Primary amyloidosis of the bladder mimicking bladder tumor

Abstract

Amyloidosis is a benign, non-neoplastic disease characterized by the deposition of extracellular fibrillar protein in tissues or organs, which may be systemic or localized. Primary amyloidosis localized in the bladder is very rare in the literature and may mimic bladder cancer at presentation. A 31-year-old female patient consulted to our clinic and was diagnosed with primary bladder amyloidosis; intravesical dimethyl sulfoxide (DMSO) therapy was started. To the best of our knowledge, this patient represents the fourth case in the Turkish medical literature.

Cases of a Borderline Pathology That Can Mimic Bladder Cancer: Primary Amyloidosis of Urinary Bladder

“…Amyloidosis is a heterogeneous disease characterised by accumulation of amyloid protein in one single (localised) or multiple organs or tissues (systemic). It can affect any organ in the urinary tract, but primary localised bladder amyloidosis is uncommon with less than 90 reported cases (1,2,4). In etiology, chronic cystitis and inflammation is blamed for accumulation of amyloid precursors in the bladder (6).…”

“…Amyloidosis consists of extracellular deposition of amyloid, in one or more body sites. In the urinary tract, amyloid accumulation is usually seen in renal pelvis, ureters, urinary bladder and even penis (1,2,3,4). Primary amyloidosis localised in the bladder is a very rare entity which was first described by Solomin in 1987 (5).…”

A Retrospective Analysis of Cases with Localized Amyloidosis of the Vesicula Seminalis and the Ductus Deferens

“…Lokalize amiloidozis, amiloid birikiminin tek bir dokuya sınırlı kalması sonucu gelişen ve lokalize bir kitle oluşturması nedeniyle de klinik olarak maligniteleri taklit edebilen non-neoplastik bir hastalıktır. Ürogenital sistemde yerleşen lokalize amiloidozis de başta mesane olmak üzere, daha nadir olarak prostat, renal pelvis, vezikula seminalis, duktus deferens ve üreter tutulumu gözlenmektedir 3,4 .…”