Primary Care of the Patient with Asthma

Lenaeus, Michael J.; Hirschmann, Jan V.

doi:10.1016/j.mcna.2015.05.007

Cited by 4 publications

(3 citation statements)

References 73 publications

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“…For more than a decade, the relationship between these diseases has been sometimes referred to as 'the atopic march' [3][4][5][6][7]. The basis for the atopic march lies in the theory that all allergic diseases may share a common ground [8][9][10] and that this cohesion should be considered in their management [11]. In particular the early childhood phase, where food allergy and atopic dermatitis are often present, is a crucial period for a person to develop asthma and/or allergic rhinitis [12].…”

Section: Introductionmentioning

confidence: 99%

Burden and socioeconomics of asthma, allergic rhinitis, atopic dermatitis and food allergy

Dierick

Molen

Blok

et al. 2020

Expert Review of Pharmacoeconomics & Outcomes Research

229

157

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Introduction: Asthma, allergic rhinitis, atopic dermatitis, and food allergy affect approximately 20% of the global population. Few studies describe the burden of the totality of these diseases and only a handful studies provide a comprehensive overview of the socioeconomic impact of these diseases. Areas covered: For this narrative review, we searched Pubmed using selected keywords and inspected relevant references using a snowballing process. We provide an overview of the socioeconomic burden of allergic diseases (in particular, asthma, allergic rhinitis, atopic dermatitis, and food allergy). The focus of this review is on their epidemiology (incidence, prevalence), burden (disability-adjusted life years, quality of life), and direct and indirect costs (absenteeism and presenteeism). We have put special emphasis on differences between countries. Expert commentary: Both the prevalence and the burden of allergic diseases are considerable with prevalence varying between 1% and 20%. We identified a plethora of studies on asthma, but studies were generally difficult to compare due to the heterogeneity in measures used. There were only few studies on the burden of food allergy; therefore, more studies on this allergy are required. For future studies, we recommend standardizing epidemiologic, socioeconomic impact, and quality of life measures of allergic diseases.

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Section: Introductionmentioning

confidence: 99%

Burden and socioeconomics of asthma, allergic rhinitis, atopic dermatitis and food allergy

Dierick

Molen

Blok

et al. 2020

Expert Review of Pharmacoeconomics & Outcomes Research

229

157

View full text Add to dashboard Cite

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“…However, the effects of vitamin D supplementation on all allergic diseases in children have not been examined. The common comorbidities and shared pathogenesis of allergic diseases have led to the need for a common therapeutic approach [ 15 , 16 , 17 ]. Therefore, a holistic overview of the treatment effect of vitamin D on childhood allergic diseases is necessary.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Supplementation and Allergic Diseases during Childhood: A Systematic Review and Meta-Analysis

Zhou

Zhang

et al. 2022

Nutrients

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We performed a systematic review and meta-analysis to investigate the effects of vitamin D (VitD) supplementation on children with allergic diseases. MEDLINE, Embase, Web of Science, the Cochrane library, and three Chinese databases were searched up to 15 August 2022. Randomized controlled trials (RCTs) comparing a VitD supplementation versus a placebo for children with allergic diseases were included. Thirty-two RCTs with 2347 participants were included. VitD supplementation did not reduce the risk of asthma exacerbations in children compared with placebo overall (risk ratio (RR) = 0.84, 95% confidence interval (CI): 0.65 to 1.08, p = 0.18), but reduced the risk of asthma exacerbation in children with baseline serum 25(OH)D of <10 ng/mL compared with placebo (RR = 0.48, 95% CI: 0.28 to 0.83, p = 0.009). VitD supplementation significantly reduced Scoring Atopic Dermatitis or the Eczema Area and Severity Index scores in children with atopic dermatitis compared with placebo (standard mean difference = −0.5, 95% CI: −0.87 to −0.12, p = 0.009). VitD supplementation also reduced the symptom-medication score in children with allergic rhinitis compared with placebo (mean (standard deviation): 43.7 (3.3) vs. 57.8 (4.4), p = 0.001). In conclusion, VitD supplementation did not reduce asthma exacerbation risk in children overall but may reduce asthma exacerbation risk in children with serum 25(OH)D concentration < 10 ng/mL. VitD supplementation reduces the severity of atopic dermatitis and symptoms of allergic rhinitis in children.

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“… 2 Owing to the variability and heterogeneity of clinical features and the limited access to lung functional tests, COLD remains often underdiagnosed, especially in primary care. 2 – 4 …”

Section: Introductionmentioning

confidence: 99%

Chronic obstructive lung disease “expert system”: validation of a predictive tool for assisting diagnosis

Braido

Santus

Corsico

et al. 2018

COPD

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PurposeThe purposes of this study were development and validation of an expert system (ES) aimed at supporting the diagnosis of chronic obstructive lung disease (COLD).MethodsA questionnaire and a WebFlex code were developed and validated in silico. An expert panel pilot validation on 60 cases and a clinical validation on 241 cases were performed.ResultsThe developed questionnaire and code validated in silico resulted in a suitable tool to support the medical diagnosis. The clinical validation of the ES was performed in an academic setting that included six different reference centers for respiratory diseases. The results of the ES expressed as a score associated with the risk of suffering from COLD were matched and compared with the final clinical diagnoses. A set of 60 patients were evaluated by a pilot expert panel validation with the aim of calculating the sample size for the clinical validation study. The concordance analysis between these preliminary ES scores and diagnoses performed by the experts indicated that the accuracy was 94.7% when both experts and the system confirmed the COLD diagnosis and 86.3% when COLD was excluded. Based on these results, the sample size of the validation set was established in 240 patients. The clinical validation, performed on 241 patients, resulted in ES accuracy of 97.5%, with confirmed COLD diagnosis in 53.6% of the cases and excluded COLD diagnosis in 32% of the cases. In 11.2% of cases, a diagnosis of COLD was made by the experts, although the imaging results showed a potential concomitant disorder.ConclusionThe ES presented here (COLDES) is a safe and robust supporting tool for COLD diagnosis in primary care settings.

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Primary Care of the Patient with Asthma

Cited by 4 publications

References 73 publications

Burden and socioeconomics of asthma, allergic rhinitis, atopic dermatitis and food allergy

Burden and socioeconomics of asthma, allergic rhinitis, atopic dermatitis and food allergy

Vitamin D Supplementation and Allergic Diseases during Childhood: A Systematic Review and Meta-Analysis

Chronic obstructive lung disease “expert system”: validation of a predictive tool for assisting diagnosis

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Primary Care of the Patient with Asthma

Cited by 4 publications

References 73 publications

Burden and socioeconomics of asthma, allergic rhinitis, atopic dermatitis and food allergy

Burden and socioeconomics of asthma, allergic rhinitis, atopic dermatitis and food allergy

Vitamin D Supplementation and Allergic Diseases during Childhood: A Systematic Review and Meta-Analysis

Chronic obstructive lung disease &ldquo;expert system&rdquo;: validation of a predictive tool for assisting diagnosis

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Product

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Chronic obstructive lung disease “expert system”: validation of a predictive tool for assisting diagnosis