Primary Adenomyoepithelioma of the Sellar Region

Rychlý, Boris; Kazakov, Dmitry V.; Daniš, Dušan; Szép, Zoltán; Michal, Michal

doi:10.1097/pas.0b013e3181f0ac1b

Cited by 7 publications

(8 citation statements)

References 12 publications

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“…They present with signs and symptoms of mass effect. Previous reports documented various histotypes including pleomorphic adenoma, low‐grade adenocarcinoma, low‐grade acinic cell carcinoma, adenoid cystic carcinoma, myoepithelioma and adenomyoepithelioma . Similar to our patient, a conclusive diagnosis could only be reached after excluding an extra‐sellar tumor origin.…”

Section: Discussionsupporting

confidence: 82%

Primary epithelial‐myoepithelial carcinoma of the pituitary gland

et al. 2020

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Primary salivary gland‐like tumors of the sella are rare and often challenging to diagnose. They reportedly derive from serous and mucinous glands that remain trapped in the infundibulum during embryogenesis. We report a 68‐year‐old man who presented with partial left third cranial nerve palsy, visual loss in the left eye without visual field defects, headache, weight loss and reduced muscle bulk. Neuroimaging studies demonstrated a solid and cystic, avidly enhancing lesion expanding the pituitary fossa and extending to the left cavernous sinus. The patient underwent craniotomy and the tissue removed showed features of epithelial‐myoepithelial carcinoma similar to the salivary gland, skin and breast counterpart. No primary tumor was found outside the sella. The lesion behaved aggressively despite radio‐chemotherapy and the patient died 22 months from the onset. The tumor showed a novel TP53 in‐frame deletion (Gly154del) while no variants were found in H‐RAS hotspot regions (codons 12, 13 and 61). Our report expands the spectrum of salivary gland‐like tumors primarily occurring in the sella and emphasizes the need for specialist review of rare, non‐neuroendocrine tumors of the pituitary and sella regions.

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Section: Discussionsupporting

confidence: 82%

Primary epithelial‐myoepithelial carcinoma of the pituitary gland

et al. 2020

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“…AME is commonly documented in the breast literature. On the other hand, extramammary AME is extremely uncommon and has been rarely reported in the tonsil, 11 sellar region, 12 and skin. [1][2][3][4][5][6][7] Including the current case report, a total of 8 examples of primary cutaneous AME have been recorded to date in the English literature (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Primary Cutaneous Adenomyoepithelioma Ex Spiradenoma With Malignant Histologic Features, Epithelial-Myoepithelial Carcinoma Type: A First Case Report With Molecular Studies

et al. 2019

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Adenomyoepithelioma is an extremely rare primary cutaneous neoplasm. Although there is ample evidence on the existence of malignant adenomyoepithelioma in the breast, a malignant counterpart in the skin has not been documented. We report a primary cutaneous adenomyoepithelioma (pcAME) with malignant features arising from a spiradenoma in a 39-year-old female patient. The tumor was solid-cystic in appearance and entirely located in the subcutaneous tissue. Histologically, the tumor displayed foci of adenomatous changes and adenomyoepitheliomatous hyperplasia adjacent to a minute spiradenoma. Gradual increase of architectural complexity, cytologic atypia, mitotic activity, and infiltrative growth were observed in a significant portion of the neoplasm, indicative of transformation to adenomyoepithelioma and subsequently low- to high-grade salivary-type epithelial-myoepithelial carcinoma (EMCA). The intimate dual populations of ductal and myoepithelial cells were highlighted by a panel of immunohistochemical stains in all different components of the tumor. Molecular studies revealed a PIKCA3 mutation, a genetic aberration that has been documented in EMCA, particularly of breast origin. The current case documents for the first time a pcAME with malignant features arising from a spiradenoma and suggests adenomyoepithelioma ex spiradenoma as a possible tumorigenesis pathway of this rare cutaneous tumor.

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“…However, midline ectopic salivary gland rests are extremely rare. Small salivary gland-type rests are reported in association with the pituitary gland and may rarely give rise to salivary tumors in the sella turcica or skull base [7,8]. Although no ectopic salivary tissue, normal or neoplastic, has been reported in the midline of the neck including the isthmus, we propose that seromucinous salivary-type glandular tissue may have migrated from the foramen cecum in the primitive oral cavity with the median anlage to the isthmus and may have given rise to the isthmic PA in this patient.…”

Section: Discussionmentioning

confidence: 99%