Primary Breast Cancer in Aberrant Breast Tissue in the Axilla

Yerra, L; Karnad, Anand B.; Votaw, May L.

doi:10.1097/00007611-199706000-00018

Cited by 53 publications

(52 citation statements)

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“…Primary breast carcinoma arising in accessory breast tissue of the axilla is the most common clinical presentation, comprising 60-70% of all ectopic breast tumours (16,17). The most common pathology of accessary breast tissue carcinoma, as with normal breast carcinoma, is invasive ductal carcinoma (18). The most common physical manifestation of this carcinoma is a palpable mass.…”

Section: Discussionmentioning

confidence: 99%

“…Generally, a diagnosis of accessory breast cancer requires a pathological demonstration of cancerous tissue adjacent to normal breast ducts or lobules that are not connected to the proper mammary gland. It is also necessary to exclude the possibility of a metastatic lesion from another primary cancer (18). An accurate diagnosis of axillary accessory breast carcinoma is important, as it can provide precise staging information for patients with concurrent ipsilateral breast cancer (7).…”

Section: Discussionmentioning

confidence: 99%

“…Evans et al (2) reported that 71% of ectopic breast cancers were located in the axilla. Marshall et al (3) reported that 58% occurred in the axilla, 18.5% in the parasternal, 8.6% in the subclavicular, 8.6% in the submammary, and 4% in the vulvar; 94.7% of patients were women, and only 5.3% were men. Breast tissues develop from the ectodermal ridges, also known as the milk lines, on the ventral surface of the body, which extend from the axillae to the inguinal regions and end on the medial aspect of the thighs on each side of the body (4).…”

Section: Introductionmentioning

confidence: 99%

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Diagnosis and treatment of accessory breast cancer in 11 patients

Zhang

et al. 2015

Oncology Letters

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Abstract. The present study aimed to investigate the clinical characteristics, diagnosis and treatment of accessory breast cancer, and contribute valuable information regarding this rare tumour to the current literature, ultimately facilitating the development of improved treatment strategies. The present study reported the cases of 11 patients with accessory breast cancer. The patients with accessory breast cancer were admitted between January 2002 and June 2014, and the patient records were retrospectively analysed. All patients presented with a tumour that was localised in the axilla. Out of these patients, there were 8 patients with invasive ductal carcinoma and 3 patients with invasive lobular carcinoma. The follow-up periods for patients ranged between 4 and 54 months. Out of the 5 patients that experienced neoplasm metastases, 4 patients succumbed to the disease. In total, 6 patients remain alive with no evidence of disease. Accessory breast cancer is a progressive tumour, and long-term follow-up is required. A comprehensive treatment strategy may be an effective treatment option for patients; however, the optimal time at which to commence chemotherapy and the role of combined radiotherapy and endocrine therapy require additional investigation. IntroductionPrimary carcinomas of ectopic breast tissue have been reported in only a small number of cases and the axilla was the most frequent site of the primary tumor (1). Evans et al (2) reported that 71% of ectopic breast cancers were located in the axilla. Marshall et al (3) reported that 58% occurred in the axilla, 18.5% in the parasternal, 8.6% in the subclavicular, 8.6% in the submammary, and 4% in the vulvar; 94.7% of patients were women, and only 5.3% were men. Breast tissues develop from the ectodermal ridges, also known as the milk lines, on the ventral surface of the body, which extend from the axillae to the inguinal regions and end on the medial aspect of the thighs on each side of the body (4). Embryologically, ectopic breast tissue develops as a result of failed resolution of the mammary ridge, an ectodermal thickening that extends from the axilla to the groin (5). Ectopic breast tissue may appear at any site along the milk line, but it occurs most commonly in the axill; less commonly, it may appear in locations outside of the mammary ridge, including the face, middle back, buttock, posterior neck, chest, vulva, hip, posterior, flank and/or lateral thigh, shoulder and upper extremities (4,6).The diagnostic procedures and therapeutic management of accessory breast carcinoma are not definitively established. The present study aimed to perform an analysis of a series of patients with accessory breast cancer that were treated exclusively with combination chemotherapy and radiotherapy, as well as to review the medical literature with regard to the clinical features, treatment methods and prognosis of this disease. The present study reports 11 such cases, with the goal of contributing valuable information about this unusual tumour to the current literat...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diagnosis and treatment of accessory breast cancer in 11 patients

Zhang

et al. 2015

Oncology Letters

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“…Accessory breast carcinoma in males is extremely rare, with the most common clinical manifestation being accessory breast carcinoma of the axilla (12,15). The most frequent histological type of this lesion is invasive ductal carcinoma (worldwide incidence, 72%) (16,17). In the majority of studies, treatment regimens for accessory breast carcinoma follow the guidelines for breast cancer treatment (9,10,11).…”

Section: Current Case -----------------------------------------------mentioning

confidence: 99%

Male accessory breast cancer successfully treated with endocrine therapy: A case report

Shi

et al. 2015

Oncology Letters

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Abstract. Male accessory breast cancer is an extremely rare tumor. Several risk factors have been identified, including genetic and hormonal abnormalities. Accessory breast carcinoma usually occurs under the axilla or in the inguinal region. Clinical diagnosis is frequently delayed due to the general lack of awareness among physicians and patients. In the present study, the case of a 63-year-old male patient who was diagnosed with accessory breast cancer at a local advanced stage was reported. However, the patient was successfully treated with endocrine therapy.

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“…The incidence of ectopic accessory breast is uncertain, but it is generally accepted to be found in 1-2% of humans [12,13]. EBT is subject to all of the physiological and pathological changes of the normal breast, including carcinoma [14], although carcinoma of aberrant breast tissue is rare [15,16].…”

Section: Introductionmentioning

confidence: 99%

Carcinoma Originating from Aberrant Breast Tissue: Case Report and Review of the Literature

Khanouss¹

2014

J Integr Oncol

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Primary Breast Cancer in Aberrant Breast Tissue in the Axilla

Cited by 53 publications

References 0 publications

Diagnosis and treatment of accessory breast cancer in 11 patients

Diagnosis and treatment of accessory breast cancer in 11 patients

Male accessory breast cancer successfully treated with endocrine therapy: A case report

Carcinoma Originating from Aberrant Breast Tissue: Case Report and Review of the Literature

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