Primary aldosteronism in general practice

Chan, N N; Isaacs, A J

doi:10.1016/s0140-6736(05)70723-6

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…Primary Aldosterone disease is a major cause of secondary hypertension and characterized by overproduction of the mineralocorticoid hormone aldosterone [ 1 , 2 ]. The inappropriately high production of aldosterone can lead to suppression of plasma renin, sodium retention, hypertension, cardiovascular damage, and potassium excretion [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Receptor, an Important Transcription Factor Associated with Aldosterone-Producing Adenoma

Bi¹,

Li²,

Du³

et al. 2013

PLoS ONE

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ObjectiveTo explore the endocrine mechanisms of aldosterone-producing adenoma (APA) by using the microarray expression profiles of normal and APA samples. MethodsThe gene expression profile GSE8514 was downloaded from Gene Expression Omnibus database, including samples from normal adrenals (n = 5) and APAs (n = 10). The differentially expressed genes (DEGs) were identified by samr package and endocrine DEGs were obtained according to Clinical Genome Database. Then, functional enrichment analysis of screened DEGs was performed by DAVID (Database for Annotation, Visualization and Integrated Discovery). Finally, a regulatory network was constructed to screen endocrine genes related with adrenal dysfunction and pathway enrichment analysis for the constructed network was performed. ResultsA total of 2149 DEGs were identified including 379 up- and 1770 down-regulated genes. And 26 endocrine genes were filtered from the DEGs. Furthermore, the down-regulated DEGs are mainly related to protein kinase cascade, response to molecule of bacterial origin, response to lipopolysaccharide, cellular macromolecule catabolic process and macromolecule catabolic process, while the up-regulated DEGs are related with regulation of ion transport. The target genes of VDR (vitamin D receptor), one of the three endocrine genes differentially expressed in the regulatory network, were endocrine genes including CYP24A1 (25-hydroxyvitamin D-24-hydroxylase) and PTH (parathyroid hormone). Three pathways may be associated with APA pathogenesis including cytokine-cytokine receptor interaction, pathways in cancer and autoimmune thyroid disease. ConclusionThe VDR is the most significant transcription factor and related endocrine genes might play important roles in the endocrine mechanisms of APA.

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Section: Introductionmentioning

confidence: 99%

Vitamin D Receptor, an Important Transcription Factor Associated with Aldosterone-Producing Adenoma

Bi¹,

Li²,

Du³

et al. 2013

PLoS ONE

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Gammagrafía suprarrenal cortical con frenación y supresión de la frenación con dexametasona en el estudio del hiperaldosteronismo primario

López

Castell‐Conesa

Montaner

et al. 2004

Revista Española de Medicina Nuclear

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Is aldosterone the missing link in refractory hypertension?: aldosterone-to-renin ratio as a marker of inappropriate aldosterone activity

2002

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Use of the random aldosterone-to-renin ratio (ARR) as a reliable marker of inappropriate aldosterone activity has led to primary aldosteronism (PA) being increasingly diagnosed in hypertensive patients. At least 10% of hypertensives have been found to have PA, the majority of whom presumably have bilateral adrenal hyperplasia or idiopathic hyperaldosteronism as an aetiology for PA. Whilst these patients clearly have excess aldosterone activity, they have in common many features that are found in hypertensive patients in general, amongst which include heightened angiotensin II adre-

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Primary aldosteronism in general practice

Cited by 3 publications

References 4 publications

Vitamin D Receptor, an Important Transcription Factor Associated with Aldosterone-Producing Adenoma

Vitamin D Receptor, an Important Transcription Factor Associated with Aldosterone-Producing Adenoma

Gammagrafía suprarrenal cortical con frenación y supresión de la frenación con dexametasona en el estudio del hiperaldosteronismo primario

Is aldosterone the missing link in refractory hypertension?: aldosterone-to-renin ratio as a marker of inappropriate aldosterone activity

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