Primary and acquired multidrug-resistant tuberculosis: Predictive factors for unfavorable treatment outcomes in Rio de Janeiro, 2000–2016

Abstract

Objective. To identify clinical and demographic factors associated with unfavorable treatment outcomes in patients with primary and acquired multidrug-resistant tuberculosis (MDR-TB) in Rio de Janeiro State. Methods. Retrospective cohort study using data on 2 269 MDR-TB cases in 2000–2016. Factors associated with unsuccessful, loss to follow-up, and death outcomes in patients with primary and acquired resistance were investigated with bivariate and multivariate regression. Results. Primary resistance was 14.7% among MDR-TB cases. The unfavorable outcomes proportion was 30.3% in the primary resistance group and 46.7% in the acquired resistance group. There were significant differences in demographic and clinical characteristics between the two groups. Proportionally, the group with primary resistance had more cases among women (46.4% vs. 33.5% in the acquired resistance group), Caucasians (47.3% and 34%), and those with ≥8 years of schooling (37.7% and 27.4%). Extensively drug-resistant TB patients had 12.2-fold higher odds of unsuccessful outcome than MDR-TB patients, and comorbidities had 2-fold higher odds in the primary resistance group. Extensively drug-resistant TB had 5.43-fold higher odds in the acquired MDR-TB group. Bilateral disease and <8 years of schooling were associated with unsuccessful outcome in both groups. Being an inmate had 8-fold higher odds of loss to follow-up in the primary resistance group. Culture conversion by the sixth month was a protective factor for all outcomes. Conclusions. Primary resistance cases of MDR-TB constitute a different transmission reservoir, which is related to other chronic diseases associated with higher acquisition of TB. The poor results observed in Rio de Janeiro State can contribute to increasing the transmission of primary MDR-TB, thus favoring drug resistance.

Brazilian cohort study of risk factors associated with unsuccessful outcomes of drug resistant tuberculosis

“…Having lesions detected in both lungs suggests a late diagnosis and this factor was related to failure and death, as was also found in other studies [ 18 , 23 , 24 ]. In the study period, the GeneXpert MTB/RIF® was just being implemented in Brazil and culture was taken for 26% and 42% for new and retreatment cases, respectively [ 25 ].…”

“…Low education was associated with LFU and death. Several studies have already associated education with adherence to sensitive and MDR-TB treatment [ 10 , 16 – 18 ]. The significance of this finding can be extrapolated to their conditions, as education is recognized as a proxy of socioeconomic status [ 19 ].…”

Factors Associated With the Occurrence of Primary Multidrug-Resistant Tuberculosis in Medan

“…Primary multi-drug resistant tuberculosis (MDR-TB) is a distinct reservoir of transmission, which is associated with other chronic diseases associated with higher transmission of MDR-TB. Primary MDR-TB is a new case of TB including patients never treated for TB, patients in treatment with a basic regimen, evolving to failure and subsequent diagnosis of drug-resistant TB, and patients in treatment with a basic regimen, who underwent culture and a drug sensitivity test at the beginning of treatment with subsequent diagnosis of drug-resistant TB (1). Tuberculosis is an infectious disease that is very dangerous and can lead to death.…”

“…MDR-TB requires longer treatment time and considerable costs. MDR-TB cases raise concerns about direct transmission of resistant mycobacterium tuberculosis bacteria, leading to primary resistance in infected people (1).…”

Trends in primary multidrug-resistant tuberculosis in the State of Rio de Janeiro: a retrospective study conducted during 2000-2019

“…The study found significant differences in the demographic and clinical characteristics between the two groups. Proportionally, the group with primary drug resistance had predominantly female patients (46.4% vs. 33.5% in the acquired resistance group), Caucasians (47.3% vs. 34%), and those with schooling for ≥8 years (37.7% vs. 27.4%) 13 . These results emphasize that the primary cases of MDR-TB constitute another reservoir of transmission and are less related to lower socioeconomic levels 13 .…”