Primary central nervous system lymphoma in japan: a nationwide survey

Increasing incidence and continued dismal outcome of primary central nervous system lymphoma in Norway 1989–2003

“…However, like in many other studies, good performance status and young age had a favorable impact on survival 13,24,[39][40][41][42] ; patients who received only symptomatic therapy had shorter survival [18][19][20] and combined chemotherapy and radiotherapy was superior to chemotherapy alone 43 and radiotherapy alone. 44 We observed an estimated median survival of 44 months with combined chemotherapy and radiotherapy compared with a median survival of 9 months with radiotherapy alone and 4 months with chemotherapy alone, which led to fatal complications in 5 of 20 patients (25%).…”

“…These survival rates are in the lower range of those reported by others. 15,16,18,19,41,42,44 In part, this may be because there are fewer patients aged 50 years in populationbased material like that used in the current study compared with institution-based materials (eg, 14% of patients in our material compared with 30% of patients in material from a tertiary referral center 42 ). Although it was not significant in our material, the omission of HD MTX in the chemotherapy regimen tended to reduce survival (hazard ratio, 1.50; 95% CI, 0.76-2.96; P 5 .24), which is in accordance with studies that reported a significant impact of HD MTX with hazard ratios of 2.3 29 and 1.48.…”

Primary Central Nervous System Lymphoma: A Clinicopathological and Cytomorpholgical Study from A Tertiary Care Centre in Chennai, India

“…2005; Zhang et al, 2010;Gelabert-González et al, 2012). A nationwide survey of PCNSL in Japan during the period 2000-2004 revealed that T-cell PCNSL accounted for 1.7% of all cases (Shibamoto et al, 2008), whereas a similar earlier study (1985)(1986)(1987)(1988)(1989)(1990)(1991)(1992)(1993)(1994) from the same country showed a higher figure of 8.5% (Hayabuchi et al, 1999).…”

“…A definite decline is evident since about 48% of CNS lymphoma cases were associated with AIDS in the period 1990-1995 (Shiels et al, 2011). However studies from Asia have not shown any significant association of PCNSL with AIDS in the past or in the present (Hayabuchi et al, 1999;Sarkar et al, 2005;Shibamoto et al, 2008;Pasricha et al, 2011).…”

Primary Central Nervous System Lymphoma in Miyazaki, Southwestern Japan, a Human T-Lymphotropic Virus Type-1 (HTLV-1)-Endemic Area: Clinicopathological Review of 31 Cases

“…7,8 In addition to B-PCNSL, the WHO Classification of Tumours of the CNS also states that TPCNSLs constitute approximately 2-5% of all PCNSLs in Western countries and 8-14% in Japan. 6 These data of a high prevalence of T-PCNSL listed in the WHO Classification of Tumours of the CNS 6 were cited from a report by Hayabuchi et al as 8.5% among 234 PCNSLs assessed using a panel of T/B-cell markers 9 and a report by Hayakawa et al as 14% among 21 PCNSLs assessed by immunohistochemical techniques. 10 In other East Asian countries, the T-PCNSL prevalence was reported as 16.…”