Primary adult soft tissue sarcomas: analysis of 294 patients

Abstract

We retrospectively analyzed 294 patients with primary soft tissue sarcoma followed between 1996 and 2002 in Ankara Oncology Hospital. There were 170 male and 124 female patients with the age range of 16-80 years. The primary tumor was in the extremity in 72.9% of the patients. We determined lung metastasis in 102 (85%) out of the 120 patients as distant metastasis. The most common adult sarcomas were liposarcoma (16.3%), malignant mesenchymal tumor (MMT) (13.9%), malignant fibrous histiocytoma (MFH) (11.2%), rhabdomyosarcoma (10.2%) and synovial sarcoma (10.2%). Seventeen patients (5.3%) had grade 1 tumor, 143 patients (52.2%) had grade 2 tumor, and 112 patients (41.4%) had grade 3 tumor. In 45 patients (15.3%), the grade of the tumors is unknown. The tumor size was 0 to <5 cm in 54 cases (19.4%), 5-10 cm in 117 cases (41.9%) and >10 cm in 108 cases (38.7%). In 15 cases (5.1%), tumor size was unknown. Ninety-five patients (32.4%) were treated with adjuvant chemotherapy, and 125 patients (42.7%)) were treated with palliative chemotherapy. Prognostic factors influencing the overall survival were tumor size, grade, adjuvant radiotherapy and chemotherapy. Adjuvant radiotherapy had influence on disease-free survival. While tumor grade and size showed a significant value for predicting local recurrence, grade, localization of tumor, adjuvant chemotherapy and radiotherapy had an impact on metastasis development. The 1-year overall survival for all patients was 73.4%, 3-year overall survival was 51.8%, and 5-year overall survival was 45.1%.

Adult Soft Tissue Sarcoma Local Recurrence After Adjuvant Treatment Without Resection of Core Needle Biopsy Tract

“…This was equal to or lower compared with previous studies (22%-49%) [4,22,25,36,37,43,51,55,56,58,65]. Margin status did not have a statistically negative effect on the rate of metastases; however, given the small number of R1 margins, a conclusion cannot be drawn from this either.…”

“…There were five local recurrences (9%) among our patients, which was lower than numerous studies that evaluated local recurrences in patients with soft tissue sarcomas (13%-39%) [4,22,25,36,37,43,51,55,56,58,65]. Some of these studies included all tumor grades, superficial and deep tumors as well as trunk wall and retroperitoneal tumors.…”

“…Historically reported rates of local recurrence of soft tissue sarcomas range from 13% to 29% and metastases from 22% to 49% [4,22,25,36,37,43,51,55,56,58,65]. The addition of radiation to the wide resection of sarcomas improves local recurrence rates from 19% to 30% in certain studies, even in patients with microscopically positive margins [3,12,16,27,30,52,53,60,62].…”

Retrospective Analysis of 498 Primary Soft Tissue Sarcomas in a Single Turkish Centre

“…Visceral and retroperitoneal sarcomas show propensity to metastasize tol iver and peritoneum (Alkis et al, 2011). In our study the most common site for metatasis lung and than liver.…”

Luteinizing hormone, sex steroids and extracorporeal circulation – A promising link to treat retroperitoneal sarcomas. A reconsideration of cancer treatment

“…Although there are discordant views on tumor microvessel density as a prognostic factor for sarcomas [17,18], less than 100 mm tumor diameters are associated with higher overall survival rates [19,20], although the radicality rate has not been correlated to sarcoma dimension. The peak incidence of retroperitoneal sarcomas coinciding with patient menopause and andropause and the higher survival in female patients than in men reported in some studies, including ours, create a possible link between retroperitoneal sarcomas and sex steroid levels.…”