Primary anorectal Hodgkin lymphoma: report of a case and review of the literature

Ambrosio, Maria Raffaella; Rocca, Bruno Jim; Barone, Aurora; Mastrogiulio, Maria Grazia; Costa, Anna Laura; Bellan, Cristiana; Lazzi, Stefano

doi:10.1016/j.humpath.2013.09.015

Cited by 12 publications

(11 citation statements)

References 18 publications

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“…The proportion of HL in children and adolescents in this study is 24.3% higher than that observed in western countries (11%-15%) [ 14 ]. Most HL patients showed lymphadenopathy which coordinates with other published data [ 15 ]. However, the majority of children and adolescents’ lymphomas was NHL.…”

Section: Discussionsupporting

confidence: 90%

Clinicopathological features and EBV infection status of lymphoma in children and adolescents in South China: a retrospective study of 662 cases

et al. 2018

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BackgroundThe clinicopathological features and Epstein-Barr virus (EBV) infection status of lymphoma in children and adolescents in South China is under-researched. South China is a well-known high-incidence area of EBV-associated nasopharyngeal carcinoma.MethodsA cohort of 662 consecutive children and adolescents’ lymphomas was retrospectively analyzed and Epstein-Barr virus encoded RNAs (EBERs) in situ hybridization was performed to detect the EBV infection.ResultsThe majority (501/662, 75.7%) of lymphomas in children and adolescents was Non-Hodgkin lymphoma (NHL). One hundred sixty one cases (24.3%) were Hodgkin lymphoma (HL). Of the NHL, precursor cell lymphoma, mature B-cell lymphoma and peripheral T/NK-cell lymphoma accounted for 32.0%, 41.1% and 26.9% respectively. The five common subtypes were lymphoblastic lymphoma (32.0%), Burkitt lymphoma (BL) (21.0%), anaplastic large-cell lymphoma (ALCL) (14.2%), diffuse large B-cell lymphoma (DLBCL) (13.8%) and extranodal NK/T-cell lymphoma, nasal type (ENKTCL) (6.2%). EBV infection was detected in 58.9% classical Hodgkin lymphomas (CHLs), 21.4% mature B-cell lymphomas and 52.4% peripheral T/NK-cell lymphomas. Moreover, EBV was associated with high grade NHL including ENKTCL (100.0%), BL (30.5%) and DLBCL (17.6%).ConclusionThe high proportion of peripheral T/NK-cell lymphomas in children and adolescents in South China are presented in this study and compared to western countries due to the high percentage of ENKTCL. ENKTCL is firmly associated with EBV infection, while more than half of HL, a portion of BL and DLBCL are related to EBV infection. This study conclusively demonstrates that EBV infection is more prevalent in children and adolescents with lymphomas in South China compared to western countries.Electronic supplementary materialThe online version of this article (10.1186/s13000-018-0693-0) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 90%

Clinicopathological features and EBV infection status of lymphoma in children and adolescents in South China: a retrospective study of 662 cases

et al. 2018

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“…The criteria to assess the primitivity of a LBL establish that diagnosis is correct only if the disease is confined to the organ and no signs of leukemia are present at diagnosis or develop during follow-up [15,16]. Therefore, our cases may be considered as primary T-LBL.…”

Section: Discussionmentioning

confidence: 99%

Unusual presentation of primary T-cell lymphoblastic lymphoma: description of two cases

et al. 2014

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BackgroundT-cell lymphoblastic lymphoma comprises approximately 85-90% of all lymphoblastic lymphomas. It often arises as a mediastinal mass, and with bone marrow involvement. Presentation at other sites without nodal or mediastinal localization is uncommon.Case reportWe describe clinical, histologic, immunohistochemical, and molecular features of two cases of primary T-cell lymphoblastic lymphoma arising respectively in uterine corpus and testis. The tumors were composed by medium to large cells, exhibiting a diffuse pattern of growth but sometimes forming indian files or pseudo-rosettes. The neoplastic cells strongly expressed TdT and T-cell markers in both uterine corpus and testis. However, the testis case also showed aberrant expression of B-cell markers, thus molecular biology was necessary to achieve a final diagnosis. T-cell receptor gene rearrangement analysis identified a T-cell origin.ConclusionsTo the best of our knowledge, only one doubtful previous case of primary uterine T-cell lymphoblastic lymphoma and no previous cases of primary testicular T-cell lymphoblastic lymphoma have been reported. Due to the morphology of neoplastic cells, a challenging differential diagnosis with all the tumors belonging to the so-called small round blue cell tumor category is mandatory. In ambiguous lineage cases, molecular biology may represent an adequate tool to confirm diagnosis.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1559880973128230

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“…The technique was carried out in the BenchMark Ultra (Ventana/ROCHE) platform according to the manufacturer’s instructions, as previously described [20]. …”

Section: Methodsmentioning

confidence: 99%

“…In situ hybridization for detection of the EBV-encoded small RNAs (EBER) was performed using the INFORM EBER Probe (Ventana/ROCHE, Tucson, AZ, US). The technique was carried out in the BenchMark Ultra (Ventana/ROCHE) platform according to the manufacturer’s instructions, as previously described [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

Granulysin, a novel marker for extranodal NK/T cell lymphoma, nasal type

et al. 2018

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Granulysin is a cytolytic protein expressed in cytotoxic T and natural killer (NK) cells. Abnormal serum levels of granulysin in lymphomas with NK and cytotoxic phenotype have been shown to correlate with tumour progression. In this study, we investigated the expression pattern of granulysin in routine sections of normal and reactive lymphoid tissues as well as in a large series of lymphomas. In normal tissues, granulysin labelled a small population of cells that double immunostaining revealed to belong to the pool of cytotoxic T/NK cells. Among lymphoid neoplasms, the highest expression of granulysin (71%) was found in extranodal NK/T cell lymphomas of nasal type (ENKTL). To note is that 29% of ENKTLs, which were negative for one or more of classical cytotoxic markers strongly expressed granulysin. Furthermore, expression of granulysin was observed in rare cases of T cell lymphomas with a cytotoxic phenotype (i.e. ALK-negative anaplastic large cell lymphoma (26%), enteropathy-associated T cell lymphoma (12%) and peripheral T cell lymphoma, NOS (4%)). None of the investigated non-Hodgkin B cell lymphomas, Hodgkin lymphoma and plasma cell myeloma were granulysin positive. The results suggest granulysin as a novel marker for a subset of cytotoxic NK cell derived malignancies and its usefulness is highlighted in those ENKTLs that lack expression of other cytotoxic markers but retain granulysin expression.

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Primary anorectal Hodgkin lymphoma: report of a case and review of the literature

Cited by 12 publications

References 18 publications

Clinicopathological features and EBV infection status of lymphoma in children and adolescents in South China: a retrospective study of 662 cases

Clinicopathological features and EBV infection status of lymphoma in children and adolescents in South China: a retrospective study of 662 cases

Unusual presentation of primary T-cell lymphoblastic lymphoma: description of two cases

Granulysin, a novel marker for extranodal NK/T cell lymphoma, nasal type

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