Primary anaplastic large-cell lymphoma, ALK1 negative, of the liver: A case report

Tsavari, Aikaterini; Koulia, Kalliroi; Skafida, E; Myoteri, Despoina; Zisi, Anna; Grammatoglou, Xanthippi; Vasilakaki, Thivi

doi:10.13172/2052-0077-2-2-466

Cited by 1 publication

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“…[3] Various extranodal locations, although less commonly involved than in ALK-positive ALCL, have been reported. [4][5][6] However, pyrexia of unknown origin and sepsis have only rarely been described as unusual presentations of extranodal ALK-negative ALCL. [7] While ALK-positive ALCL is characterized by recurrent translocations involving ALK gene permitting easy diagnosis by anti-ALK immunohistochemistry, the same is not true for ALK-negative ALCL, as it lacks well-characterized genetic alterations and specific immunophenotypic features.…”

Section: Discussionmentioning

confidence: 99%

ALK-Negative Anaplastic Large-Cell Lymphoma Diagnosed on Liver Biopsy in a Child Presenting with Nonresolving Pyrexia

Kakkar

Sharma

Das

et al. 2019

Indian Journal of Medical and Paediatric Oncology

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ALK-negative anaplastic large-cell lymphoma (ALCL) is a rare non-Hodgkin lymphoma occurring in adulthood. We report a case of a 13-year-old boy who presented with a 6-month history of fever with jaundice and pancytopenia. Computed tomography abdomen showed multiple hypodense lesions in the liver. Bone marrow biopsy revealed necrotizing granulomas. The patient was treated with antitubercular treatment but failed to show a response. Liver biopsy performed subsequently showed features of ALK-negative ALCL. Extranodal involvement in ALK-negative ALCL can have unusual clinical presentations. This case highlights the utility of timely tissue diagnosis in patients with nonresolving pyrexia and organ lesions on imaging.

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