Primary amelanotic rhabdoid melanoma of the forehead

Fernández‐Vega, Iván; Santos‐Juanes, Jorge; Fresno-Forcelledo, Manuel F

doi:10.1111/bjd.14382

Cited by 7 publications

(9 citation statements)

References 8 publications

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“…In the literature, only ten cases of rhabdoid primary melanomas have been reported so far. Although rhabdoid differentiation is associated with poor prognosis in other malignancies, metastatic spread was described in only four of these ten cases ( Table 2 ) [ 3 , 4 , 7 , 10 ]. Here, we report four additional cases of rhabdoid primary melanoma, of which three showed metastatic spread in terms of cutaneous metastases already being present at primary diagnosis ( Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

“…Typical immunohistochemical characteristics are the (at least partial) loss of melanocytic markers and positivity for the mesenchymal markers vimentin or desmin ( Figure 1 b). Most cases of rhabdoid MM described in the literature refer to the rhabdoid differentiation of metastases, while only a limited number of primary melanomas with rhabdoid histopathologic features have been published [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. Therefore, little is known about the common histopathologic and immunohistochemical characteristics of these rare dedifferentiated primary tumors and their prognosis.…”

Section: Introductionmentioning

confidence: 99%

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PRAME Expression as Helpful Immunohistochemical Marker in Rhabdoid Melanoma

et al. 2022

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Background: Rhabdoid melanoma is a rare variant of malignant melanoma with characteristic cytomorphologic features. Due to the potential loss of conventional melanocytic markers, histopathologic diagnosis is often challenging. We hypothesize that immunostaining for PReferentially expressed Antigen in MElanoma (PRAME) might have the potential to uncover the melanocytic origin of these dedifferentiated tumors. Methods: Four cases of rhabdoid primary melanomas were assessed by immunohistochemistry for expression of PRAME and conventional melanocytic markers. Immunohistochemical expression patterns were analyzed in the rhabdoid primaries and, if available, associated metastases. Results: All four cases of rhabdoid primary melanomas showed a strong nuclear positivity for PRAME, while the expression of conventional melanocytic markers S100, MART-1, SOX-10 and HMB-45 was variable between the analyzed cases. Conclusions: In summary, we report four cases of rhabdoid primary melanoma with high to intermediate expression of PRAME despite the partial and variable loss of other melanocytic markers. Hence, PRAME might facilitate the recognition of this highly aggressive entity to avoid misdiagnosis due to histopathologic pitfalls.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

PRAME Expression as Helpful Immunohistochemical Marker in Rhabdoid Melanoma

et al. 2022

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“…29,88,89 Melanocytic markers such as S100, Sox-10, and p75NGFR are helpful in challenging cases. 84 Presence of rhabdoid differentiation does not seem to be an independent prognostic criterion in melanoma, with most cases usually presenting as nodular lesions at an advanced stage. 86…”

Section: Rhabdoid Melanomamentioning

confidence: 90%

“…8,83 According to the available literature, primary rhabdoid melanoma seems to be exceedingly uncommon, with only 9 cases reported so far, whereas development of a rhabdoid morphology seems to be a more frequent occurrence in metastatic melanoma. [84][85][86] Indeed, rhabdoid differentiation in melanoma was first described in 1992 by Bittesini et al 85 in a metastasis.…”

Section: Rhabdoid Melanomamentioning

confidence: 96%

“…Suggested clinical differential diagnoses included basal cell carcinoma, adnexal neoplasms, and infundibular cyst. 84,86 Histopathologically, this variant of melanoma is characterized by a variable proportion of rhabdoid cells, with the latter constituting the only cell population in approximately half of reported cases. 87 The hypereosinophilic quality of the cytoplasm of rhabdoid melanocytes seems to be the result of exuberant accumulation of intermediate filaments.…”

Section: Rhabdoid Melanomamentioning

confidence: 99%

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Uncommon Histopathological Variants of Malignant Melanoma. Part 2

Saggini

Cota

Lora

et al. 2019

The American Journal of Dermatopathology

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Despite new horizons opened by recent advances in molecular pathology, histological evaluation still remains the diagnostic gold standard regarding cutaneous melanocytic neoplasms. Several histological variants of melanoma have been described, and their knowledge is crucial for accurate diagnosis and classification of cases with unusual clinico-pathological features. Uncommon histological variants of melanoma have been described based on a broad constellation of features, including architectural pattern, stromal alterations, cytological attributes, and other morphological properties. This review is aimed at providing an extensive discussion of unusual but distinctive histopathological variants of melanoma.

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