Primary and secondary adenocarcinomas associated with anal fistulae

Yamada, Kyoko; Miyakura, Yasuyuki; Koinuma, Koji; Horie, Hisanaga; Lefor, Alan Kawarai; Yasuda, Yoshikazu; Fukushima, Noriyoshi; Oyama, Yusuke; Nemoto, Yuta; Azuma, Hiroshi

doi:10.1007/s00595-013-0629-y

Cited by 11 publications

(3 citation statements)

References 20 publications

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“…As Rosser first established in 1934, these cancers are often associated with a prolonged history of chronic fistula disease greater than 10 years [ 2 ]. Recently, however, cases where the fistula has been present for less time are being reported, in some cases being diagnosed after 2 months [ 3 ]. In this particular case, mucinous adenocarcinoma was diagnosed only 4 months after the fistula.…”

Section: Discussionmentioning

confidence: 99%

Extensive Resection for Treatment of Locally Advanced Primary Mucinous Adenocarcinoma Arising From Fistula-in-Ano

Hulme-Moir

Herd

et al. 2021

Ann Coloproctol

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We report a case of a 66-year-old male who presented with a locally advanced primary mucinous adenocarcinoma arising from a fistula-in-ano. The presentation was typical for perianal sepsis and fistula-in-ano with anal pain and chronic discharge. Initial treatment with fistula debridement and seton were performed. Subsequent review of histology revealed underlying adenocarcinoma, while MRI imaging showed local invasion into the prostate. The patient received neoadjuvant chemoradiotherapy followed by pelvic exenteration to maximise the chance of achieving cure. Features of this case are discussed together with its implications, including treatment guidelines and typical MRI findings.

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Section: Discussionmentioning

confidence: 99%

Extensive Resection for Treatment of Locally Advanced Primary Mucinous Adenocarcinoma Arising From Fistula-in-Ano

Hulme-Moir

Herd

et al. 2021

Ann Coloproctol

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“…Anal adenocarcinoma is a rare malignancy of the anal canal 52 . Owing to its rarity, the optimal treatment strategy for anal adenocarcinoma has not been established, there is very little evidence to guide treatment, and most are treated like low rectal cancers.…”

Section: Special Casesmentioning

confidence: 99%

Recent advances in the management of anal cancer

Symer

Yeo

2018

F1000Res

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Anal cancer is a rare condition, although its incidence has been increasing over the past several decades, particularly in women. The majority of anal cancers are squamous cell cancers and are linked with human papilloma virus (HPV) infection. Recent work in HPV basic science has delineated the mechanism by which the virus leads to the development of anal cancer. With widespread availability of an HPV vaccine since 2006, vaccination has become an important strategy for anal cancer prevention. However, in the US, there remain no guidelines for anal cancer screening. Treatment of anal cancer is dictated largely by accurate staging, which is generally accomplished with a combination of physical exam, magnetic resonance imaging, computed tomography, and positron emission tomography. Chemoradiation remains the mainstay of treatment for most patients, with surgery reserved for salvage therapy. Recent trials have identified the optimal use of available chemotherapeutics. Exciting developments in immune therapies targeting HPV oncoproteins as well as therapeutic vaccines may soon dramatically change the way patients with anal cancer are managed.

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“…Perianal fistula associated adenocarcinoma has also been reported in Crohn's disease [4]. Yamada K.et al [5] there is a need for special attention to be given to the similar conditions associated with malignant disease. for Andrew T. study [6] showed that fistulae result from perianal Crohn's disease, tuberculosis, or neoplasm.…”

Section: Introductionmentioning

confidence: 97%

Study the Incidence of Fistula- in- Ano in Subsequent to Anal Abscess

Dhahir¹

2020

DJM

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Background: The Fistula disease is considered common surgical case in the surgical wards of the Baquba teaching hospital, and consider as a complication of the anorectal abscess. Objective: To investigate the incidence of cases that infect with fistula in ano in subsequent to different types of anorectal abscesses. Patients and Methods: This study performed in the Baquba teaching hospital in a period from January 2016 until Jun 2018 including 216 patients (124 male and 92 female); all patients were included in the study . Samples of the patients classified into three groups according to the type of management. Results: The results show that the high incidence of fistula in ano is appearing in patients associated with hemorrhoids 8.84%, and high percent in patients who had a perianal abscess (63.48%) Regarding the distribution of cases according to age and sex, a low percentage of cases appear in age (1-10) with 6.45% and 2.18% in males and females respectively. While the highest percentage appears in the males at age (21-30) with 37.11% and in females is at the age (11-20) with 29.35%. And by the chi-square value for males is 16.37 and for females is 9.94 in a significant value of p=0.01 and p=0.05 respectively. Conclusion: Fistula in ano can be associated with cases have hemorrhois, and more present with patients who have a perianal abscess, and the early drainage of the abscess can prevent development of the fistula. Keywords: Fistula, Ano, Anorectal abscess, Internal anal sphincter

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Primary and secondary adenocarcinomas associated with anal fistulae

Abstract: Anal fistulae are commonly seen in the coloproctology clinic, but special attention to similar conditions associated with malignant disease is needed.

Cited by 11 publications

References 20 publications

Extensive Resection for Treatment of Locally Advanced Primary Mucinous Adenocarcinoma Arising From Fistula-in-Ano

Extensive Resection for Treatment of Locally Advanced Primary Mucinous Adenocarcinoma Arising From Fistula-in-Ano

Recent advances in the management of anal cancer

Study the Incidence of Fistula- in- Ano in Subsequent to Anal Abscess

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