Primary cancer of the fallopian tube

Jereczek, B.; Jassem, Jacek; Kobierska, A

doi:10.3109/00016349609047102

Cited by 17 publications

(15 citation statements)

References 28 publications

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“…Well-differentiated tumours were observed in 8%, while 32% had grade 2 and 58% grade 3 tumours, which is in concordance with earlier studies [4] . The distribution of histological subgroups is also comparable with that in earlier studies [29,30] , with 80% serous adenocarcinomas.…”

Section: Discussionsupporting

confidence: 92%

“…The mean age of 61 years of the patients in the present series is similar, while the stage distribution was somewhat different from that reported in other studies [1,3,9] ; only 10% of our patients had stage I disease as compared to 20-42% in earlier studies [3,4,26] . Well-differentiated tumours were observed in 8%, while 32% had grade 2 and 58% grade 3 tumours, which is in concordance with earlier studies [4] .…”

Section: Discussioncontrasting

confidence: 87%

“…Overall 5-year survival was 38% when serum hCG ␤ was below 3.5 pmol/l, while it was 18% when the level was higher the cases are detected at an advanced stage. Despite advances in therapy, the prognosis is poor, the overall 5-year survival rate being 33-57% [3][4][5][6] . The size of the residual tumour, clinical stage, histological grade and age of the patient have been shown to affect prognosis [3,[7][8][9] .…”

Section: Odsmentioning

confidence: 99%

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Preoperative Serum hCGβ as a Prognostic Marker in Primary Fallopian Tube Carcinoma

Riska¹,

Alfthan²,

Finne³

et al. 2006

Tumor Biol

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Objectives: It was the aim of this study to evaluate the prognostic value of the pretreatment serum concentrations of the β-subunit of human chorionic gonadotropin (hCGβ), CA 125 and tumour-associated trypsin inhibitor (TATI) in primary fallopian tube carcinoma (PFTC). Methods: The pretreatment serum concentrations of hCGβ, CA 125 and TATI were analyzed in serum samples from 60 women with a mean age of 61 years, treated for PFTC between 1985 and 2000. Of the 91 patients treated during this period, 31 were excluded because no serum sample was available. The patients were followed-up for recurrence and survival until February 14, 2003. The prognostic value of the serum markers were compared with those of stage, grade and histological type. Results: The median survival time was 27 months and the overall 5-year survival rate 33%. Stage and size of the residual tumour (<1 vs. ≧1 cm) predicted both overall and disease-free survival (p < 0.050). Histology (serous vs. others) (p = 0.023) also influenced overall survival. Overall 5-year survival was 38% when serum hCGβ was below 3.5 pmol/l, while it was 18% when the level was higher (p = 0.052). The corresponding disease-free 5-year survival was 38 and 20%, respectively (p = 0.014). Patients with CA 125 values above 1,017 kU/l had an overall 5-year survival of 39% as compared with 14% for those with lower values (p = 0.009), while the disease-free survival was 37 and 23%, respectively (p = 0.096). Serum TATI was not a prognostic marker. Serum concentrations of hCGβ and CA 125 correlated significantly with stage (p = 0.049 and p = 0.050, respectively). In multivariate Cox proportional hazards regression analysis, only hCGβ, stage and histology emerged as independent prognostic factors. Conclusions: Clearly elevated serum concentrations of hCGβ and CA 125 predict survival in fallopian tube carcinoma, but in multivariate analyses, only hCGβ is a prognostic factor independent of stage and histology.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 87%

Section: Odsmentioning

confidence: 99%

See 1 more Smart Citation

Preoperative Serum hCGβ as a Prognostic Marker in Primary Fallopian Tube Carcinoma

Riska¹,

Alfthan²,

Finne³

et al. 2006

Tumor Biol

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“…Patients with no detectable residual tumor had a 60% 5-year survival rate, but no patient with residual disease was alive at 5 years. This is in accordance with previous reports and stresses the need for radical surgery with maximum debulking (13)(14)(15)(16) . However, whether the poor outcome in patients who had residual tumor left after cytoreductive surgery is due to incomplete surgery or to tumor biology cannot be answered by this study.…”

Section: Discussionsupporting

confidence: 93%

Primary fallopian tube carcinoma: the Queensland experience

Obermair,

Taylor,

Janda

et al. 2001

International Journal of Gynecological Cancer

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The pupose of this study was to review the experience with fallopian tube carcinoma in Queensland and to compare it with previously published data. Thirty-six patients with primary fallopian tube carcinoma treated at the Queensland Gynaecological Cancer Center from 1988 to 1999 were reviewed in a retrospective clinicopathologic study. All patients had primary surgery and 31/36 received chemotherapy postoperatively. Abnormal vaginal bleeding (15/36) and abdominal pain (14/36) were the most common presenting symptoms at the time of diagnosis. Median follow-up was 70.3 months and the median overall survival was 68.1 months. Surgical stage I disease (P= 0.02) and the absence of residual tumor after operation (P= 0.03) were the only factors associated with improved survival. Twenty of the 36 patients (55%) presented with stage I disease and survival was 62.7% at 5 years. No patient with postoperative residual tumor survived.The majority of the patients with fallopian tube carcinoma present with stage I disease at diagnosis, but their survival probability is low compared with that of other early stage gynecological malignancies. If primary surgical debulking cannot achieve macroscopic tumor clearence, the chance of survival is extremely low.

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“…Due to the low prevalence of the disease and heterogeneous postoperative regimens, it is difficult to establish therapeutic guidelines. While some authors favor postoperative chemotherapy like in ovarian cancer, other studies have recommended postoperative radiation covering the para-aortic lymph nodes [6][7][8][9][10][11][12][27][28][29]. In an early evaluation of our patients, Klein et al [30] showed an improvement of prognosis by postoperative radiation in 24 patients compared to 49 women who underwent adjuvant chemotherapy.…”

Section: Discussionmentioning

confidence: 95%

Management and Prognosis of Primary Fallopian Tube Carcinoma

Rosen¹,

Klein

Hafner³

et al. 1999

Gynecol Obstet Invest

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We retrospectively analyzed 143 women treated in 28 departments from 1980 to 1995, to study the impact of prognostic factors in primary carcinoma of the fallopian tube. Further aims of the study were to evaluate the treatment of fallopian tube carcinoma in Austria. Staging of disease was done according to the modified FIGO system, and grading according to the criteria suggested by Hu et al. The mean age of the patients was 62.5 years. Sixty (42%) tumors were found to be in stage I, 28 (19%) in stage II, 38 (27%) in stage III, and 17 (12%) in stage IV. Radical resection was achieved in 102 (71%) patients. In 122 (85%) women surgery involved removal of the uterus, the adnexa, and/or the omentum or lymph nodes. Postoperatively patients underwent adjuvant therapy consisting of either irradiation (n = 40; 28%) or chemotherapy (n = 70; 49%); 33 women (23%) did not receive any treatment after surgery. The 5-year survival rate for all stages of disease was 43%. The 5-year survival rate was 59% for stages I and II and 19% for stages III and IV. FIGO stage, histologic grading and residual tumor showed an independent prognostic impact in multivariate analysis.

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Primary cancer of the fallopian tube

Cited by 17 publications

References 28 publications

Preoperative Serum hCGβ as a Prognostic Marker in Primary Fallopian Tube Carcinoma

Preoperative Serum hCGβ as a Prognostic Marker in Primary Fallopian Tube Carcinoma

Primary fallopian tube carcinoma: the Queensland experience

Management and Prognosis of Primary Fallopian Tube Carcinoma

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Primary cancer of the fallopian tube

Cited by 17 publications

References 28 publications

Preoperative Serum hCG&beta; as a Prognostic Marker in Primary Fallopian Tube Carcinoma

Preoperative Serum hCG&beta; as a Prognostic Marker in Primary Fallopian Tube Carcinoma

Primary fallopian tube carcinoma: the Queensland experience

Management and Prognosis of Primary Fallopian Tube Carcinoma

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Preoperative Serum hCGβ as a Prognostic Marker in Primary Fallopian Tube Carcinoma

Preoperative Serum hCGβ as a Prognostic Marker in Primary Fallopian Tube Carcinoma