Primary and recurrent regional metastases for lateralized oral cavity squamous cell carcinoma

Contrera, Kevin J.; Huang, Andrew T.; Tang, Chad; Roberts, Dianna B.; Myers, Jeffrey N.; Weber, Randal S.; Lai, Stephen Y.; Williams, Michelle D.; El-Hallal, Maria; Jacob, Denny; Shenson, Jared A.; Zafereo, Mark

doi:10.1016/j.suronc.2022.101804

Cited by 8 publications

(2 citation statements)

References 54 publications

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“…This study is the first to evaluate the laterality of LVI in PCa and its correlation with the lateralization of nodal involvement. While the impact of LVI on lateralized LNI has been explored in various malignancies such as thyroid, oropharyngeal, and rectal cancers, the specific investigation of LVI laterality in the setting of PCa has not been previously undertaken [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. Existing studies have primarily focused on the broader question of whether LVI influences lateralized LNI, omitting an in-depth exploration of LVI laterality itself [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Lymphovascular Invasion with Lymph Node Metastases in Prostate Cancer—Lateralization Concept

Karwacki,

Gurwin,

Jaworski

et al. 2024

Cancers

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Background. Lymphovascular invasion (LVI) is a vital but often overlooked prognostic factor in prostate cancer. As debates on lymphadenectomy’s overtreatment emerge, understanding LVI laterality gains importance. This study pioneers the investigation into PCa, aiming to uncover patterns that could influence tailored surgical strategies in the future. Methods. Data from 96 patients with both LVI and lymph node invasion (LNI) were retrospectively analyzed. All participants underwent radical prostatectomy (RP) with modified-extended pelvic lymph node dissection (mePLND). All specimens underwent histopathological examination. The assessment of LVI was conducted separately for the right and left lobes of the prostate. Associations within subgroups were assessed using U-Mann–Whitney and Kruskal–Wallis tests, as well as Kendall’s tau-b coefficient, yielding p-values and odds ratios (ORs). Results. Out of the 96 patients, 61 (63.5%) exhibited exclusive left-sided lymphovascular invasion (LVI), 24 (25.0%) had exclusive right-sided LVI, and 11 (11.5%) showed bilateral LVI. Regarding nodal involvement, 23 patients (24.0%) had LNI solely on the left, 25 (26.0%) exclusively on the right, and 48 (50.0%) on both sides. A significant correlation was observed between lateralized LVI and lateralized LNI (p < 0.001), particularly in patients with right-sided LVI only. LN-positive patients with left-sided LVI tended to have higher pT stages (p = 0.047) and increased odds ratios (OR) of bilateral LNI (OR = 2.795; 95% confidence interval [CI]: 1.231–6.348) compared to those with exclusive right-sided LVI (OR = 0.692; 95% CI: 0.525–0.913). Conclusions. Unilateral LVI correlates with ipsilateral LNI in PCa patients with positive LNs, notably in cases of exclusively right-sided LVI. Left-sided LVI associates with higher pT stages and a higher percentage of bilateral LNI cases.

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Section: Discussionmentioning

confidence: 99%

Association of Lymphovascular Invasion with Lymph Node Metastases in Prostate Cancer—Lateralization Concept

Karwacki,

Gurwin,

Jaworski

et al. 2024

Cancers

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“…Surgery is the primary treatment of OSCC, followed by cisplatin-based chemotherapy and/or radiotherapy depending on pathologic features and individualized risk of recurrence. Regional recurrence is the most common cause of failure after treatment of oral carcinoma ( 2 , 3 ). Despite advancements in surgical techniques and adjuvant therapies, the 5-year overall survival rate hovers between 45-50%, contingent upon the stage and metastasis status of the disease ( 4 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

Radiomic biomarkers of locoregional recurrence: prognostic insights from oral cavity squamous cell carcinoma preoperative CT scans

Ling,

Alexander,

Molitoris

et al. 2024

Front. Oncol.

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IntroductionThis study aimed to identify CT-based imaging biomarkers for locoregional recurrence (LR) in Oral Cavity Squamous Cell Carcinoma (OSCC) patients.MethodsComputed tomography scans were collected from 78 patients with OSCC who underwent surgical treatment at a single medical center. We extracted 1,092 radiomic features from gross tumor volume in each patient’s pre-treatment CT. Clinical characteristics were also obtained, including race, sex, age, tobacco and alcohol use, tumor staging, and treatment modality. A feature selection algorithm was used to eliminate the most redundant features, followed by a selection of the best subset of the Logistic regression model (LRM). The best LRM model was determined based on the best prediction accuracy in terms of the area under Receiver operating characteristic curve. Finally, significant radiomic features in the final LRM model were identified as imaging biomarkers.Results and discussionTwo radiomics biomarkers, Large Dependence Emphasis (LDE) of the Gray Level Dependence Matrix (GLDM) and Long Run Emphasis (LRE) of the Gray Level Run Length Matrix (GLRLM) of the 3D Laplacian of Gaussian (LoG σ=3), have demonstrated the capability to preoperatively distinguish patients with and without LR, exhibiting exceptional testing specificity (1.00) and sensitivity (0.82). The group with LRE > 2.99 showed a 3-year recurrence-free survival rate of 0.81, in contrast to 0.49 for the group with LRE ≤ 2.99. Similarly, the group with LDE > 120 showed a rate of 0.82, compared to 0.49 for the group with LDE ≤ 120. These biomarkers broaden our understanding of using radiomics to predict OSCC progression, enabling personalized treatment plans to enhance patient survival.

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Using texture analysis of ultrasonography images of neck lymph nodes to differentiate metastasis to non-metastasis in oral maxillary gingival squamous cell carcinoma

Kawashima,

Hagimoto,

Abe

et al. 2025

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathol

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Primary and recurrent regional metastases for lateralized oral cavity squamous cell carcinoma

Cited by 8 publications

References 54 publications

Association of Lymphovascular Invasion with Lymph Node Metastases in Prostate Cancer—Lateralization Concept

Association of Lymphovascular Invasion with Lymph Node Metastases in Prostate Cancer—Lateralization Concept

Radiomic biomarkers of locoregional recurrence: prognostic insights from oral cavity squamous cell carcinoma preoperative CT scans

Using texture analysis of ultrasonography images of neck lymph nodes to differentiate metastasis to non-metastasis in oral maxillary gingival squamous cell carcinoma

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