Primary breast diffuse large B cell lymphoma

Abstract

Primary breast lymphoma (PBL) is an uncommon type of breast malignancy. Its clinical presentation and radiographic findings are non-specific and overlap with breast carcinoma. The treatment of PBL differs significantly from breast carcinomas. Here we present a middle-aged woman who presented with an enlarging palpable right breast mass. Mammogram showed breast imaging-reporting and data system 4 findings. Breast mass biopsy pathology confirmed diffuse large B cell lymphoma. Although uncommon, clinicians should be cognisant of the possibility of PBL when patients present with a breast mass. Accurate diagnosis is essential to avoid unnecessary mastectomies.

Bilateral primary breast Burkitt’s lymphoma in pregnancy

“…The average age of PBL diagnosis is in the seventh decade of life, with clinical presentation and imaging findings similar to breast carcinomas 7. Most PBLs are diffuse large B-cell lymphoma (DLBCL) or MALT lymphoma 8–10…”

A rare case of primary breast lymphoma presenting as calcifications on screening mammography

“…EMZL represents approximately 7-8% of all non-Hodgkin lymphomas, with the most common site involving the stomach [1] . Primary involvement of the breast, known as primary breast lymphoma (PBL), is a very rare manifestation of lymphoma representing less than 1% of all breast cancers [ 2 , 3 ]. While characteristic imaging features of primary breast lymphoma are non-specific, the literature describes associated calcifications as extremely rare [4] , [5] , [6] .…”

Linfoma no Hodgkin de células B primario de mama. Reporte de caso y revisión de la literatura

“…Para poder integrar el diagnóstico es necesaria la toma de biopsia, la cual puede ser escisional o por aguja de corte, esta última se prefiere por su naturaleza menos invasiva. No se recomienda la aspiración con aguja fina, ya que con esta no se pueden visualizar datos histopatológicos imprescindibles para la correcta subclasificación de los linfomas (6). Se debe complementar su estudio por medio de inmunohistoquímica con CD15 (antígeno de diferenciación), CD30, CD3, CD45, CD20, CD79a, BCL6 (proteína 6 del linfoma de células B), PAX-5 (paired box) (1).…”

“…Los LPM suelen ser no Hodgkin de tipo células B, siendo más comunes que los de células T, que alcanzan un 7 % 6 . El subtipo más predominante, que representa a la mitad de los LPM, es el difuso de células B grandes (LDCBG) 7 .…”

“…Suele presentarse en mujeres entre la quinta y sexta década de la vida. La glándula mamaria derecha se ha visto mayormente implicada, sin embargo, se ha reportado 10 % de bilateralidad, siendo este un factor de mal pronóstico 6 , 7 . Los síntomas B, que usualmente suelen asociarse con los linfomas, como pérdida de peso, fiebre y sudoraciones nocturnas, no suelen ser tan frecuentes en los LPM 6 .…”