Primary and novel approaches for colon targeted drug delivery – A review

Tiwari, Gaurav; Tiwari, Ruchi; Wal, Pranay; Wal, Ankita; Kumar, Awani

doi:10.5138/ijdd.2010.0975.0215.02006

Cited by 25 publications

(15 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[3,4] There are various primary approaches for achieving colon targeting, including delivering of drug as a prod rug, by delaying the drug release, or by microbial way. [5,6] However, these approaches have many disadvantages or have some limitations that enforce over new colon developed system which are better than former ones. Colonic drug delivery is useful to improve treatment of disease depending on the diurnal rhythm such as asthma and arthritis.…”

Section: Introductionmentioning

confidence: 98%

Formulation and characterization of calcium chloride guar gum microsphere of theophylline

Verma¹,

Jain²,

Shukla³

2012

Chron Young Sci

View full text Add to dashboard Cite

Aim:The aim of the present work was to formulate and characterize an effective colonic drug delivery system for nocturnal asthma based on the time-and pH-dependent system. Materials and Methods: The microsphere of calcium chloride guar gum was prepared by using theophylline. It was prepared by the method of emulsification and coating was done by the method of solvent evaporation with the pH-sensitive eudragit polymers. The prepared microsphere was characterized by particle size, surface morphology, entrapment efficiency, and degree of swelling. Results: The drug release was confirmed by the in vitro drug release in various pH progression medium and dissolution medium. The controlled release of theophylline after a lag time was achieved with developed formulation for colon drug delivery. Conclusion: The pH-dependent solubility behavior of eudragit and gelling properties of guar gum are found to be responsible for delaying the release.

show abstract

Section: Introductionmentioning

confidence: 98%

Formulation and characterization of calcium chloride guar gum microsphere of theophylline

Verma¹,

Jain²,

Shukla³

2012

Chron Young Sci

View full text Add to dashboard Cite

show abstract

“…The presence of different pH values along the gastrointestinal tract (GI tract) is a considerable challenge for drugs to reach the target sites accurately [5,6]. Many strategies related to colon-specific drug delivery were introduced; these strategies include the covalent linkage between drugs and polymers (prodrug), pH, time and microbial responsive strategies osmotic pressure-controlled drug delivery system [7][8][9] and the use of multiparticulate systems, such as microspheres and nanospheres [10].…”

Section: Introductionmentioning

confidence: 99%

Biocompatible disulphide cross-linked sodium alginate derivative nanoparticles for oral colon-targeted drug delivery

Ayub

Chiu

Yusuf

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

View full text Add to dashboard Cite

The application of layer-by-layer (LbL) approach on nanoparticle surface coating improves the colonspecific drug delivery of insoluble drugs. Here, we aimed to formulate a self-assembled cysteaminebased disulphide cross-linked sodium alginate with LbL self-assembly to improve the delivery of paclitaxel (PCX) to colonic cancer cells. Cysteamine was conjugated to the backbone of oxidized SA to form a core of self-assembled disulphide cross-linked nanospheres. P3DL was selected for PCX loading and fabricated LbL with poly(allylamine hydrochloride) (PAH) and poly(4-styrenesulfonic acid-co-maleic acid) sodium salt (PSSCMA) resulting from characterization and drug release studies. P3DL-fabricated PCX-loaded nanospheres (P3DL/PAH/PSSCMA) exhibited an encapsulation efficiency of 77.1% with cumulative drug release of 45.1%. Dynamic light scattering analysis was reported at 173.6 ± 2.5 nm with polydispersity index of 0.394 ± 0.105 (zeta potential¼ À58.5 mV). P3DL/PAH/PSSCMA demonstrated a pH-dependent swelling transition; from pH 1 to 7 (102.2% increase). The size increased by 33.0% in reduction response study after incubating with 10 mM glutathione (day 7). HT-29 cells showed high viabilities (86.7%) after treatment with the fabricated nanospheres at 0.8 mg/mL. Cellular internalization was successful with more than 70.0% nanospheres detected in HT-29 cells. Therefore, this fabricated nanospheres may be considered as potential nanocarriers for colon cancer-targeted chemotherapeutic drug delivery. ARTICLE HISTORY

show abstract

“…Creation of suitable environment for the growth of colonic microorganisms, storage reservoir of faecal contents, and expulsion of the contents of the colon at an appropriate time and absorption of potassium and water from the lumen are the major functions of the human colon. About 2000ml of fluid enters the colon through the ileocecal valve from which more than 90% of the fluid is absorbed showing that the absorptive capacity of colon is very high [15][16][17] .…”

Section: Anatomy and Physiology Of Colonmentioning

confidence: 99%

Untitled

2017

IJPSR

View full text Add to dashboard Cite

Now a day's world health organisation encourage, recommends and promotes traditional, herbal remedies in health care science, because these drugs are easily available at low cost and are safe but herbal medicines are not a simple task since many factor influence biological efficacy and reproducible therapeutic effect. These day's colonic diseases are commonly seen and needs lifelong medical attention. Because of safety, herbal medicines can play vital role in the treatment of colonic diseases. Various natural therapies, available for the treatment of colonic diseases like ulcerative colitis, Intestinal bowel syndrome, colon cancer, etc. It is possible to improve the effect of these herbal medicines by targeting to the colon. This article review a detailed study about various pharmaceutical approaches used for colon targeting such as tablet, capsules, microparticles, micro-sponges, lyposomes, etc. with herbal drugs and their effects. Effects of different process and formulation parameters on colon targeted drug delivery system are also discussed in following article.

show abstract

Primary and novel approaches for colon targeted drug delivery – A review

Cited by 25 publications

References 29 publications

Formulation and characterization of calcium chloride guar gum microsphere of theophylline

Formulation and characterization of calcium chloride guar gum microsphere of theophylline

Biocompatible disulphide cross-linked sodium alginate derivative nanoparticles for oral colon-targeted drug delivery

Untitled

Contact Info

Product

Resources

About