Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature

Tsuyuguchi, Sayuru; Sakamoto, Kazuhiko; Kinoshita, Yasuyuki; Kolakshyapati, Manish; Takayasu, Takeshi; Usui, Satoshi; Takano, Motoki; Yonezawa, Ushio; Taguchi, Akira; Amatya, Vishwa Jeet; Takeshima, Yukio; Kurisu, Kaoru; Yamasaki, Fumiyuki

doi:10.1016/j.wneu.2019.10.074

Cited by 13 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We present a single-institution case series of 14 pediatric patients with intracranial teratoma confirmed on surgical pathology and treated between 2006 and 2021. The few case series on intracranial teratoma establish its low prevalence among brain tumors, which ranges from 1 to 7% for children [12‒17]. Demographic and tumor characteristics of our cohort are reflected in other studies.…”

Section: Discussionmentioning

confidence: 77%

See 1 more Smart Citation

Treatment Course and Outcomes of Intracranial Teratomas in Pediatric Patients: A Retrospective 15-Year Case Series Study

Wu,

Jin,

Vogel

et al. 2023

Pediatr Neurosurg

View full text Add to dashboard Cite

Introduction There is no standard treatment paradigm for intracranial teratomas, a rare subset of primary intracranial nongerminomatous germ cell tumors (NGGCT), which comprise less than 1% of pediatric brain tumors. This case series retrospectively analyzes treatment and outcomes of pediatric intracranial teratomas from a single institution. Methods Authors reviewed a comprehensive pathology database at Stanford’s Lucile Packard Children’s Hospital for intracranial teratomas in pediatric patients treated from 2006-2021. Demographics, treatment and clinical course were analyzed. Results Among 14 patients, median follow-up time was 4.6 years and mean age at diagnosis was 10.5 years. Ten had elevated tumor markers and underwent chemotherapy as initial treatment for NGGCT. Ultimately, these patients all required surgery for progressive or residual disease. Two patients did not undergo radiation. After biopsy or resection, eight patients had pure mature teratoma; five had mixed germ cell tumor with teratoma component; and one had immature teratoma. The patient with immature teratoma died during chemotherapy from septic shock. No patients experienced recurrence. Common sequelae were endocrine (42.8%) and eye movement (50.0%) abnormalities. Discussion/Conclusion We highlight the variable treatment course and outcome for pediatric patients with intracranial teratomas. Elevated tumor markers at presentation, along with imaging findings, favor chemotherapy initiation for presumed NGGCT. Resection of residual tumor is recommended even if tumor markers return to normal. Prognosis remains excellent; no patients had recurrence with a median follow-up of 4.6 years.

show abstract

Section: Discussionmentioning

confidence: 77%

“…For these patients with tumors with mixed components, radiation is helpful as adjuvant therapy. In addition, the “growing teratoma syndrome” phenomenon refers to patients with enlarging tumor elements despite chemo- or radiotherapy [12, 16]. A few patients in our series demonstrated such tumor growth, requiring salvage surgery.…”

Section: Discussionmentioning

confidence: 96%

Treatment Course and Outcomes of Intracranial Teratomas in Pediatric Patients: A Retrospective 15-Year Case Series Study

Wu,

Jin,

Vogel

et al. 2023

Pediatr Neurosurg

View full text Add to dashboard Cite

show abstract

“…The biological behavior of these tumors is variable, and they have an intermediate prognosis between mature teratomas and high-risk germ cell tumors [ 1 , 25 ]. Similarly, finding immature teratoma on biopsy has been significantly associated with an increased risk of developing growing teratoma syndrome (GTS) [ 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Mature Teratoma at the Lumbar Spinal Cord: A Case Report and Literature Review

Zavala-Romero,

Villanueva-Castro,

Datta-Banik

et al. 2024

Cureus

View full text Add to dashboard Cite

Mature spinal teratoma is a rare type of germ cell tumor that arises from any of the three germ cell layers (ectoderm, mesoderm, and endoderm) and consists of differentiated tissues and structures that reflect the cellular organization and morphology of normal adult tissues. It has the ability to grow independently and cause compressive symptoms when found in this rare location. In this article, we present the case of a 29-year-old male patient with the onset of neurological symptoms beginning with pelvic limb paresthesias and progressing to back pain. Magnetic resonance imaging (MRI) revealed a tumor at L1-L4, which was resected by laminotomy, and histopathology revealed a mature intradural teratoma. Fortunately, this histologic type had a good prognosis for our patient, who had a significant clinical improvement. A systematic review was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology with PubMed and Google Scholar to find similar case reports and to summarize the main features of this disease, which contributes to the understanding of its diagnostic presentation, treatment, and prognosis, improving clinical practice in the management of similar cases. The rarity of this condition, together with its wide clinical heterogeneity and prognosis, underscores the importance of a thorough evaluation of cases of intramedullary lesions, where the consideration of uncommon diseases in the differential diagnosis should be highlighted.

show abstract

“…Growing teratoma syndrome is considered rare, but a 5% frequency of intracranial growing teratoma syndrome has been reported [10]. Classically, growing teratoma syndrome is thought to be a histologically benign mature teratoma, and growth is mainly attributed to the enlargement of the multicystic component of mature teratoma [11].…”

Section: Discussionmentioning

confidence: 99%

Successful Multimodal Treatment of Intracranial Growing Teratoma Syndrome with Malignant Features

Satake,

Natsumeda,

Satomi

et al. 2024

Current Oncology

View full text Add to dashboard Cite

Molecular analysis of the growing teratoma syndrome has not been extensively studied. Here, we report a 14-year-old boy with a growing mass during treatment for a mixed germ cell tumor of the pineal region. Tumor markers were negative; thus, growing teratoma syndrome was suspected. A radical resection via the occipital transtentorial approach was performed, and histopathological examination revealed a teratoma with malignant features. Methylation classifier analysis confirmed the diagnosis of teratoma, and DMRT1 loss and 12p gain were identified by copy number variation analysis, potentially elucidating the cause of growth and malignant transformation of the teratoma. The patient remains in remission after intense chemoradiation treatment as a high-risk germ cell tumor.

show abstract

Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature

Cited by 13 publications

References 30 publications

Treatment Course and Outcomes of Intracranial Teratomas in Pediatric Patients: A Retrospective 15-Year Case Series Study

Treatment Course and Outcomes of Intracranial Teratomas in Pediatric Patients: A Retrospective 15-Year Case Series Study

Mature Teratoma at the Lumbar Spinal Cord: A Case Report and Literature Review

Successful Multimodal Treatment of Intracranial Growing Teratoma Syndrome with Malignant Features

Contact Info

Product

Resources

About