2008
DOI: 10.1016/j.fertnstert.2007.11.064
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Primary amenorrhea revealing an occult progesterone-secreting ovarian tumor

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Cited by 14 publications
(8 citation statements)
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“…Progesterone-producing tumors are extremely rare. Previous studies have reported cases with primary amenorrhea revealing an occult progesterone-secreting ovarian Leydig cell tumor and granulosa cell tumors [6–8]. To our knowledge, only three other cases have reported adrenal tumors producing progesterone [911] (Table 2).…”
Section: Discussionmentioning
confidence: 92%
See 1 more Smart Citation
“…Progesterone-producing tumors are extremely rare. Previous studies have reported cases with primary amenorrhea revealing an occult progesterone-secreting ovarian Leydig cell tumor and granulosa cell tumors [6–8]. To our knowledge, only three other cases have reported adrenal tumors producing progesterone [911] (Table 2).…”
Section: Discussionmentioning
confidence: 92%
“…Adrenal vein sampling is a highly accurate method used to localize ALD-secreting adenomas. Catheterization of ovarian veins has been used to identify the source of progesterone [6] and selective adrenal venous sampling together with ovarian venous sampling have primarily been used in the localization of occult androgen-secreting ovarian tumors [1215]. We have also reported the diagnosis of ovarian ACTH-independent ectopic Cushing syndrome with the help of combined ovarian and adrenal venous sampling [16].…”
Section: Discussionmentioning
confidence: 99%
“…It is well known that progesterone acts at the hypothalamic level and inhibits GNRH pulse frequency (20). More recently, it has been shown that progesterone also acts directly at the pituitary level (20,21,22). Little is known about the effects of androgens on gonadotropin secretion in women.…”
Section: Discussionmentioning
confidence: 99%
“…The fact that a complete fur recovery and a normalization of behaviour were observed after surgical removal of the neoplastic testicle substantiates the suspicion that the reported clinical signs were a consequence of hormonal imbalances related to the cryptorchid testicle. Maybe the diagnosed interstitial cell hyperplasia, which could have led to an increased androgen and/or progesterone production, may have caused the alopecia and increased sexual behaviour in the present case (5,16,24). This assumption is supported by the prominent positive reaction of hyperplastic interstitial cells for Melan-A.…”
Section: Discussionmentioning
confidence: 51%