Primary carcinoid tumour of nasal septum

Galm, Tira; Turner, Nicky

doi:10.1017/s0022215108003411

Cited by 8 publications

(6 citation statements)

References 15 publications

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“…They may occur anywhere in the sinonasal tract and are not confined to the cribriform plate. 31,33 That being said, we have seen an occasional case of ONB with a ''carcinoid-like'' appearance with diffuse keratin expression. These cases occur in the superior nasal cavity, have S100-positive sustentacular cells and generally will have focal typical ONB within the neoplasm (see divergent differentiation).…”

Section: Sinonasal Neuroendocrine Carcinomasmentioning

confidence: 86%

Olfactory Neuroblastoma

Faragalla

Weinreb²

2009

Advances in Anatomic Pathology

114

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Olfactory neuroblastoma (ONB) is a malignant neuroectodermal tumor that typically occurs in the superior nasal cavity. It is a distinct entity with features that include nesting, low-grade stippled nuclei, and neurofibrillary stroma with formation of pseudorosettes. It has a distinctive immunoprofile that includes keratin negativity, neuroendocrine marker positivity, and S100 positive sustentacular cells, which surround the nests of tumor in a supportive manner. Although the typical clinicopathologic features leave little room for misinterpretation, the wide variability in this tumor may cause diagnostic difficulty. This includes immunophenotypic diversity or patchy staining with immunomarkers, wide spectrum of grade and histology, posttreatment changes, and occasional divergent differentiation. In addition, problems in sampling, preservation, and clinical localization may make the diagnosis more challenging. A large group of tumors may show morphologic overlap with ONB, with some mimicking low-grade tumors, whereas others mimic high-grade tumors. This differential diagnosis has important treatment and prognostic implications. Further complicating the issue is that many of the mimics themselves may show great morphologic and immunophenotypic variability. This manuscript will review the typical clinical and pathologic features of ONB, address the great variability of ONB in our experience, will focus on the differential diagnosis and report on recent findings in these tumors including molecular genetics where applicable.

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Section: Sinonasal Neuroendocrine Carcinomasmentioning

confidence: 86%

Olfactory Neuroblastoma

Faragalla

Weinreb²

2009

Advances in Anatomic Pathology

114

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“…Recurrence was reported in one patient whose tumor involved nasal cavity, ethmoid sinus, and sphenoid sinus [16]. A disease free follow-up of 4 years has been recorded in another case [17].…”

Section: Clinical Featuresmentioning

confidence: 92%

Neuroendocrine Neoplasms of the Sinonasal Tract: Neuroendocrine Carcinomas and Olfactory Neuroblastoma

Shah

Perez-Ordóñez

2016

Head and Neck Pathol

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Neuroendocrine neoplasms (NENs) can occur in organs or tissues that do not contain neuroendocrine cells normally and do not necessarily imply embryologic derivation from the neuroectoderm; but rather reflect a shared phenotype characterized by the expression of multiple genes encoding both endocrine and neuronal features. NENs are rare in the sinonasal tract and are subdivided into epithelial and neural subtypes based on the presence of keratins or neurofilaments, respectively. Although relatively rare, neuroendocrine carcinomas (NECs) and olfactory neuroblastoma (ONB) are the most common neuroendocrine neoplasms of the sinonasal tract. The focus of this review is to highlight recent developments in the pathology of sinonasal NECs and ONB in light of the upcoming update of the World Health Organization (WHO) 2005 classification of tumors of the head and neck.

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“…Immunohistochemically, S100 positive sustentacular cells are not seen as seen in our study in ONB. 20 …”

Section: Discussionmentioning

confidence: 99%

Olfactory neuroblastoma: A clinicopathological experience of a rare entity from Pakistan

et al. 2016

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Objectives:To present the clinicopathological experience of Olfactory Neuroblastoma (ONB) with emphasis on histopathological and immunohistochemical features.Methods:A descriptive cross-sectional study was done on 36 cases of ONB, selected by non-probability purposive sampling. Theses cases of ONB were retrieved and reviewed from surgical pathology database of Aga Khan University Hospital reported between January 1993 and March 2015.Results:Tumor size and age of presentation was wide in range without any distinct bimodal distribution. Nasal cavity was most common site along with involvement of paranasal sinuses. More than 50% cases had Kadish stage A. Microscopically, most cases were Grade-1 and majority showed partial or complete lobular architecture. Neurofibrillary matrix was observed in 2/3rd of cases. Among immunohistochemical markers, Neuron Specific Enolase was most frequently expressed. Unusual positive expression of Cytokeratin AE1/AE3 and Cytokeratin CAM5.2 was also seen focally in few cases.Conclusion:The ONB has great variability of histological and clinical presentation, and immunohistochemical markers are useful to differentiate from more common small round blue cell tumours of nasal cavity.

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Primary carcinoid tumour of nasal septum

Cited by 8 publications

References 15 publications

Olfactory Neuroblastoma

Olfactory Neuroblastoma

Neuroendocrine Neoplasms of the Sinonasal Tract: Neuroendocrine Carcinomas and Olfactory Neuroblastoma

Olfactory neuroblastoma: A clinicopathological experience of a rare entity from Pakistan

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