Most coronaviruses share a similar structure and infection pathway; thus, one can expect the similar infection mechanisms for SARS-CoV-2. 4 Coronaviruses could invade the brain via the cribriform plate close to the olfactory bulb and the olfactory epithelium. We could expect some structural changes in the olfactory bulb that were not observed in this case. However, it is important to assess the volume of the olfactory bulb that might be, at this this stage, too subtle to be detected on MRI results. Moreover, Yao et al 5 have reported that the volume of the olfactory bulb is decreased in patients with postinfectious olfactory loss and is inversely related to the duration of olfactory loss.Recently Ligget et al 6 described an expression of the olfactory receptor family on central cortical neurons, vascular smooth muscle, and upper and lower airway epithelium. Because SARS-CoV-2 infects the human respiratory epithelial cells through an impairment of the angiotensin-converting enzyme 2 receptor, we believe that this olfactory receptor family could also be selectively impaired. 1 To our knowledge, this is the first report of a patient with COVID-19 presenting essentially with an olfactory function loss. As reported by the French Society of ENT (https://www.snorl. org/category-acces-libre/alerte-anosmie-covid-19-20-mars-2020/), we believe that the association of a sudden and complete olfactory function loss, without nasal obstruction in a patient with other symptoms, such as cough or fever, should alert the clinician to suspect SARS-CoV-2 infection.