Primary Adenovillous Carcinoma of the Bladder

Abstract

Two cases of primary adenovillous carcinoma of the bladder are presented: one in a normally placed bladder and the other in an exstrophied bladder. The close association of these 2 neoplasms with coexistent cystitis glandularis would seem to support the possible precancerous nature of the latter entity. The remarkable similarity of these neoplasms to villous adenocarcinomas of the rectum is also described, a finding which may reflect the close embryologic origin of the rectum and bladder neck. A brief review of the classification of vesical adenocarcinomas is also given.

Villous adenoma of the urinary bladder

“…The former does not have the well‐formed villous structures that are typical of the villous adenoma. In the latter, the epithelium is pseudostratified, and the nuclei are enlarged, crowded and hyperchromatic, features that are not present in cystitis glandularis 8 …”

“…The coexistence of glandular metaplasia with invasive adenocarcinoma of the urothelium is a frequent finding. Therefore, it has been suggested that glandular metaplasia (cystitis glandularis), in some cases, might evolve into adenocarcinoma 8,9 . However, at least one study did not confirm that intestinal metaplasia was a strong risk factor for the development of a malignant neoplasm of the urinary bladder 10 .…”

“…Therefore, it has been suggested that glandular metaplasia (cystitis glandularis), in some cases, might evolve into adenocarcinoma. 8,9 However, at least one study did not confirm that intestinal metaplasia was a strong risk factor for the development of a malignant neoplasm of the urinary bladder. 10 In four cases, among the published case reports there was coexistence of cystitis glandularis with the villous adenoma.…”

Mucinous adenocarcinoma with superficial stromal invasion and villous adenoma of urachal remnants: a case report

“…1 2 "Malignant transformation of a urachal villous adenoma is a possible mechanism for the histogenesis of primary adenocarcinoma of the bladder" Villous adenoma is rarely found outside the large bowel, and villous glandular neoplasms are uncommon in the urinary bladder. [3][4][5][6][7][8][9] Urachal villous adenoma is very rare. In the report by Eble et al, 7 16 cases were identified in the literature published up to 1986.…”

The contribution of urethrocystoscopy to evaluation of lower urinary tract dysfunction in women

“…These included an intravesical suture, a urethral diverticulum, 2 cases of papillary transitional-cell carcinoma and 2 cases of cystitis glandularis. Cystitis glandularis is a glandular metaplasia associated with chronic irritation of the bladder mucosa and adenovillous carcinoma, and is a possible precursor of the latter [9][10][11].…”