Primary central nervous system tumors in stillborns and infants

Jänisch, W; Haas, Joanna F.; Schreiber, D; Gerlach, H

doi:10.1007/bf00177895

Cited by 41 publications

(16 citation statements)

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“…In 1973, Jellinger and Sunder-Plassmann [2] proposed the following classification of congenital brain tumors: definitely congenital, presentation at birth or within 2 weeks of life; probably congenital, within 1 year of life; and possibly congenital, beyond 1 year of life. Various pediatric series have consistently reported grade I–III astrocytomas as the second most common intracranial congenital neoplasms, following medulloblastoma, teratomas or primitive neuroectodermal tumors [1, 3]. Glioblastoma, in contrast, is extremely rare.…”

Section: Discussionmentioning

confidence: 99%

“…Congenital primary brain tumors are rare and carry an estimated incidence of 1.1–3.6 per 100,000 newborns [1]. In 1973, Jellinger and Sunder-Plassmann [2] proposed the following classification of congenital brain tumors: definitely congenital, presentation at birth or within 2 weeks of life; probably congenital, within 1 year of life; and possibly congenital, beyond 1 year of life.…”

Section: Discussionmentioning

confidence: 99%

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Congenital Glioblastoma Multiforme: Case Report and Review of the Literature

Hou¹,

Bababeygy²,

Sarkissian³

et al. 2008

Pediatr Neurosurg

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Congenital glioblastoma multiforme is a rare primary brain tumor that has a unique biology distinct from pediatric and adult variants. In this report, we present a case of congenital glioblastoma with complicated management course. A literature review of previously reported cases is included to illustrate the epidemiology and natural history of this disease. A 9-month-old male infant developed acute lethargy, hemiparesis and unilaterally dilated pupil. Imaging studies revealed a large hemispheric tumor, resulting in significant midline shift suggestive of impending herniation. Emergent tumor cystic fluid drainage was performed at initial presentation. A frontotemporoparietal craniotomy was performed on the following day to attempt a gross total resection. Adjuvant chemotherapy consisting of oral temozolomide was administered. The patient eventually succumbed 4 months later due to aggressive tumor progression. Congenital glioblastoma should be included in the differential diagnosis of infants with large intracranial tumors. Although surgical intervention may increase survival, the overall outcome remains poor despite maximal multimodal treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Congenital Glioblastoma Multiforme: Case Report and Review of the Literature

Hou¹,

Bababeygy²,

Sarkissian³

et al. 2008

Pediatr Neurosurg

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“…1 Congenital brain tumors are rare, with an incidence of 3.6 to 4.1 per 100 000 births. [2][3][4] There are no consensus definitions for "congenital" brain tumors. Jellinger and Sunder-Plassmann 5 proposed a classification system for definitions of "congenital": definitely congenital, producing symptoms at birth or within the first 2 weeks of life; probably congenital, producing symptoms in the first year of life; and possibly congenital, producing symptoms beyond the first year of life.…”

Section: Anaplastic Astrocytomas and Glioblastomas (World Healthmentioning

confidence: 99%

Case Report of Spontaneous Resolution of a Congenital Glioblastoma

et al. 2016

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Dr Davis collected the patient data, conducted the literature review, drafted the initial manuscript, and edited the manuscript according to feedback of the other authors; Dr Ziegler conceptualized and designed the project, provided feedback, and reviewed and revised the manuscript; Ms Doyle created the histopathology fi gures and legends and critically reviewed the manuscript; Ms Tobias analyzed and reported on the original slides, approved the histopathology fi gures and legends, and critically reviewed the manuscript; Dr Ellison reviewed the histopathology to assist with confi rmation of the diagnosis, undertook molecular analysis of the tumour, and revised the manuscript; and all authors approved the fi nal manuscript as submitted.

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“…Brain tumors occur ring in children under 2 years are more common than usually thought and differ in location, histology, and out come from tumors occurring in older children [ 1 -8] eral large series have found that 11-16% of childhood brain tumors occur in children less than 2 years of age [1][2][3][4], Supratentorial tumors predominate in younger children. A Scandinavian study of deaths in the first year of life, including stillborn deliveries, revealed the inci dence of brain tumors to be 1.1/100.000 births [9], The incidence of brain tumors in children under 16 years of age is generally accepted to be 2 -3 /100.000. which sug gests that many tumors develop early in life [10], Al though the same spectrum of pathology occurs in infants and older children, infants have a disproportionately large incidence of chiasmatic-hypothalamic gliomas (CHG), choroid plexus tumors, and malignant congenital or embryonal tumors.…”

Section: Introductionmentioning

confidence: 99%

Brain Tumors in Children under 2 Years: Treatment, Survival and Long-Term Prognosis

Cohen

Packer

Siegel³

et al. 1993

Pediatr Neurosurg

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Survival for children with brain tumors less than 2 years of age at diagnosis is dismal, and the quality of life of long-term survivors poor. Between 1975 and 1987, 78 (13%) of 579 patients with brain tumors treated at Children’s Hospital of Philadelphia were under 2 years of age. Tumor site was posterior fossa in 31 (40%) and supratentorial in 47 (60%). Nine of 37 patients (24%) with malignant tumors, and 30 of 41 (73%) patients with benign tumors are alive with a mean follow-up of 116 months. Long-term survival after treatment with chemotherapy alone occurred in 10 patients, including 3 with malignant tumors. In 5 additional patients, chemotherapy delayed the need for irradiation a mean of 30 months. Of the 29 patients who relapsed after initial therapy, 12 are alive without progressive disease (2 patients with malignant tumors and 10 with benign tumors) a mean of 80 months after relapse, 2 children are alive with progressive disease, and 14 died a median of 48 months (range 9–115 months) after relapse. Twenty-one of the 39 survivors have minimal or no neurological or intellectual dysfunction. Surviving patients treated with surgery and chemotherapy have better intellectual function than patients treated with surgery and radiation (with or without chemotherapy) in that 8 of 10 children treated with surgery and chemotherapy have normal or above normal intelligence compared with 5 of 12 children receiving irradiation before their second birthday.

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Primary central nervous system tumors in stillborns and infants

Cited by 41 publications

References 0 publications

Congenital Glioblastoma Multiforme: Case Report and Review of the Literature

Congenital Glioblastoma Multiforme: Case Report and Review of the Literature

Case Report of Spontaneous Resolution of a Congenital Glioblastoma

Brain Tumors in Children under 2 Years: Treatment, Survival and Long-Term Prognosis

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