Primary, Bilateral and Diffuse Renal Non-Hodgkin’s Lymphoma in a Young Woman Suffering from Turner Syndrome

Abstract

Primary renal lymphoma (PRL) is a rare form of non-Hodgkin’s lymphoma (NHL) restricted to and primarily involving one or both kidneys, with no lymph node extension. It accounts for <1% of extranodal lymphomas, and descriptions in the literature are limited. Here, we describe an unprecedented case of bilateral PRL in a 44-year-old woman with Turner syndrome and discuss both diagnostic and therapeutic issues in the light of the available literature in the field. A personalized approach to this rare disease is necessary.

Primary lymphoma of the kidney

“…The clinical signs of renal involvement were proteinuria, renal failure, and enlargement of the kidney in radiological evaluation. 7,16 In the current study, renal function impairment or failure was seen in some patients. Acute kidney injury is a well-known clinical feature of bilateral PRL.…”

“…The clinical signs of renal involvement were proteinuria, renal failure, and enlargement of the kidney in radiological evaluation. 7 , 16 …”

“… 35 , 36 It has also been reported in association with other diseases such as chronic hepatitis C infection and Turner syndrome. 16 , 37 Synchronous PRL and RCC have been described in the literature. 38 - 40 …”

“…The Ki-67 range was 50-85%. Two ) 16.7%( of the DLBCLs were further subclassified to be GCB subtype, and 8 )66.7%( were subclassified into the non-GCB subtype. In the other 2 cases, no material was available to carry out immunohistochemistry study required for subtyping.…”

“…35,36 It has also been reported in association with other diseases such as chronic hepatitis C infection and Turner syndrome. 16,37 Synchronous PRL and RCC have been described in the literature. [38][39][40] According to the data obtained from SEER, Taneja et al 2 showed that the median age is above 70 years.…”