2022
DOI: 10.14740/wjon1542
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Primary Angiosarcoma of the Spleen: An Aggressive Neoplasm

Abstract: Primary tumors of the spleen are rare, with an incidence rate of about 0.1%. These tumors could be benign, usually asymptomatic, or malignant which are usually symptomatic with abdominal pain being the most common symptom. Lymphoid neoplasms are the most common primary splenic tumors. Primary angiosarcoma is one of the extremely rare malignant vascular neoplasms of the spleen, which carries a dismal prognosis. It constitutes almost 7.4% of all primary malignant splenic neoplasms and is well known as an aggress… Show more

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Cited by 6 publications
(9 citation statements)
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“…Additional staining for human herpes virus 8 is recommended to exclude Kaposi sarcoma. In early stages, mitotic rate and tumor size can be of prognostic value [1]. Only in our third case was the Ki-67proliferation index elevated, which is consistent with the aggressive nature of PAS in a metastatic setting.…”
Section: Discussionsupporting
confidence: 83%
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“…Additional staining for human herpes virus 8 is recommended to exclude Kaposi sarcoma. In early stages, mitotic rate and tumor size can be of prognostic value [1]. Only in our third case was the Ki-67proliferation index elevated, which is consistent with the aggressive nature of PAS in a metastatic setting.…”
Section: Discussionsupporting
confidence: 83%
“…On MRI, hypo-and hyperintense regions can be found, consistent with hemorrhage or necrosis. When contrast is used, the lesions again appear to be heterogeneous as shown in all three cases, nevertheless these signs can also be compatible with benign hemangiomata [1,5,6]. In the third case this led to a delay in diagnosis.…”
Section: Discussionmentioning
confidence: 76%
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