Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Aebi, Stefan; Davidson, T.; Gruber, Günther; Cardoso, Fátima

doi:10.1093/annonc/mdr371

Cited by 240 publications

(176 citation statements)

References 88 publications

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“…IHC analysis enables to identify those cell receptors using antibodies that specifically bind with antigens present in the tissue samples and this antibody-antigen binding can be detected usually by chemical or, enzymatic staining. 38,39 However, IHC analysis facility is very poor in Bangladesh thus presenting a poor diagnosis condition for TNBC in Bangladesh leading to patients having inappropriate treatment regimen in most cases.…”

Section: Tnbc Diagnosismentioning

confidence: 99%

Study on epidemiology, risk factors and clinical characteristics of triple negative breast cancer in Bangladesh

Zohora

Rabbi

2018

Int J Res Med Sci

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Breast cancer is the second most common type of cancer in Bangladesh. Although significant improvement has been made in breast cancer treatment and management, Triple Negative Breast Cancer (TNBC) is still the least known breast cancer subtype in this country. TNBC is well known for its aggressive nature and limited therapeutic options when compared to other breast cancer subtypes. Several population-based studies indicated high prevalence of TNBC in African women in addition to few recent studies indicating a growing number of TNBC patients among Asian population. However, there is a lack of evidence on TNBC patients in Bangladesh due to limited knowledge and awareness. In this paper we review the epidemiology, general risk factors and clinical characteristics of TNBC to find out the correlation between TNBC and other conventional breast cancer subtypes in Bangladesh. Some diagnostic and therapeutic approaches as well as future novel solutions for TNBC are also discussed to understand the pathologic process and treatment strategies of TNBC. Literature review reveals that, there is a lack of TNBC studies in Bangladesh. Therefore, more investigations should be carried out to address the degree of vulnerability of TNBC in breast cancer patients of Bangladesh.

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Section: Tnbc Diagnosismentioning

confidence: 99%

Study on epidemiology, risk factors and clinical characteristics of triple negative breast cancer in Bangladesh

Zohora

Rabbi

2018

Int J Res Med Sci

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“…According to the AJCC/UICC TNM system's latest edition, the College of American Pathologists (2009) and the ESMO guidelines, only the largest tumor focus should be selected for classification, grading, and staging (35,36,42,43). Clinical decisions in systemic adjuvant therapy for breast cancer are presently based on morphological criteria of the largest tumor focus, ignoring those of the smaller simultaneous cancers even though the heterogeneity of individual foci in multiple carcinomas has not been widely studied (44)(45)(46).…”

Section: Morphological Profilementioning

confidence: 99%

“…International therapeutic guides recommend adjuvant endocrine therapy (Tamoxifen) in patients with breast carcinoma in which the tumor expresses estrogen receptors (ERs) and/or progesterone receptors (PRs), as well as anti-human epidermal growth factor receptor 2 (HER2) therapy (Trastuzumab) in HER2-positive cases (43,44,45,48). An increased proliferative index (Ki-67), a high histological grade, and ER/PR negativity are factors that indicate the use of chemotherapy (43,46).…”

Section: Molecular Profilementioning

confidence: 99%

Review on Practical Approach in Multiple Breast Carcinomas: Does Each Focus Matter?

Boros¹,

Georgescu²,

Podoleanu³

et al. 2017

chr

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RezumatCarcinomul mamar reprezintă cea mai frecventă tumoră malignă ce se dezvoltă la sexul feminin. De obicei, este o tumoră unică dar, uneori, poate fi multiplă. Datele din literatură cu privire la incidenţa, definiţia, profilul morfologic şi molecular, tratamentul şi prognosticul carcinoamelor mamare multiple sunt contradictorii, de aceea, acest articol prezintă o abordare practică pentru cei implicaţi în diagnosticul şi tratamentul unei astfel de leziuni care, poate prezenta heterogeneitate morfologică şi moleculară, acest lucru având un impact asupra managementului şi prognosticului. De aceea, este esenţial ca focarele tumorale multiple să se raporteze separat şi să fie luate în considerare în momentul unei decizii terapeutice.Cuvinte cheie: focare tumorale multiple, carcinom mamar Abstract Breast carcinoma is the most frequent form of cancer encountered in women worldwide. In the routine practice, most of breast carcinomas are diagnosed as unifocal, however, a variable proportion is represented by multiple tumor foci. Since data regarding the incidence, definition, morphological and molecular profile, treatment and

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“…As a result, there has been much debate regarding the timing of mastectomy in patients requiring radiotherapy. Most guidelines that address the timing of adjuvant radiotherapy recommend that breast reconstruction be delayed, or at least, discussed in a multidisciplinary setting (22,24,27 (63,64). A prospective study comparing timing of radiotherapy on permanent implants versus on tissue expanders (all two-stage immediate with subpectoral temporary expanders and permanent implants) found that the rate of failure (ie, removal of the implant, leaving the chest wall flat or change to a flap-based technique) was significantly higher when radiotherapy was delivered at the tissue expander stage rather than at the permanent implant stage (40% versus 6.4%; P<0.0001).…”

Section: What Is the Appropriate Timing Of Breast Reconstruction?mentioning

confidence: 99%

Breast reconstruction following prophylactic or therapeutic mastectomy for breast cancer: Recommendations from an evidence-based provincial guideline

Budgell¹,

Quan²,

Mehling³

et al. 2014

CAN J PLAST SURG

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Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Cited by 240 publications

References 88 publications

Study on epidemiology, risk factors and clinical characteristics of triple negative breast cancer in Bangladesh

Study on epidemiology, risk factors and clinical characteristics of triple negative breast cancer in Bangladesh

Review on Practical Approach in Multiple Breast Carcinomas: Does Each Focus Matter?

Breast reconstruction following prophylactic or therapeutic mastectomy for breast cancer: Recommendations from an evidence-based provincial guideline

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