Primary autoimmune myelofibrosis: Twenty years in making

Abstract

We present a case of long-term follow up of primary autoimmune myelofibrosis (AIMF) that started in childhood. A 3-year-old female child developed fatigue and epistaxis for 8 months. There was no history of any other bleeding manifestation, jaundice, pain abdomen, B symptoms or swellings. She had received five packed red blood cells and four random donor platelets transfusions over the 8-month period.There was no history of consanguinity in the family. On examination, pallor was present and petechiae were noted over the legs. There was no lymphadenopathy, icterus, clubbing, edema, dysmorphic features or organomegaly.