O ver the last decades, 2 main techniques for measuring blood pressure (BP) out of the physician's office have gained increasing importance in the clinical approach to arterial hypertension, both being supported by recent international hypertension management guidelines. 1,2 These techniques are home BP monitoring (HBPM) and 24-hour ambulatory BP monitoring (ABPM). Their diffusion in clinical practice has been favored by a number of factors, including on one side technical progress and wider availability of accurate HBPM and ABPM devices and on the other side the increasing awareness of the limitations of office BP (Table 1). 3,4 Office BP is in fact characterized by a random error affecting casual BP readings and by a systematic error related to the patient's alerting reaction to the measurement procedure and setting, known as "white coat effect." 1,3 Both ABPM and HBPM are devoid of these limitations and, thus, provide more stable and reproducible information on BP values, 5 which is also of greater prognostic relevance 6 -21 (Table 2). Furthermore, office BP readings are unable to collect information on BP during a subject's usual activities and over a long period of time, 22 an important limitation in everyday management of hypertensive subjects that can be overcome by out-of-office BP monitoring.ABPM was initially confined to specialized hypertension centers because of its relatively high cost, but over the years its availability has steadily increased. HBPM, on the other hand, has been used rather reluctantly by physicians in routine management of hypertensive patients. Although its potential usefulness in clinical practice was acknowledged many years ago, 23 its application has been limited until the end of last century by the need to use auscultatory measurements, an approach that is difficult to apply correctly, 24 particularly in the home setting, and prone to providing inaccurate information, especially when using aneroid devices. 25 A major breakthrough came with the introduction of inexpensive, easy-to-use, and accurate automated oscillometric BP measuring devices, leading to a widespread use of HBPM. At present, in developed countries Ϸ70% of hypertensive patients regularly assess their BP at home, 26,27 and the clinical usefulness of this approach is generally acknowledged by physicians. 28,29 Such a rapidly growing diffusion of HBPM in clinical practice has inevitably raised the question of whether HBPM