Primary Auditory Cortex and the Thalamo-Cortico-Thalamic Circuitry I. Anatomy

Budinger, Eike

doi:10.1016/b978-0-12-805408-6.00022-1

Cited by 3 publications

(15 citation statements)

References 417 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Limited data (Gurung and Fritzsch, 2004;Razak et al, 2009) shows the earliest projection that has a prominent expression of Neurod1 to the IC to project to the auditory nucleus (Malone et al, 2021). The central part of the IC is organized in a tonotopic organization that responds to both direct and indirect fibers (Malmierca, 2015;Budinger, 2020).…”

Section: Auditory Nuclei Depend On Atoh1mentioning

confidence: 99%

“…The MGB consists of several subareas, the major parts being the ventral (MGV), medial (MGM), and dorsal (MGD) divisions (Budinger, 2020). Its main ascending input, from the ventral nucleus of the medial geniculate body, provides connections that comprise only a fraction of the inputs to the auditory cortex (A1; ∼18%), where these ascending signals are integrated with feedback connections from ipsilateral (∼70%) and contralateral (∼10%) cortex (Malone et al, 2021).…”

Section: Auditory Nuclei Depend On Atoh1mentioning

confidence: 99%

“…The MGV constitutes the tonotopic lemniscal part of the MGB (Figure 5A). The MGD and MGM are usually assigned to the largely non-tonotopically organized, non-lemniscal position (Malmierca, 2015;Budinger, 2020). MGB and IC receive direct input from the auditory cortex to influence information processing (Budinger, 2020;King, 2020).…”

Section: Auditory Nuclei Depend On Atoh1mentioning

confidence: 99%

“…The MGD and MGM are usually assigned to the largely non-tonotopically organized, non-lemniscal position (Malmierca, 2015;Budinger, 2020). MGB and IC receive direct input from the auditory cortex to influence information processing (Budinger, 2020;King, 2020). In summary, a bilateral relay from the IC is mostly unilateral to the MGB, which expands bilaterally in the auditory cortex.…”

Section: Auditory Nuclei Depend On Atoh1mentioning

confidence: 99%

“…'Receptive fields' (RF) end up a particular stimulus dimension: the choice of acoustic stimulus dimensions to explore are related to the basic perceptual attributes such as spectral pitch (frequency), loudness (intensity), periodicity, or virtual pitch (amplitude modulations, harmonic series), timbre (spectral envelope), and sound location (interaural time, level differences, and spectral shape). In humans, hemispheric asymmetries between the left and suitable auditory cortex form in gross anatomical features and cortical microcircuitry (Budinger, 2020;Rauschecker, 2021).…”

Section: Auditory Integrationmentioning

confidence: 99%

See 4 more Smart Citations

Neurosensory development of the four brainstem-projecting sensory systems and their integration in the telencephalon

Fritzsch

Elliott

Yamoah

2022

Front. Neural Circuits

View full text Add to dashboard Cite

Somatosensory, taste, vestibular, and auditory information is first processed in the brainstem. From the brainstem, the respective information is relayed to specific regions within the cortex, where these inputs are further processed and integrated with other sensory systems to provide a comprehensive sensory experience. We provide the organization, genetics, and various neuronal connections of four sensory systems: trigeminal, taste, vestibular, and auditory systems. The development of trigeminal fibers is comparable to many sensory systems, for they project mostly contralaterally from the brainstem or spinal cord to the telencephalon. Taste bud information is primarily projected ipsilaterally through the thalamus to reach the insula. The vestibular fibers develop bilateral connections that eventually reach multiple areas of the cortex to provide a complex map. The auditory fibers project in a tonotopic contour to the auditory cortex. The spatial and tonotopic organization of trigeminal and auditory neuron projections are distinct from the taste and vestibular systems. The individual sensory projections within the cortex provide multi-sensory integration in the telencephalon that depends on context-dependent tertiary connections to integrate other cortical sensory systems across the four modalities.

show abstract

Section: Auditory Nuclei Depend On Atoh1mentioning

confidence: 99%

Section: Auditory Nuclei Depend On Atoh1mentioning

confidence: 99%

Section: Auditory Nuclei Depend On Atoh1mentioning

confidence: 99%

Section: Auditory Nuclei Depend On Atoh1mentioning

confidence: 99%

Section: Auditory Integrationmentioning

confidence: 99%

See 3 more Smart Citations

Neurosensory development of the four brainstem-projecting sensory systems and their integration in the telencephalon

Fritzsch

Elliott

Yamoah

2022

Front. Neural Circuits

View full text Add to dashboard Cite

show abstract

Selective Interruption of Auditory Interhemispheric Cross Talk Impairs Discrimination Learning of Frequency-Modulated Tone Direction But Not Gap Detection and Discrimination

et al. 2022

View full text Add to dashboard Cite

Functional hemispheric lateralization is a basic principle of brain organization. In the auditory domain, the right auditory cortex (AC) determines the pitch direction of continuous auditory stimuli whereas the left AC discriminates gaps in these stimuli. The involved functional interactions between the two sides, mediated by commissural connections, are poorly understood. Here, we selectively disrupted the interhemispheric cross talk from the left to the right primary AC and vice versa using chromophore-targeted laser-induced apoptosis of the respective projection neurons, which make up 6-17% of all AC neurons in Layers III, V, and VI. Following photolysis, male gerbils were trained in a first experimental set to discriminate between rising and falling frequency-modulated (FM) tone sweeps. The acquisition of the task was significantly delayed in lesioned animals of either lesion direction. However, the final discrimination performance and hit rate was lowest for animals with left-side lesioned commissural neurons, demonstrating that also information from the left AC is relevant for FM direction learning. Photolysis after successful learning did not affect the retrieval of the learned task, indicating that the disruption during learning was not because of a general functional impairment. In a second experimental set, the gerbil's ability to detect and discriminate small silent gaps of varying length within FM sweeps was tested. This ability was also preserved after interhemispheric disruption. Taken together, interhemispheric communication between the left and right AC is important for the acquisition of FM tone direction learning but not for its retrieval and for gap detection and gap duration discrimination.

show abstract

The Development of Speaking and Singing in Infants May Play a Role in Genomics and Dementia in Humans

2023

View full text Add to dashboard Cite

The development of the central auditory system, including the auditory cortex and other areas involved in processing sound, is shaped by genetic and environmental factors, enabling infants to learn how to speak. Before explaining hearing in humans, a short overview of auditory dysfunction is provided. Environmental factors such as exposure to sound and language can impact the development and function of the auditory system sound processing, including discerning in speech perception, singing, and language processing. Infants can hear before birth, and sound exposure sculpts their developing auditory system structure and functions. Exposing infants to singing and speaking can support their auditory and language development. In aging humans, the hippocampus and auditory nuclear centers are affected by neurodegenerative diseases such as Alzheimer’s, resulting in memory and auditory processing difficulties. As the disease progresses, overt auditory nuclear center damage occurs, leading to problems in processing auditory information. In conclusion, combined memory and auditory processing difficulties significantly impact people’s ability to communicate and engage with their societal essence.

show abstract

Primary Auditory Cortex and the Thalamo-Cortico-Thalamic Circuitry I. Anatomy

Cited by 3 publications

References 417 publications

Neurosensory development of the four brainstem-projecting sensory systems and their integration in the telencephalon

Neurosensory development of the four brainstem-projecting sensory systems and their integration in the telencephalon

Selective Interruption of Auditory Interhemispheric Cross Talk Impairs Discrimination Learning of Frequency-Modulated Tone Direction But Not Gap Detection and Discrimination

The Development of Speaking and Singing in Infants May Play a Role in Genomics and Dementia in Humans

Contact Info

Product

Resources

About