Primary care treatment guidelines for skin infections in Europe: congruence with antimicrobial resistance found in commensal Staphylococcus aureusin the community

Bijnen, E.M.E. van; Paget, W J; Heijer, Casper D. J. den; Stobberingh, Ellen E.; Bruggeman, Cathrien A.; Schellevis, François G.

doi:10.1186/s12875-014-0175-8

Cited by 24 publications

(15 citation statements)

References 33 publications

(46 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in around one of six participants no antimicrobial resistant CoNS isolates were found. The highest prevalence of antimicrobial resistance was towards erythromycin, fusidic acid, tetracycline and clindamycin, all antimicrobial agents commonly prescribed in primary health care to treat respiratory tract and skin infections (16). A recent Portuguese study on community CoNS reported overall higher prevalence of resistance than in our Norwegian isolates, and showed a higher prevalence of resistance towards agents commonly prescribed antibiotics in primary care (12).…”

Section: Discussionmentioning

confidence: 58%

Antimicrobial susceptibility and body site distribution of community isolates of coagulase‐negative staphylococci

Cavanagh

Wolden

Heise

et al. 2016

APMIS

View full text Add to dashboard Cite

15The primary aim of this study was to determine antimicrobial resistance in coagulase negative staphylococci (CoNS) from healthy 16 adults in the community. Healthy adults (n=114) were swabbed on six body sites; both armpits, both knee pits and both sides of the 17 groin. Species determination was performed using MALDI-TOF and susceptibility testing for eleven relevant antimicrobials was 18 performed by the disc diffusion method and minimal inhibitory concentration gradient test. 19In total, 693 CoNS-isolates were identified. Susceptibility testing was done on 386 isolates; one CoNS from each species found on 20 each participant from the different body sites. The prevalence of antimicrobial resistance in the CoNS isolates were; erythromycin 21 (24.6%), fusidic acid (19.9%), tetracycline (11.4%),clindamycin (7.8%), gentamicin (6.2%) and cefoxitin (4.1%). Multidrug resistance 22 was observed in 5.7% of the isolates. Staphylococcus epidermidis and S. hominis were the first and second most prevalent species on 23 all three body sites. We conclude that CoNS isolates from healthy adults in the community have a much lower prevalence of 24 antimicrobial resistance than reported in nosocomial CoNS isolates. Still, we believe that levels of resistance in community CoNS 25 should be monitored as the consumption of antimicrobials in primary care in Norway is increasing. 26 27Running head: Antimicrobial susceptibility of community coagulase negative staphylococci . 28

show abstract

Section: Discussionmentioning

confidence: 58%

Antimicrobial susceptibility and body site distribution of community isolates of coagulase‐negative staphylococci

Cavanagh

Wolden

Heise

et al. 2016

APMIS

View full text Add to dashboard Cite

show abstract

“…As antibiotic resistance against classical antibiotics is rapidly emerging, alternative treatment options are desperately needed [456]. Staphefekt SA.100 is a recombinant phage endolysin for topical skin application that specifically binds to the cell wall of S. aureus and cleaves bonds in the peptidoglycan wall, resulting in bacterial cell death [7].…”

Section: Introductionmentioning

confidence: 99%

Successful Treatment of Chronic Staphylococcus aureus-Related Dermatoses with the Topical Endolysin Staphefekt SA.100: A Report of 3 Cases

2017

View full text Add to dashboard Cite

Staphylococcus aureus plays an important role in skin and soft tissue infections and contributes to the pathophysiology of complex skin disorders such as atopic dermatitis. Bacterial resistance against commonly used antibiotics has increased considerably in the last decades demanding alternative treatment approaches. We present 3 cases where patients with chronic and recurrent S. aureus-related dermatoses were successfully treated with Staphefekt SA.100. Staphefekt SA.100 is a recombinant phage endolysin for topical skin application that specifically targets both methicillin-sensitive and methicillin-resistant S. aureus. As a consequence of its specific mechanism of action, bacterial resistance is unlikely to develop. In our 3 cases, resistance induction was not observed. Our results indicate that targeted treatment with Staphefekt might be an attractive alternative for (long-term) classical antibiotic therapy, and confirmatory randomized controlled trials are warranted to evaluate its clinical efficacy and safety.

show abstract

“…Staphylococcus aureus is one of the most important serious opportunistic human pathogens involved in nosocomial infections [1,2]. Resistance to methicillin primarily derives from acquisition of the mecA gene, which encodes a modified penicillin‐binding protein (PBP2a) with low affinity for β‐lactams [2].…”

Section: Introductionmentioning

confidence: 99%

Distribution of genes encoding resistance to aminoglycoside modifying enzymes in methicillin‐resistant Staphylococcus aureus (MRSA) strains

Khosravi

Jenabi

Montazeri

2017

The Kaohsiung J of Med Scie

View full text Add to dashboard Cite

Today Methicillin-Resistant Staphylococcus aureus (MRSA) have acquired multiple resistance to a wide range of antibiotics including aminoglycosides. So, this study was aimed to investigate the rate of aminoglycoside resistance and the frequency of aminoglycoside resistance mediated genes of aac(Ia)-2, aph(3)-IIIa and ant(4')-Ia among MRSA strains. A total of 467 staphylococci isolates were collected from various clinical samples. S. aureus strains were identified by standard culture and identification criteria and investigating of presence of 16S rRNA and nuc genes. Cefoxitin disk diffusion, and oxacillin-salt agar screening methods were used to detect the MRSA strains with subsequent molecular identification for the presence of mecA gene. Antibiotic susceptibility of MRSA strains against aminoglycoside antibiotics was evaluated by using agar disk diffusion method. Multiplex PCR for the presence of aac(Ia)-2, aph(3)-IIIa and ant(4')-Ia encoding genes for aminoglycosides were performed for MRSA strains. From total staphylococci tested isolates, 262 (56.1%) were identified as S. aureus, of which 161 (61.45%) were detected as MRSA and all comprised mecA gene. The resistance pattern of MRSA strains to aminoglycoside antibiotics were: gentamicin 136 (84.5%); amikacin 125 (77.6%); kanamycin 139 (86.3%); tobramycin 132 (82%); and neomycin 155 (96.3%). The frequency of aac(Ia)-2, aph(3)-IIIa, and ant(4')-Ia genes among MRSA strains, were 64%, 42% and 11.8% respectively. In conclusion, as MRSA strains are of great concern in human infections, the results of present study could provide a useful resource for health sectors for choosing appropriate antibiotics for the effective treatment of infections due to MRSA strains.

show abstract

Primary care treatment guidelines for skin infections in Europe: congruence with antimicrobial resistance found in commensal Staphylococcus aureusin the community

Cited by 24 publications

References 33 publications

Antimicrobial susceptibility and body site distribution of community isolates of coagulase‐negative staphylococci

Antimicrobial susceptibility and body site distribution of community isolates of coagulase‐negative staphylococci

Successful Treatment of Chronic Staphylococcus aureus-Related Dermatoses with the Topical Endolysin Staphefekt SA.100: A Report of 3 Cases

Distribution of genes encoding resistance to aminoglycoside modifying enzymes in methicillin‐resistant Staphylococcus aureus (MRSA) strains

Contact Info

Product

Resources

About