Primary and secondary malignant involvement of gynaecological organs at radical cystectomy for bladder cancer: Review of literature and retrospective analysis of 360 cases

Salem, Hosni; El-Mazny, Akmal

doi:10.3109/01443615.2012.693980

Cited by 23 publications

(9 citation statements)

References 38 publications

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“…reported the outcome of 29 women undergoing radical cystectomy with internal genital organ preservation, and they noted that none of them had late ovarian, vaginal or uterine recurrence at the last follow-up. [ 6 ]…”

Section: Discussionmentioning

confidence: 99%

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Orthotopic genital sparing radical cystectomy in pre-menopausal women with muscle-invasive bladder carcinoma: A prospective study

et al. 2016

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Introduction:Invasive cancer bladder is a life-threatening disease that is best treated with radical cystectomy and a suitable urinary diversion. The aim of this study was to evaluate the oncological outcome, voiding and sexual functions after genital sparing radical cystectomy with orthotopic bladder reconstruction in pre-menopausal women with bladder cancer.Materials and Methods:18 pre-menopausal women who underwent radical cystectomy and orthotopic urinary diversion with preservation of genital organs were included for this study. The patients were followed-up clinically and radiologically to assess their oncological outcome in addition to their voiding and sexual function.Results:Mean age of the patients was 37.8 years, and the median follow-up after surgery was 70 months. One patient was lost to follow-up at 12 months post-operatively. The surgery was completed as planned in all patients, with a mean operative time of 290 min and an average blood loss of 750 mL. 14 patients were able to void satisfactorily, being continent day and night, while four patients needed clean intermittent catheterization. Sexual life remained unchanged in 15 cases, while three patients reported dysparunea. Till the last follow-up, there was no local recurrence while distant metastases were detected in three cases, two of whom died.Conclusions:Genital sparing cystectomy is a valid option for managing carefully selected women with muscle-invasive bladder cancer with good functional and sexual outcomes.

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Section: Discussionmentioning

confidence: 99%

“…[ 3 ] Genital-sparing cystectomy is based upon studies confirming that genital organ involvement in women with bladder cancer is rare. [ 4 5 6 ]…”

Section: Introductionmentioning

confidence: 99%

Orthotopic genital sparing radical cystectomy in pre-menopausal women with muscle-invasive bladder carcinoma: A prospective study

et al. 2016

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“…Metastasis of urothelial carcinoma to the uterus is very rare. 23,24 Metastasis of colorectal cancer to the genital tract is described. 25 No information is available on the risk for Crohn diseaseYrelated metastases.…”

Section: Discussionmentioning

confidence: 99%

Co-Operative Radical Pelvic Surgery

Saadeh

Cheema

McCormick

et al. 2015

International Journal of Gynecological Cancer

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This study describes a new technique for reconstructing the vagina and vestibule after radical extirpative surgery for urological and anorectal malignancy. The uterus is always excised when exenterative surgery is performed for gynecological cancer. The use of the uterus as a graft gives the gynecologic oncologist/reconstructive surgeon a role in the multidisciplinary team with urologists when the anterior vaginal wall and vestibule are excised and with the anorectal surgeons when the posterior vaginal wall and perineum are excised for nongynecological cancers. In some such cases, only the anterior or posterior wall of the vagina may be excised, leaving a healthy full-length, one-third, or half-circumference vaginal sleeve. A myoserosal flap is raised from the in situ uterus. The ectocervix is excised, and the adnexa are detached or excised. The uterus is opened to generate a hexagonal flap. The endometrium and endocervix are excised/ablated with electrocautery. The flap is advanced to the edge of the remaining anterior vestibule or reconstituted perineum. The serosal surface of the uterus forms the new wall of the vagina and undergoes metaplastic transformation to squamous epithelium within 3 months. The very satisfactory anatomical and functional outcome means that this technique merits further evaluation.

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“…Ten percent of the patients had urethral involvement (all had TCC). During late follow up of 50 patients (included two cases with uterine preservation, and in all cases, at least one ovary was preserved), no single ovarian or uterine recurrence was reported [14,15].…”

Section: Definition and Rationale Of Genital-sparing Radical Cystectomentioning

confidence: 99%

Genital Organs-Sparing Radical Cystectomy in Female Patients with Muscle Invasive Urothelial Carcinoma of the Bladder

Salem¹

2017

Bladder Cancer - Management of NMI and Muscle-Invasive Cancer

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There has been considerable interest in urethral-sparing cystectomy and preservation of the gynecological tract to maintain continence mechanism, sexual function, and reproductive function in young patients who undergo radical cystectomy for muscle-invasive bladder cancer and this new technique gained acceptance in many centers. The issue of oncological safety of a urethra and anterior vaginal wall-sparing cystectomy in selected patients has been addressed by several authors. The chapter will discuss the following items: (

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Primary and secondary malignant involvement of gynaecological organs at radical cystectomy for bladder cancer: Review of literature and retrospective analysis of 360 cases

Cited by 23 publications

References 38 publications

Orthotopic genital sparing radical cystectomy in pre-menopausal women with muscle-invasive bladder carcinoma: A prospective study

Orthotopic genital sparing radical cystectomy in pre-menopausal women with muscle-invasive bladder carcinoma: A prospective study

Co-Operative Radical Pelvic Surgery

Genital Organs-Sparing Radical Cystectomy in Female Patients with Muscle Invasive Urothelial Carcinoma of the Bladder

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