth factor receptor mutation was a rare event in the ACCL patients. The results indicated that surgical resection is the optimal management for ACCL whenever feasible. Adjuvant radiotherapy with R1 resection is able to obtain long-term survival times comparable with those found using an R0 resection. The recommendation of post-operative radiotherapy for all patients with ACCL undergoing resection appears controversial. Owing to a poor response to radiotherapy and chemotherapy, more focus should be placed on the study of advanced ACCL in order to improve overall survival.

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“…The solid histological pattern has been associated with a more aggressive clinical course and early distant metastases, in contrast to the cribriform type which shows a more benign behaviour. [8] The mainstay of therapy is surgery. Our patient probably had post obstructive pneumonia and an empyema as a result of the tumour in the left upper lobe.…”

Section: Adenoid Cystic Carcinomamentioning

confidence: 99%

A series of patients with unusual lung cancers with unusual presentations

Maphanga

2019

Afr J Thorac Crit Care Med

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Primary adenoid cystic carcinoma of lung: A case report and review of the literature

Cited by 17 publications

References 9 publications

A comprehensive comparison between young and older-age non-small cell lung cancer patients at a public referral centre in Delhi, India

A comprehensive comparison between young and older-age non-small cell lung cancer patients at a public referral centre in Delhi, India

Primary adenoid cystic carcinoma of the lung: Clinicopathological features, treatment and results

A series of patients with unusual lung cancers with unusual presentations

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