Primary cardiac diffuse large B-cell lymphoma in immunocompetent patients: clinical, histologic, immunophenotypic, and genotypic features of 3 cases

Soon, Gwyneth; Ow, Samuel G.W.; Chan, Hian Li Esther; Ng, Siok Bian; Wang, Shi

doi:10.1016/j.anndiagpath.2016.05.005

Cited by 16 publications

(13 citation statements)

References 36 publications

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“…Primary cardiac lymphoma is an extremely rare subset of non-Hodgkin's lymphoma, involving only the heart and/or the pericardium. The majority of cardiac lymphomas are B-cell neoplasms [ 21 ] . T-cell lymphoma was found in only 5% of all primary cardiac lymphoma types in a large literature review [ 22 ] .…”

Section: Discussionmentioning

confidence: 99%

Outcomes After Surgical Resection of Primary Non-Myxoma Cardiac Tumors

Boyacıoğlu

Dönmez

et al. 2018

Braz J Cardiovasc Surg

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ObjectivePrimary cardiac tumors are rare lesions with different histological type. We reviewed our 17 years of experience in the surgical treatment and clinical results of primary non-myxoma cardiac tumors.MethodsBetween July 2000 and February 2017, 21 patients with primary cardiac tumor were surgically treated in our institution. The tumors were categorized as benign non-myxomas and malignants. Data including the demographic characteristics, details of the tumor histology and grading, cardiac medical and surgical history, surgical procedure of the patients were obtained from the hospital database.ResultsEleven patients were diagnosed with benign non-myxoma tumor (male/female:7/4), ranging in age from 10 days to 74 years (mean age 30.9±26.5 years). Papillary ﬁbroelastoma was the most frequent type (63.6%). There were two early deaths in benign group (all were rhabdomyoma), and mortality rate was 18%. The mean follow-up period was 69.3±58.7 months (range, 3 to 178 months). All survivals in benign group were free of tumor-related symptoms and tumor relapses. Ten patients were diagnosed with malignant tumor (sarcoma/lymphoma:8/2, male/female:3/7), ranging in age from 14 years to 73 years (mean age 44.7±18.9 years). Total resection could be done in only three (30%) patients. The mean follow-up period was 18.7±24.8 months (range, 0-78 months). Six patients died in the first 10 months.ConclusionComplete resection of the cardiac tumors, whenever possible, is the main goal of surgery. Surgical resection of benign cardiac tumors is safe, usually curative and provides excellent long-term prognosis. On the contrary, malignant cardiac tumors still remain highly lethal.

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Section: Discussionmentioning

confidence: 99%

Outcomes After Surgical Resection of Primary Non-Myxoma Cardiac Tumors

Boyacıoğlu

Dönmez

et al. 2018

Braz J Cardiovasc Surg

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“…The patient's main clinical manifestations were facial edema, tiring chest tightness and dyspnea, with jugular vein lling, and no edema of lower limbs. All 3 of cases reported by Gwyneth Soon, MBBS et al [2] had right heart involvement. Only 1 case involved all 4 chambers of the heart.…”

Section: Discussionmentioning

confidence: 88%

Primary cardiac CD5-positive diffuse large B-cell lymphoma:A case report and review of literature

Wang

Yang

Gao

et al. 2021

Preprint

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Background：Primary cardiac CD5 positive diffuse large B-cell lymphoma (CD5+ DLBCL) is a rare subtype of DLBCL with many diagnostic challenges. The case is reported, along with a review of several characteristics of the disease. Case presentation：We described a 64-year-old female who presented with a 12-month history of cough, and a mass in the right atrium observed on imaging studies that extended into the right ventricle. Conclusions：CD5+ DLBCL was confirmed finally by pathological examination of the cardiac biopsy. The patient responded well to the modified R-CHOP regime. The poor prognosis factors include CD5 positive, non-GCB immunophenotype, myc, bcl-2 and bcl-6 gene rearrangements etc. Early diagnosis and aggressive treatment play a key role on improving the prognosis of primary cardiac CD5+ DLBCL.

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“…It may also cause various arrhythmias such as sinus tachycardia, atrioventricular block, atrial fibrillation, and ventricular fibrillation. Cases with syncope as the initial manifestation were also reported 9,10 . Congestive heart failure was observed in more than half of PCL patients according to the report.…”

Section: Discussionmentioning

confidence: 93%

The diagnosis of a giant cardiac malignant lymphoma in the right ventricle: a case report

Zhao

Lei

et al. 2021

ESC Heart Failure

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Cardiac lymphoma is extremely rare in patients with normal immune function and difficult to identify through routine examinations in patients with atypical clinical manifestations, making early diagnosis very difficult. We reported a 71-year-old male patient who was repeatedly diagnosed of pulmonary infection, suspected lung tumour, and Kimura disease in other hospital due to cough, expectoration, and dyspnoea. Later on, the patient visited our hospital due to heart failure and epistaxis. Transthoracic echocardiogram confirmed the presence of a space-occupying lesion in the right heart, cardiac magnetic resonance imaging preliminarily determined the nature of this lesion, finally, 18 F-fluorodeoxyglucose positron-emission tomography/computed tomography, and nasal mass biopsy confirmed the diagnosis of cardiac malignant lymphoma, and the pathological type was diffuse large B-cell lymphoma.

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Primary cardiac diffuse large B-cell lymphoma in immunocompetent patients: clinical, histologic, immunophenotypic, and genotypic features of 3 cases

Cited by 16 publications

References 36 publications

Outcomes After Surgical Resection of Primary Non-Myxoma Cardiac Tumors

Outcomes After Surgical Resection of Primary Non-Myxoma Cardiac Tumors

Primary cardiac CD5-positive diffuse large B-cell lymphoma:A case report and review of literature

The diagnosis of a giant cardiac malignant lymphoma in the right ventricle: a case report

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