Primary Bone Lymphoma Mimicking as Osteomyelitis: An Unusual Presentation

Badam, Tarun Kumar; Devadoss, Sathish; Balaji, M. Vijay; Devadoss, A. Victor; Pn, Rajasekharan

doi:10.4172/2472-016x.1000111

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…There are a number of case reports in the literature where the PBL mimicked subacute and chronic osteomyelitis and was treated as osteomyelitis [ 7 - 10 ]. The rarity of the disease and the misleading histopathological and imaging features placed PBL last on the list of our differential diagnoses for a 32-year-old male patient with insidious onset pain, intermittent fever, and diffuse and tender swelling with normal X-ray and non-specific MRI features.…”

Section: Discussionmentioning

confidence: 99%

Primary Bone Lymphoma of the Shaft of the Tibia, Mimicking Subacute Osteomyelitis

Jayaprakasan¹,

Warrier²

2023

Cureus

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We present the case of a 32-year-old healthy male who presented with a three-month history of insidious onset pain and swelling over the right tibia. Initial radiographs and imaging pointed to a diagnosis of subacute osteomyelitis, as there was no cortical destruction, periosteal reaction, or soft tissue involvement. The patient underwent surgery for osteomyelitis. However, the histopathology and immunohistochemistry (IHC) findings pointed to a possible B-cell lymphoma diagnosis. The patient was referred to a tertiary-level oncology centre, where a repeat biopsy and positron emission tomography (PET) scan confirmed a diagnosis of primary bone lymphoma (PBL). Treatment was initiated immediately in the form of a combination of chemotherapy and radiotherapy, and the progress was followed up with further scans at four-month intervals. The patient achieved remission nine months after the initiation of treatment.

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Section: Discussionmentioning

confidence: 99%

Primary Bone Lymphoma of the Shaft of the Tibia, Mimicking Subacute Osteomyelitis

Jayaprakasan¹,

Warrier²

2023

Cureus

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“…In this article, we report a 34-year-old man who presented progressive hip pain and osteolytic bone lesions. He was later diagnosed with primary diffuse large B-cell bone lymphoma, and previous studies had also suggested that osteomyelitis unusually mimics PB-DLBCL [5][6][7] Several rationales led us to believe that the previous workup session was insufficient, and another approach is needed to be taken. Hence, we decided to perform an open biopsy.…”

Section: Discussionmentioning

confidence: 99%

Primary diffuse large B‐cell lymphoma of the bone mimicking osteomyelitis

mofidi

Esfandbod

Pendar

et al. 2021

Clinical Case Reports

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In this article, we report a 34-year-old man who presented with progressive hip pain and osteolytic bone lesions.Primary workups included core needle biopsies manifested as osteomyelitis; however, as no sign of remission was observed, an open biopsy was considered which revealed primary bone lymphoma.Primary bone diffuse large B-cell lymphoma (PB-DLBCL) is a destructive primary extranodal lymphoma that accounts for 55.7% of all primary bone lymphomas. 1 Patients are clinically presented with bone pain that is not relieved by rest, soft tissue swelling, palpable mass, pathologic fracture, joint contracture, cord compression, and systemic symptoms such as fever, unintentional weight loss, and night sweats. 2 The common primary site of bone involvement is the axial skeleton rather than the appendicular skeleton (63 versus 37 percent). 3 The diagnosis of (PB-DLBCL) is based on both imaging and histopathologic findings. Tissue samples can be taken either percutaneously or via open biopsy. Few primary bone lymphoma cases have been reported in the literature. These cases are usually misdiagnosed, particularly with osteomyelitis. The symptoms often persist for many months before the patient seeks appropriate medical care. 4 Herein, we describe a 34-year-old young man with persistent bone pain whose core needle biopsies were consistent with osteomyelitis; however, his open biopsy revealed PB-DLBCL to be the underlying cause. | CASE PRESENTATIONA 34-year-old man with no significant past medical or surgical history complaining of dull low back pain and non-traumatic progressive right hip pain, which he had

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