Primary central nervous system T‐cell lymphoma with a predominant CD8 immunophenotype

Novak, Joseph A.; Katzin, William E.

doi:10.1002/1097-0142(19950415)75:8<2180::aid-cncr2820750824>3.0.co;2-#

Cited by 12 publications

(2 citation statements)

References 40 publications

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“…[ 4 - 6 , 13 , 29 , 32 ] T-cell PCNSL often presents as a single supratentorial lesion. [ 4 - 6 , 10 , 11 , 18 , 23 , 33 , 35 , 36 , 38 - 41 , 43 , 44 , 46 , 53 ]…”

Section: Discussionmentioning

confidence: 99%

Primary peripheral T-cell central nervous system lymphoma

Bird

Traylor

Thomas

et al. 2021

Surgical Neurology International

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Background: Primary peripheral T-cell central nervous system lymphoma (PCNSL) is a rare, aggressive tumor that arises in the craniospinal axis and has an increased risk in individuals who are immunocompromised. This lesion often mimics other benign and malignant processes on radiographic imaging, leading to misdiagnosis and delays in treatment. We present a case of a patient with a history of Sjögren’s syndrome and progressive neurologic symptoms who underwent craniotomy for diagnosis. Case Description: A 61-year-old woman with a history of Sjögren’s syndrome, progressive aphasia, left facial droop, and right-sided paresthesias for 4 months presented for evaluation and management. An enhancing, infiltrative lesion in the left frontal lobe with underlying vasogenic edema was appreciated and suggestive of a primary or metastatic neoplasm. The patient underwent an open biopsy for further evaluation of the lesion. Extensive histopathologic evaluation revealed a diagnosis of T-cell PCNSL. The patient was started on induction methotrexate and temozolomide followed by consolidative radiotherapy. Conclusion: Autoimmune conditions are a risk factor for T-cell PCNSL development. T-cell PCNSL has radiographic and gross histologic features that are consistent with a broad differential, including gliomas and inflammatory processes. Prompt diagnosis and extensive histopathological evaluation is essential to ensure appropriate treatment.

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“…[ 4 - 6 , 13 , 29 , 32 ] T-cell PCNSL often presents as a single supratentorial lesion. [ 4 - 6 , 10 , 11 , 18 , 23 , 33 , 35 , 36 , 38 - 41 , 43 , 44 , 46 , 53 ]…”

Section: Discussionmentioning

confidence: 99%

Primary peripheral T-cell central nervous system lymphoma

Bird

Traylor

Thomas

et al. 2021

Surgical Neurology International

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“…To date, there have been approximately 36 well‐described cases of primary CNS T‐cell lymphoma in the literature and only seven of these were of suppressor cell phenotype 1–4 …”

Section: Discussionmentioning

confidence: 99%

A 33‐year‐old man with multiple ring‐enhancing lesions in the brain

Chandan¹,

Schelper²,

Shrimpton³

et al. 2006

Neuropathology

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A 33-year-old male presented with inability to think clearly and not recalling the death of his younger brother who had unexpectedly died a few days earlier. Prior to this episode the patient had enjoyed his usual good state of health and worked as a correctional officer with negative HIV history. His memory continued to decline and he had increased lethargy.On physical examination the patient was afebrile without lymphadenopathy, organomegaly or skin lesions. A neurological examination revealed no focal deficits. Laboratory studies were all within normal limits, including a normal complete blood count (CBC) without lymphocytosis or abnormal circulating lymphoid cells. MRI revealed several hemorrhagic ring-enhancing lesions in the brain: one in the right temporal lobe and two in the left temporal lobe, and one in the right occipital lobe (Fig. 1). No other lesions were found in the chest, abdominal or the pelvic regions. NEUROPATHOLOGICAL FINDINGSHematoxylin and eosin-stained sections of the stereotactic biopsy tissue showed a perivascular mononuclear cell infiltrate consisting of small lymphoid cells with round to oval hyperchromatic nuclei, inconspicuous nucleoli and scant cytoplasm ( Fig. 2A). Mitotic figures as well as apoptotic nuclei were also seen (Fig. 2B).Immunohistochemistry showed that a majority of the lymphoid cells were positive for leukocyte common antigen CD45, T-cell markers CD3 (Fig. 3A), CD8, and focally positive for CD7. Rare CD4 positive cells were present. Most lymphoid cells were negative for CD20 (Fig. 3B), CD79a, CD56, CD30, ALK and cytokeratin.

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Use of the Polymerase Chain Reaction to Detect B- and T-Cell Gene Rearrangements in Vitreous Specimens From Patients With Intraocular Lymphoma

White

Gascoyne²,

Paton³

1999

Arch Ophthalmol

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To determine whether the polymerase chain reaction for Band T-cell gene rearrangements could be applied to vitreous specimens to aid in the diagnosis of intraocular lymphoma. Methods: Vitreous washing specimens from 4 patients were received in balanced saline solution and centrifuged, and a portion of the pellet was used to make routine cytospins. The remainder was used to make a crude extract of DNA that was amplified for immunoglobulin heavy chain and T-cell receptor ␥ gene rearrangements and the 14;18 translocation by polymerase chain reaction. Results: One patient had 2 specimens 2 years apart. In each, there was an identical band corresponding to the minor cluster region breakpoint of the bcl-2 oncogene, indicating the presence of a 14;18 translocation. One patient showed an immunoglobulin heavy chain gene rearrangement indicating a B-cell lymphoma. Two patients showed rearrangements of the T-cell receptor ␥ gene, indicating the presence of a T-cell lymphoma. Conclusions and Clinical Relevance: Vitreous washing specimens can be used successfully to detect Band T-cell gene rearrangements by polymerase chain reaction. This may be useful to confirm the diagnosis of intraocular large cell lymphoma in cases suggestive of the diagnosis. Prompt handling of the specimens is necessary to prevent degradation of the DNA.

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Primary central nervous system T‐cell lymphoma with a predominant CD8 immunophenotype

Cited by 12 publications

References 40 publications

Primary peripheral T-cell central nervous system lymphoma

Primary peripheral T-cell central nervous system lymphoma

A 33‐year‐old man with multiple ring‐enhancing lesions in the brain

Use of the Polymerase Chain Reaction to Detect B- and T-Cell Gene Rearrangements in Vitreous Specimens From Patients With Intraocular Lymphoma

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