Primary and secondary angiosarcoma of the breast: The Mayo Clinic experience

Scow, Jeffrey S.; Reynolds, Carol; Degnim, Amy C.; Petersen, Ivy A.; Jakub, James W.; Boughey, Judy C.

doi:10.1002/jso.21497

Cited by 124 publications

(83 citation statements)

References 68 publications

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“…Women aged between 20 and 50 who do not have a previous history of epithelial breast cancer are most commonly affected 6 . In our cohort, the median age at diagnosis was 53.5 years, the age range was 24 to 83 years and older patients overmatched.…”

Section: Discussionmentioning

confidence: 99%

“…It is most commonly seen in younger patients, women in their thirties and forties 4 . Clinically, women with pas usually present with swelling, a sensation of fullness, and exponential growth within the breast 5,6 . The prognosis for pas is generally poor, and the diagnosis may be delayed because of possible unusual clinical presentation and its rarity.…”

Section: Introductionmentioning

confidence: 99%

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Primary Angiosarcoma of the Breast—Series of 11 Consecutive Cases—A Single-Centre Experience

et al. 2018

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Angiosarcomas of the breast are rare parenchymal malignancies of the chest wall. Surgery is the main treatment modality with chemotherapy and radiotherapy used in case of recurrence. With generally unfavourable prognosis and lack of clear treatment guidelines due to its rarity and scarcity of available data, angiosarcoma of the breast is a challenging clinical situation for both oncologist and patient. We present here the results of a series of 11 consecutive primary angiosarcoma cases treated at our institute between 2000 and 2015.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Primary Angiosarcoma of the Breast—Series of 11 Consecutive Cases—A Single-Centre Experience

et al. 2018

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“…Primary breast angiosarcoma is more frequent in young women (20 to 50 years) with no previous cancer history or other known risk factors [1,2]. Between 6 and 12 % of primary breast angiosarcomas are diagnosed during pregnancy or shortly after, suggesting hormonal involvement.…”

Section: Discussionmentioning

confidence: 99%

Primary Angiosarcoma of Breast: A Case Report

Raju

Mahajan

Rehmani

et al. 2014

Indian J Surg Oncol

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Primary breast sarcomas are rare entities. These malignant tumors originate from mesenchymal glandular breast tissue and account for <1 % of all breast cancer cases. Angiosarcomas are rare malignant tumors that arise from endothelial cells lining vascular channels. Most angiosarcomas are secondary to radiotherapy treatments for breast cancer or to an arm lymphoedema subsequent to a modified radical mastectomy. Primary angiosarcomas are rare and account for 0.04 % of all malignant breast tumors. Keywords Breast . Primary angiosarcoma Case reportA 22 year old female presented with 4 months history of awareness of painless progressive lump in left breast. There was no history of previous breast surgery or irradiation. On examination there was a large lump occupying all quadrants of left breast with skin nodules and plaques and pinkish blue discoloration (Fig. 1a). Examination of axilla was unremarkable. Trucut biopsy from the lump was suggestive of vascular channels dissecting the stroma. Vascular channels were lined by plump endothelial cells with extensive haemorrhage and focal mitotic activity. Morphology suggested possibility of angiosarcoma. Immunohistochemistry (IHC) was positive for CD 31 and CD 34. Based on these findings provisional diagnosis of angiosarcoma of left breast was kept. Chest radiograph, ultrasonography of abdomen and F-18 bone scan were negative for metastatic disease. Patient underwent total mastectomy with level I axillary lymph node dissection with latissimus dorsi myocutaneous flap reconsruction. On gross examination tumour was well circumscribed measuring 17× 14×7 cm. Histopathologic examination (HPE) showed large gaping vascular channels lined by endothelial cells, focally arranged as lobular aggregates with atypical mitosis (5-6 per 10 high power fields) and focally congested vascular channels (Fig. 1b). All margins were free of tumour. All 7 nodes resected were negative for malignancy. IHC was negative for cytokeratin and positive for CD 31 (Fig.1c) and CD 34. IHC was negative for estrogen and progesterone receptors. More than 75 % of bulk of tumour was formed by well differentiated pattern but there were significant foci showing solid areas with marked pleomorphism and mitotic activity. So, diagnosis of primary intermediate grade angiosarcoma of breast was made. Patient received 50 Gy radiation therapy to chest wall (2 Gy per fraction over 5 weeks) followed by three cycles of adriamycin and ifosfamide based chemotherapy. Following third cycle of chemotherapy she complained of bone pains. F-18 bone scan was done and it was suggestive of multiple bone metastasis while contrast enhanced computed tomogram of chest, abdomen and pelvis was negative for metastasis. DiscussionPrimary breast angiosarcoma is more frequent in young women (20 to 50 years) with no previous cancer history or other known risk factors [1,2]. Between 6 and 12 % of primary breast angiosarcomas are diagnosed during pregnancy or shortly after, suggesting hormonal involvement. However, cases reported to display ...

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“…Scow et al presented a primary angiosarcoma occurring in the form of a tumor, and the secondary as redness of the skin [15].…”

Section: Discussionmentioning

confidence: 99%

“…However, there is a controversy over the surgical treatment. Some authors believe that the excision of the tumor with a 1 cm margin is sufficient, while others offer 3 cm [14], but most of them propose a simple mastectomy without axillary lymph node dissection, due to the fact that most angiosarcoma tumors disseminate through the blood system [2,11,14,15].…”

Section: Discussionmentioning

confidence: 99%

Primary breast angiosarcoma in postmenopausal woman: case study and the literature review

Jońska-Gmyrek¹,

Bakuła-Zalewska²,

Gałecki³

et al. 2013

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SummaryA case of an 83-year-old female patient, who was admitted to the Centre of Oncology in Warsaw because of the right breast tumor, is presented. There was no exposure to prior irradiation. In two biopsies of the lesion, its malignant nature was not confirmed. Breast tumor removal with wide surgical margins was performed. As a result of the examination, angiosarcoma was confirmed histologically. Given the result, a simple right breast amputation was performed. External beam radiotherapy and chemotherapy, due to the rapid local recurrence and distant metastases, were also performed. The patient died after 20 months of the initial diagnosis because of the disease progression.Key words: breast angiosarcoma, pathology, symptoms, diagnosis, treatment. StreszczeniePrzedstawiono przypadek 83-letniej kobiety, która zgłosiła się do Centrum Onkologii w Warszawie z powodu guza piersi prawej. W wywiadzie nie stwierdzono wcześniejszej ekspozycji na promieniowanie jonizujące. W trakcie dwukrotnie wykonanych biopsji nie potwierdzono złośliwego charakteru zmiany. Przeprowadzono wycięcie guza piersi z szerokim marginesem. W wyniku badania histopatologicznego potwierdzono utkanie naczyniakomięsaka. Ze względu na uzyskany wynik przeprowadzono prostą amputację prawej piersi. W związku z wczesnym nawrotem miejscowym i przerzutami odległymi, pacjentka została zakwalifikowana do radioterapii i chemioterapii. Chora zmarła po upływie 20 miesięcy od rozpoznania choroby z powodu progresji.Słowa kluczowe: naczyniakomięsak piersi, patologia, objawy, diagnoza, leczenie.

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Primary and secondary angiosarcoma of the breast: The Mayo Clinic experience

Abstract: Primary angiosarcoma occurs in younger patients than secondary and more frequently presents with a mass. Mastectomy is the mainstay of treatment for breast angiosarcoma. Breast angiosarcoma is a rare malignancy with poor long-term prognosis.

Cited by 124 publications

References 68 publications

Primary Angiosarcoma of the Breast—Series of 11 Consecutive Cases—A Single-Centre Experience

Primary Angiosarcoma of the Breast—Series of 11 Consecutive Cases—A Single-Centre Experience

Primary Angiosarcoma of Breast: A Case Report

Primary breast angiosarcoma in postmenopausal woman: case study and the literature review

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