Primary carcinoma of female urethra: Review of 20 cases

Kamat, Murali R.; Kulkarni, Jagdeesh N.; Dhumale, Rajendra G.

doi:10.1002/jso.2930160202

Cited by 13 publications

(4 citation statements)

References 4 publications

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“…After reviewing the titles, abstracts and full texts, we selected 92 studies for qualitative synthesis (Fig. 1) [1,2,4–6,8–95].…”

Section: Resultsmentioning

confidence: 99%

“…In a subsequent study by Kamat et al. [43], 14 patients underwent surgery alone, with type of surgery not specified. In that study, the 5‐year OS rate was 21%, offering insights into the effectiveness of surgery as a standalone treatment.…”

Section: Resultsmentioning

confidence: 99%

“…In a subsequent study by Kamat et al [43], 14 patients underwent surgery alone, with type of surgery not specified.…”

Section: Effectiveness and Harms Of Surgery Alone Among Patients With...mentioning

confidence: 99%

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Urethral cancer: a comprehensive review endorsed by the Global Society of Rare Genitourinary Tumours

García‐Perdomo,

Dávila‐Raigoza,

Summers

et al. 2024

BJU International

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ObjectiveTo determine the effectiveness and adverse effects of urethrectomy alone or as part of multimodal therapy (MMT).MethodsA comprehensive search was conducted across MEDLINE (OVID), EMBASE, LILACS and the Cochrane Central Register of Controlled Trials (CENTRAL) databases, from their inception to the present date. The study cohort comprised individuals aged 16 years and older diagnosed with urethral tumours at any stage who underwent either isolated urethrectomy or urethrectomy as an integral component of MMT.ResultsNinety‐two studies comprising 25 480 patients met the inclusion criteria. Surgical outcomes for urethral cancer vary considerably, with 5‐year overall survival (OS) ranging from 10% to 68% based on disease extent, approach, and gender. Radiotherapy (RT) alone provides 5‐year OS of approximately 40%. Combined regimens provide better outcomes compared to single modalities, including reduced recurrence and enhanced survival. However, trimodal therapy showed survival benefits only for urothelial subtypes, indicating the need to tailor management according to cancer type. MMT with neoadjuvant chemotherapy prior to surgery demonstrated the most consistent survival gains.ConclusionsThe management of urethral cancer demands a nuanced, personalised approach, accounting for factors such as tumour location, sex, and tumour stage. MMT combining surgery, chemotherapy and RT has shown the ability to enhance outcomes in advanced disease. More extensive collaborative studies through specialised centres are imperative to advance evidence‐based protocols and refine treatment in order to improve survival.

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“…After reviewing the titles, abstracts and full texts, we selected 92 studies for qualitative synthesis (Fig. 1) [1,2,4–6,8–95].…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Urethral cancer: a comprehensive review endorsed by the Global Society of Rare Genitourinary Tumours

García‐Perdomo,

Dávila‐Raigoza,

Summers

et al. 2024

BJU International

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“…The stage of the tumor is critical for prognostication [13]. Hopkins et al [14] reported on 15 patients with malignant urethral neoplasms.…”

Section: Discussionmentioning

confidence: 99%

Primary Transitional Cell Carcinoma of the Female Urethra with Features of Clear Cell Adenocarcinoma

et al. 1985

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Primary malignant urethral neoplasms are unusual in women. Those of mixed histologic type are so rare as to define adequate documentation. We report the case of an elderly black woman with an urethral carcinoma which had features of a transitional cell carcinoma as well as clear cell adenocarcinoma. The histologic and ultrastructural features are presented and the histogenesis is discussed. Although the patient had both high grade and high stage disease and failed initially after external beam radiation therapy, she is alive and well, without evidence of recurrent disease, 19 months after anterior exenteration.

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Malignant Tumours

Barua

1990

Tumours of the Female Lower Genital Tract

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Primary carcinoma of female urethra: Review of 20 cases

Cited by 13 publications

References 4 publications

Urethral cancer: a comprehensive review endorsed by the Global Society of Rare Genitourinary Tumours

Urethral cancer: a comprehensive review endorsed by the Global Society of Rare Genitourinary Tumours

Primary Transitional Cell Carcinoma of the Female Urethra with Features of Clear Cell Adenocarcinoma

Malignant Tumours

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