Primary bone mantle cell lymphomas with multiple vertebral compression fractures: A case report

Abstract

Abstract. Mantle cell lymphoma (MCL) is a mature B-cell non-Hodgkin lymphoma. Patients with MCL generally present with extensive lymphadenopathy and extranodal involvement. To the best of our knowledge, no cases of primary bone MCL with multiple vertebral compression fractures have been reported in the literature thus far. The current study reports the case of a 75-year-old Chinese male patient presenting with lower back pain for 1 year. B symptoms were not observed in the patient's medical history. X-ray revealed osteoporosis, and mixed osteolytic and osteosclerotic lesions in the T10 and L1 vertebrae with decreased height. Computed tomography of the spine showed multiple vertebral compression fractures, particularly at T10 and L1. Furthermore, magnetic resonance imaging demonstrated a diffuse homogeneous abnormal signal with multiple vertebral compression fractures. The patient underwent vertebral biopsy and percutaneous balloon kyphoplasty. Histopathological examination of the biopsy revealed abnormal, diffuse, atypical, small-sized, slightly irregular lymphocytes with condensed chromatin. Immunohistochemical staining showed CD5 + , CD20+ and cyclin D1 + . Thus, the patient was diagnosed with primary bone MCLs and chemotherapy was administered. During the 2-month follow-up, the patient remained in a good clinical condition. The present study reports a rare case of primary osseous MCL and a review of the literature.

Bulky primary tibia mantle cell lymphoma achieved complete remission with CHOP and DHAP plus rituximab: A case report

“…Although skeletal involvement is not uncommon in other types of non-Hodgkin lymphoma, the available literature on this in primary bone MCL is limited (7). To the best of our knowledge, only one case of primary spinal MCL has been previously reported (2). In the present case report, the imaging data provided evidence that MCL may have a clear bone origin without involvement of lymph nodes.…”

“…Although bone marrow, and the circulatory and the gastrointestinal systems are often involved, primary bone MCL is rare. To the best of our knowledge, only one case of primary spinal MCL has been reported in the literature to date (2). The present study discussed a case of bulky primary tibia MCL, for which complete remission was achieved with R (rituximab)-CHOP (rituximab 600 mg on day 1, cyclophosphamide 1.2 g on day 2, vindesine 4 mg on day 2, epirubicin 96 mg on day 2, prednisone 50 mg every 12 h on days 2-6) and R-DHAP (rituximab 600 mg on day 1, cisplatin 168 mg on day 2, cytarabine 3.3 g/q12h on day 3, dexamethasone 40 mg on days 2-5).…”

Extremely Rare Primary Spinal Epidural Indolent Mantle Cell Lymphoma: A Case Report With Literature Review

“…These reports suggest that all the cases had an aggressive course of the disease. However, a case with bony MCL of thoracic (T10) and lumbar (L1) vertebrae was treated by kyphoplasty and biopsy, followed by eight cycles of combination chemotherapy, and remained in good clinical condition at one-year follow-up except complaining of slight back pain [ 18 ].…”

Imaging features of primary spinal osseous tumors and their value in clinical diagnosis

“…It is characterized by various types, low differences in imaging features and difficult diagnosis. As the nerves and capillaries are densely distributed around the spine, removal of the tumor with minimal wound can be reached only after the occurrence site and the scope of the tumor are mastered well (3). Therefore, in order to reduce misdiagnosis and postoperative recurrence rates, a total of 69 patients with primary spinal osseous tumors were analyzed to further explore the imaging features and provide guidance for clinical diagnosis and treatment.…”