Primary Burkittʼs Lymphoma of the Appendix Presenting as Acute Appendicitis

Jaganmohan, Sathya; Chauvin, Ryan; Burton, Gary V.

doi:10.14309/00000434-200609001-00310

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“…We found less than 20 cases of acute appendicitis in association with lymphomatous infiltration in the English literature. A majority of cases represent Burkitt lymphoma, [ 3 , 6 , 8 , 11 , 15 ] with the remainder of cases representing large cell lymphoma [ 5 , 9 , 12 ] or without classification [ 2 , 10 , 13 , 14 ]. To the best of our knowledge, this is the first case report of appendicitis in an appendix involved by mantle cell lymphoma.…”

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confidence: 99%

Acute Appendicitis in a Man Undergoing Therapy for Mantle Cell Lymphoma

Linden

Gopal

Edlefsen

2012

Case Reports in Hematology

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A 71-year-old man was diagnosed with an aggressive mantle cell lymphoma and was started on six cycles of R-CHOP chemotherapy. Approximately two weeks after starting his first cycle of chemotherapy, he complained of severe right lower quadrant abdominal pain, and an abdominal CT scan demonstrated an enlarged appendix with evidence of contained perforation. The man underwent open appendectomy for acute appendicitis and recovered. The appendectomy specimen was submitted for routine pathological analysis. There was histologic evidence of perforation in association with an inflammatory infiltrate with fibrin adhered to the serosal surface; scattered small lymphoid aggregates were present on the mucosal surface. Although the lymphoid aggregates in the submucosa and lamina propria were rather unremarkable by routine histologic examination, immunohistochemistry revealed the lymphocytes to be predominantly Cyclin D1-overexpressing B cells. To our knowledge, this is the first reported case of acute appendicitis in association with appendiceal involvement by mantle cell lymphoma.

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