Primary adrenal Ewing’s sarcoma family of tumors with tumor thrombus of the inferior vena cava: a case report

Abstract

Background Ewing’s sarcoma is a malignant neoplasm that mainly occurs in skeletal tissue but can rarely arise in soft tissues. Recently, small round cell tumors (including Ewing’s sarcoma) caused by chromosomal translocations have been collectively termed Ewing’s sarcoma family of tumors. We report a rare case of primary adrenal Ewing’s sarcoma family of tumors with tumor thrombus. Case presentation A 22-year-old Asian woman was referred to our hospital with a left retroperitoneal tumor 19 cm in diameter. Tumor thrombus was identified from the left adrenal vein to the inferior vena cava, infiltrating the right atrium. Total tumor excision with left adrenalectomy, nephrectomy, and thrombectomy was performed under hypothermic circulatory arrest, followed by seven courses of adjuvant chemotherapy. The patient has shown no signs of recurrence as of 26 months postoperatively. Conclusion Radical surgery combined with systemic chemotherapy may contribute to good prognosis in patients with primary adrenal Ewing’s sarcoma family of tumors.

Abdominal distention, immunopositivity, and aggressive nature: A rare Ewing's sarcoma of the adrenal gland

“…Patients with totally resected tumors for localized ESFT had a good prognosis, even in cases of rapid local spread. Those with incomplete resection can have a poor prognosis, and such cases must be treated with radiotherapy [11] . Chemotherapy for adrenal ES mirrors the regimen used for skeletal ES involving Vincristine, Doxorubicin, and Cyclophosphamide (VAC) alternated with Ifosfamide and Etoposide (IE).…”