Primary Carcinoid Tumor of the Renal Pelvis Arising From Intestinal Metaplasia: An Unusual Histogenetic Pathway?

Kuba, María G.; Wasserman, Allison; Bridge, Julia A.; Gellert, Lan L.; Hameed, Omar; Giannico, Giovanna A.

doi:10.1097/pai.0000000000000445

Cited by 4 publications

(3 citation statements)

References 69 publications

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“…The renal parenchyma was the apparent source of carcinoids in 76.2% of patients with non-horseshoe kidneys. In two cases, the predominant site was the renal pelvis (4.3%) (Kuba et al 2017, Rudrick et al 1995. The isthmus or paraisthmus area was predominantly implicated in cases with horseshoe kidneys.…”

Section: Discussionmentioning

confidence: 97%

A Rare Case of Neuroendocrine Tumor Following Radical Nephrectomy

Ishaq

Febriansyah

Soetojo

2022

FMI

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Highlights: Rare occurrence of a large, well-differentiated primary renal neuroendocrine tumor in a young man. Identifying primary renal NET from the workup and histological examination of renal tumors needs to be done to understand more of this infrequent type of tumor. Abstract: Neuroendocrine Tumors (NETs) are a diverse range of neoplasms with various biological and histologic features and therapeutic responses. The prevalence of primary renal carcinoids is scarce worldwide. At the moment, complete surgical resection is the primary treatment against primary neuroendocrine tumors of the kidney. Nephrectomy followed by the lymph node dissection is a standard procedure for localized primary renal NETs. Since renal carcinoid tumor is extremely rare, we decided to present a unique case of a 25-years-old male with neuroendocrine renal carcinoid tumor following radical nephrectomy. The results indicated a solid, solitary tumor verified on the frozen section because a postoperative CT–scan showed a recurring mass in the renal fossa following radical nephrectomy. The case emphasized the need to investigate primary renal NET in the workup and histological examination of renal tumors and also contributed to our understanding of this infrequent clinical entity.

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Section: Discussionmentioning

confidence: 97%

A Rare Case of Neuroendocrine Tumor Following Radical Nephrectomy

Ishaq

Febriansyah

Soetojo

2022

FMI

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“…The current research found intestinal metaplasia as a sequelae of chronic infection of renal pelvis, which may be an etiological factor in the occurrence of neuroendocrine cell hyperplasia and carcinoid tumor in the renal pelvicaliceal system. 10 , 42–46 …”

Section: Discussionmentioning

confidence: 99%

Clinical and Pathological Features of Primary Renal Well-Differentiated Neuroendocrine Tumor

Hua¹,

Zhang²

2022

OTT

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Primary carcinoid tumor of the kidney is an extremely rare well-differentiated neuroendocrine tumor, which is generally a low-grade malignant cancer with a good prognosis. Carcinoid tumors are rarely found in the urinary system. Here, we report a 34-year-old woman with primary renal well-differentiated neuroendocrine tumor who underwent nephron sparing surgery and no evidence of recurrence or distant metastasis was found during routine follow-up. We searched the case of renal carcinoid with the search phrase “carcinoid [title] and kidney [title]” and “carcinoid [title] and renal [title]” using the PubMed and restricted the search to articles published in English since 2013. The clinical manifestations, age, sex, tumor size, location, gross pathology, light microscopy and immunohistochemistry were analyzed. A total of 28 cases of renal carcinoid were retrieved from PubMed. Higher proportion of positive labeling of CgA, Syn, NSE and CD56 are most valuable in the diagnosis of primary renal well-differentiated neuroendocrine tumor. At present, radical nephrectomy remains the gold standard in the curative-intent therapy for well-differentiated neuroendocrine carcinoma of kidney, in metastatic renal carcinoid, long-term use of octreotide may be an effective adjuvant therapy.

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“…These tumors could be derived from pancreatic tissue, neural crest, multipotent stem cells, urothelial metaplasia, or metastases from an unknown primary. [ 27 28 ] They tend to occur in association with congenital and acquired renal abnormalities, patients do not usually develop carcinoid syndrome, and around 30% of tumors are incidentally diagnosed. [ 29 ] They are solitary, unilateral, and slow-growing masses larger than 4 cm and advanced at diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Neuroendocrine neoplasms in rare locations: Clinicopathological features and review of the literature

Arco

Sastre

Peinado

et al. 2018

Indian J Endocr Metab

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Introduction:Neuroendocrine tumors (NETs) occur more often in lungs, gastrointestinal tract, or pancreas. Data about terminology and grading of NETs in rare locations are scarce and variable, and they have been reported mainly as case reports.Materials and Methods:We here describe our experience with NETs in unusual locations. We have reviewed all NETs diagnosed in our institution and summarized their clinicopathological features. We have also reviewed the literature and discussed the main characteristics of NETs in each site.Results:Two hundred and forty-three primary NETs were diagnosed. About 55.2% of patients were men and the mean age was 62 years. About 90.7% of NETs were located in lungs, gastrointestinal tract, or pancreas, and 50.8% of them were low-grade tumors. We identified 13 NETs in rare locations: breast, ovary, endometrium, vulva, uterine cervix, extrahepatic biliary tract, kidney, sinonasal tract, and thymus. Three additional tumors were diagnosed by the senior author in other institution. Patients were asymptomatic or presented with nonspecific symptoms. All NETs were treated with surgery and 31% of patients received adjuvant therapy. There were 10 Grade 3 (62.5%), 2 Grade 2 (12.5%), and 4 Grade 1 (25%) tumors. Mean follow-up was 72 months. About 60% of G3 tumors recurred or progressed. G2 tumors were located in breast, and both patients are stable. About 50% of G1 tumors recurred or progressed (both renal NETs).Conclusions:NETs in rare locations are heterogeneous, and their behavior does not seem to correlate absolutely with tumor grade. More studies are needed to clarify the role of proliferation rate in these tumors.

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Primary Carcinoid Tumor of the Renal Pelvis Arising From Intestinal Metaplasia: An Unusual Histogenetic Pathway?

Abstract: This report portrays a unique presentation of carcinoid tumor arising from intestinal metaplasia of the pelvic urothelium, and supports its histogenesis from urothelial intestinal metaplasia and neuroendocrine hyperplasia.

Cited by 4 publications

References 69 publications

A Rare Case of Neuroendocrine Tumor Following Radical Nephrectomy

A Rare Case of Neuroendocrine Tumor Following Radical Nephrectomy

Clinical and Pathological Features of Primary Renal Well-Differentiated Neuroendocrine Tumor

Neuroendocrine neoplasms in rare locations: Clinicopathological features and review of the literature

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