Background: Chondroblastoma (CB) is a rare, primary, benign bone tumor that common affects men aged 15-20 years. It is usually detected in the epiphysis of the long bones, such as the proximal femur, humerus, and tibia. However, CB is extremely rare in the patella, especially in combination with secondary aneurysmal bone cyst (ABC). In fact, this complicated condition can be easily confused with other common bone tumors of the patella. Case presentation: We have presented here the case of a 30-year-old man who was suffering from the anterior knee pain for the past 6 months that got aggravated since the past 2 weeks. Osteolytic bone destruction in the patella could be detected in both his X-ray and computed tomography (CT) examinations, while the magnetic resonance imaging (MRI) detected a fluid level. Accordingly, secondary ABC was presumed. We diagnosed the condition as giant cell tumor (GCT) with secondary ABC and accordingly performed curettage inside the focus region by autogenous bone grafting in accordance with the patient's medical history, physical manifestations, results of physical and ancillary examinations, and the disease characteristics. However, the in- and postsurgical outcomes indicated that the patient’s histopathology was consistent with that of typical CB, suggesting a definitive error in diagnosis. Accordingly, the patient was finally diagnosed with patella CB along with secondary ABC.Conclusions: Past studies have demonstrated that the 3 commonest bone tumors affecting the patella are GCT, CB, and ABC. We believe that the condition of patella GCT and CB accompanied with secondary ABC can be easily misdiagnosed. Performing incision biopsy or excision biopsy and conducting histological examination may be the most effective approach to identify and distinguish among these diseases.