Primary cardiac lymphoma presenting as atrial flutter and total heart block

Bulum, Joško; Banfić, Ljiljana; Strozzi, Maja; Aurer, Igor; Jelašić, Dražen

doi:10.1007/s00380-006-0924-2

Cited by 22 publications

(23 citation statements)

References 5 publications

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“…The patient presented with fatal VT shortly after starting his first round of chemotherapy, although he did not have any cardiac symptoms or evidence of an arrhythmia before chemotherapy. The association of VT with malignant lymphoma was previously reported in patients with primary or secondary cardiac lymphoma (6)(7)(8). However, most of them were reported as presenting with VT at the time of admission or diagnosis.…”

Section: Discussionmentioning

confidence: 83%

Cardiac Involvement in CD56 Negative Primary Pancreatic Extranodal NK/T-cell Lymphoma, Nasal Type, Presenting with Ventricular Tachycardia during the Early Stages of Chemotherapy

Baek

Shin

et al. 2014

Intern. Med.

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We herein report the case of a 23-year-old man who presented with recurrent pancreatitis and was diagnosed with primary pancreatic extranodal natural killer/T-cell lymphoma, nasal type, involving the right ventricle. The cardiac involvement was screened and confirmed by transthoracic echocardiography (TTE), cardiac magnetic resonance imaging and fluorodeoxyglucose positron emission tomography. Although the patient did not have any cardiac symptoms or evidence of arrhythmia before chemotherapy, he presented with fatal newly developed ventricular tachycardia during the early stages of chemotherapy. The follow-up TTE after his chemotherapy demonstrated markedly decreased thickness of the invaded myocardium, thus suggesting that the myocardium infiltrated by lymphoma cells might become vulnerable to fatal arrhythmia with tumor regression.Key words: extranodal NK-T cell lymphoma, nasal type, heart neoplasms, ventricular tachycardia Case ReportA 23-year-old man was admitted due to intermittent abdominal pain of 2 months duration. He was treated for recurrent pancreatitis and did not have any other previous medical history or alcohol history. The chest X-ray demonstrated mild cardiomegaly. Electrocardiography (ECG) showed ST-segment elevation in the V1, V2 and V3 leads (Fig. 1). The QT interval on the ECG was within the normal range. Telemetry did not reveal any arrhythmia, such as a premature ventricular complex (PVC) or ventricular tachycardia (VT), and the cardiac enzyme was normal.On an abdominal CT, the pancreas was enlarged with peripancreatic infiltration, and the distal tail portion of the pancreas was not observed. An endoscopic ultrasound guided needle biopsy of the pancreas showed diffuse interstitial infiltration of atypical lymphoid cells with extensive necrosis. Immunophenotypically, the infiltrate was composed predominantly of T-cells, which were cytoplasmic CD3 (cyCD3) positive. Although the cells were CD56 negative, there was nuclear atypia and diffuse positive staining in the

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Section: Discussionmentioning

confidence: 83%

Cardiac Involvement in CD56 Negative Primary Pancreatic Extranodal NK/T-cell Lymphoma, Nasal Type, Presenting with Ventricular Tachycardia during the Early Stages of Chemotherapy

Baek

Shin

et al. 2014

Intern. Med.

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“…ECG changes are summarized in Table 2. Complete AVblock is the ECG change which is most frequently observed in patients with PCL [12,18,[38][39][40][41]. This electrocardiographic abnormality can be unmasked by noncardiac surgery [18].…”

Section: -Lead Ecgmentioning

confidence: 99%

Primary cardiac lymphoma

Miguel

Bestetti

2011

International Journal of Cardiology

142

125

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“…PCL is defined as a non-Hodgkin's lymphoma (NHL) confined to the heart or pericardium or NHL in which bulk of the tumour is located in the heart [1]. The incidence of cardiac lymphoma in postmortem studies ranges from 0.15% to 1% [2].…”

Section: Discussionmentioning

confidence: 99%

Primary cardiac lymphoma masquerading as right atrial myxoma causing complete heart block—a case report

Raju

Ramanathan

Lakshmanan

et al. 2010

Indian J Thorac Cardiovasc Surg

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Secondary involvement of the heart and pericardium by systemic lymphoma is well documented. Primary Cardiac lymphomas (PCL) are extremely rare. Incidence of PCL is increasing in immunocompromised patients. However PCL in immunocompetent is much rarer. We report such a case of PCL in an immunocompetent elderly female masquerading as right atrial myxoma causing complete heart block which was surgically debulked successfully. Her rhythm resumed to Sinus rhythm following surgical debulking. Immunohistochemistry of the excised tumour revealed Diffuse Large B cell lymphoma. With combination chemotherapy, she is symptom free on six months follow up.

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Primary cardiac lymphoma presenting as atrial flutter and total heart block

Cited by 22 publications

References 5 publications

Cardiac Involvement in CD56 Negative Primary Pancreatic Extranodal NK/T-cell Lymphoma, Nasal Type, Presenting with Ventricular Tachycardia during the Early Stages of Chemotherapy

Cardiac Involvement in CD56 Negative Primary Pancreatic Extranodal NK/T-cell Lymphoma, Nasal Type, Presenting with Ventricular Tachycardia during the Early Stages of Chemotherapy

Primary cardiac lymphoma

Primary cardiac lymphoma masquerading as right atrial myxoma causing complete heart block—a case report

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