Primary adenosquamous carcinoma of the endometrium with glassy cell features. A diagnostic pitfall as a very rare tumour type in the endometrium

Abstract

Summary Primary adenosquamous carcinoma of the endometrium with glassy cell features (ASCGCF) is an extremely rare entity and to date, 16 cases of this entity have been reported in the literature. ASC-GCF is an aggressive histological subtype of cervical carcinoma with rapid growth and early metastases; however, very little is known about those originating from the endometrium as they are limited to only a few case reports. Herein, we report a case of primary adenosquamous carcinoma of the endometrium with extensive glassy cell features which posed a major diagnostic challenge by mimicking many entities with its histological diversity.

The importance of molecular classification of endometrial carcinomas in clinical practice: how to apply it and difficulties in application

“…However, there is a morphological overlap, especially in high-grade ECs, which even complicates the distinction between the two main clinically significant histological categories; endometrioid or non-endometrioid. Furthermore, it has been clearly seen that patient management models based solely on histological subtypes are inadequate, both for the very rare and little-known EC subtypes ( 2 , 3 , 4 ), and for the more common and well-known EC subtypes, which may show prognostic inter-patient heterogeneity.…”