Primary cardiac angiosarcoma initially diagnosed on pericardial fluid cytology with histology and autopsy correlation

Abstract

Primary cardiac angiosarcoma is an exceedingly rare high-grade malignancy of the heart originating from endothelial cells, with a predilection for the right atrium in male. Clinical diagnosis is extremely challenging because of the nonspecific symptoms and radiological findings. Although almost always presenting with massive

Cardiac calcified amorphous tumour: an unusual aetiology for recurrent cardioembolic strokes

“…Unusual clinical manifestations broaden the clinical spectrum and pose diagnostic challenges. For example, primary cardiac angiosarcoma presents with massive recurrent pericardial effusion, but pericardial fluid analysis for malignant cells often does not provide the diagnosis, which often is made postmortem 17. A patient’s age can help narrow the differential diagnosis: rhabdomyoma, fibroma, teratoma, are more common in children; myxomas, lipoma and fibroelastoma are typically seen in adults 16.…”