Primary bone lymphoma involving bilateral tibia

Giardino, Angela; Shinagare, Atul B.; Shinagare, Shweta; Dewar, Rajan; Weckstein, Doug; Mauch, Peter; Ramaiya, Nikhil H.; Freedman, Arnold S.

doi:10.1002/ajh.23245

Cited by 7 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors stress the point that the proximal tibia was the predominant site in the majority of the patients. In some cases tibial involvement could be bilateral [12]. Inyoung individuals large B-cell lymphoma of the tibia may imitate other malignant tumors [13].…”

Section: Discussionmentioning

confidence: 99%

Primary Large B Cell Lymphoma in the Tibia of an Old Individual Relapsing at an Uncommon Location

Djaldetti¹

2019

Arch Hematol Blood Dis

View full text Add to dashboard Cite

Involvement of the bones is a rare presentation of diffuse large B cell non-Hodgkin's lymphoma and afects mostly jounger individuals. The tibia, as the initial site of the disease is a rather ucomon target, particularly when it emerges at older age. We present a 94 old individual with large B-cell lymphoma stage IV E that involved the right upper tibia treated by CHOP-R and that relapsed one year later at the right testicle. The rarity of bone invivment, the old age and the unusual site of relaps are disussed.

show abstract

Section: Discussionmentioning

confidence: 99%

Primary Large B Cell Lymphoma in the Tibia of an Old Individual Relapsing at an Uncommon Location

Djaldetti¹

2019

Arch Hematol Blood Dis

View full text Add to dashboard Cite

show abstract

“…Differential diagnosis should be considered, such as Ewing sarcoma, osteosarcoma, chronic osteomyelitis, [11] and lymphoblastic lymphoma/leukemia. Ewing sarcoma often occurs in the diaphysis of long bones in people younger than 20 years and in flat bones in people older than 20 years.…”

Section: Discussionmentioning

confidence: 99%

Primary bone lymphoma of radius and tibia

Huan

Qi²,

Zhang³

et al. 2017

Medicine

View full text Add to dashboard Cite

Rationale:Primary bone lymphoma (PBL) is a rare malignant entity. There is a better survival of PBL than any other malignant bone tumors and extranodal lymphomas.Patient concerns:We report a rare case of PBL involving radius and tibia. The patient was a 14-year-old girl with left forearm pain and swelling after trauma. Six months later after the last chemotherapy and radiotherapy, pain and swelling of left knee was presented.Diagnoses:Radiological imaging revealed a lytic destruction, periosteal reaction, and pathological fracture of radius and tibia with soft tissue mass. Surgical biopsy was performed, and the result of histopathological diagnosis was diffused large B-cell lymphoma (stage IV, group A).Intervention:Chemotherapy combined with radiotherapy was applied before curation.Lessons:Due to its uncommon presentation, PBL should be taken into consideration if differential diagnosis from other bone tumors is necessary in clinic.

show abstract

“…The bilateral presentation in the proximal tibias with sparing of other sites has also been described by others. For example, two recent case reports both show striking images of bilateral proximal tibial lymphoma, although both in older males 25 26 .…”

Section: Discussionmentioning

confidence: 99%

A highly curable lymphoma occurs preferentially in the proximal tibia of young patients

et al. 2014

View full text Add to dashboard Cite

The presentation of two 19 year old males with stage I non-Hodgkin lymphoma in the proximal tibia prompted an extensive review of institutional and national databases to assess if there is any statistical evidence that these reflected a previously overlooked syndromic pattern of presentation. The institutional records of a single institution were reviewed for presentation of non-Hodgkin lymphoma in bone. The records of two additional institutions were reviewed for all reports of non-Hodgkin lymphoma in the tibia. Analysis was performed on data from SEER (Surveillance, Epidemiology, and End Results) dichotomized to bone presentation in the lower extremity versus other bones. Institutional databases included 20 patients with tibial presentation of lymphoma with a median age of 22.5 years (versus 42 for all bone lymphomas; p<0.001). 18/20 were diffuse large B cell lymphoma, and all patients ≤ 40 achieved remission and apparent cure. Distinctive and unusual features were a tendency for bilateral involvement of the tibia and sclerotic changes on X-ray. SEER data included 808 cases of bone lymphoma; the fraction of cases presenting in the lower extremity vs other bone sites is higher at ages ≤ 40 years (38% vs 19%; p < 0.0001). Presentation in the lower extremity, as compared to other bone sites, confers 97% overall survival in patients ≤ 40 (vs. 82%; p = 0.01). This survival effect was independent of stage. In contrast, no significant difference in overall survival was identified for lower extremity versus non-lower extremity site for age > 40. These data show a previously undescribed syndromic pattern of disease presentation: bone lymphoma in young patients is likely to present in the lower extremity, specifically the proximal tibia, has atypical sclerotic features on x-ray, is often bilateral, and has an excellent prognosis compared to bone lymphomas at other sites matched for stage and age.

show abstract

Primary bone lymphoma involving bilateral tibia

Cited by 7 publications

References 7 publications

Primary Large B Cell Lymphoma in the Tibia of an Old Individual Relapsing at an Uncommon Location

Primary Large B Cell Lymphoma in the Tibia of an Old Individual Relapsing at an Uncommon Location

Primary bone lymphoma of radius and tibia

A highly curable lymphoma occurs preferentially in the proximal tibia of young patients

Contact Info

Product

Resources

About