Primary cerebellopontine angle angiosarcoma

Zhai, Guangju; Pang, Qi; Guo, Hua; Xu, Shulan; Wang, Hanbin

doi:10.1016/j.jocn.2006.11.018

Cited by 16 publications

(34 citation statements)

References 24 publications

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“…The clinical manifestations of these tumors are related to their anatomical sites in the CNS and frequently act like a space‐occupying lesion, producing focal symptoms when in eloquent areas along with raised intracranial pressure syndrome. The clinical course of brain angiosarcoma may be characterized by the rapid onset or abrupt aggravation of symptoms due to intra‐lesional and extra‐lesional hemorrhage (18 out of 31 cases) …”

Section: Discussionmentioning

confidence: 99%

Primary central nervous system angiosarcoma: A case report and literature review

et al. 2014

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Angiosarcoma is a rare vascular malignant neoplasm that mainly occurs in skin and soft tissues. Intracranial localization is very rare and only a few cases have been reported. This report intends to present the clinical, radiological and pathological pictures of a primary central nervous system angiosarcoma along with a review of the literature. A 35-year-old woman presented at our institution with weakness and sensory disturbances of her right hand. Neuroimaging revealed a roughly round, hemorrhagic and moderately enhancing lesion in the left frontal posterior region. The tumor was totally removed under awake anesthesia and continuous monitoring of motor and language functions. Histopathology revealed an epithelioid angiosarcoma. Radical removal, followed by adjuvant radiotherapy and chemotherapy, is able to completely control the disease for a relatively long period.

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Section: Discussionmentioning

confidence: 99%

Primary central nervous system angiosarcoma: A case report and literature review

et al. 2014

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“…Clinical symptoms, course of illness, and brain CT findings of angiosarcoma can easily masquerade as a bleed 21 , 22. Therefore, clinicians and radiologists should be aware of this potentially significant differential diagnosis 23. Our case was challenging as smaller metastatic angiosarcomatous lesions, which were reported on the follow-up CT scan, were not distinguishable until the probable primary lesion became fully evident on the scalp.…”

Section: Discussionmentioning

confidence: 89%

Metastatic angiosarcoma: a vascular tumour or an intracranial haemorrhage?

Masih

McIlwaine²

2010

Case Reports

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A 64-year-old man presented with weakness of his right arm and leg. He had previously had mitral valve replacement, tricuspid annuloplasty, leg deep vein thrombosis (DVT) and femoral embolism. Computed tomography (CT) scan of the brain showed an acute left thalamic haemorrhage. Repeat CT brain showed resolution of the original haemorrhage, but the apparent development of new areas of haemorrhage. Warfarin continued due to high risk of thromboembolism. He was readmitted with the rapid development of a visible swelling at the sternum and on the scalp. Ultrasound scan of the sternum revealed a vascular tumour. Suspected haemorrhages in the past were reported as the metastatic deposits. Biopsy and immunohistochemical staining confirmed angiosarcoma of the scalp. Being vascular tumours, angiosarcoma can mimic a brain haemorrhage. Our case illustrates a clinical conundrum. Diagnosing metastatic angiosarcoma of the brain proved difficult without visible primary and histology. The rapid clinical course of the disease and problems with anticoagulation therapy made treatment options limited and the prognosis worse.

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“…On imaging these appear as well demarcated lesions with haemorrhagic characteristics 1. However the non-specific imaging appearances render preoperative diagnosis of primary intracranial angiosarcoma extremely difficult.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, cellular atypia, as well as many mitoses and necrosis, are histological characteristics often attributed to angiosarcomas. Immunohistochemical studies, including assays for factor CD31, CD34, factor-related antigen and Ulex europaeus , are necessary to identify the endothelial nature of the neoplastic cells 1 9 11. These are useful for differentiating angiosarcoma from meningeal hemangiopericytoma, anaplastic gliomas, metastatic carcinoma, amelanotic melanoma, hemangioblastoma and several other highly vascular sarcomas 9…”

Section: Discussionmentioning

confidence: 99%

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Tumour bleed manifesting as spontaneous extradural haematoma in posterior fossa

Mahore¹,

Ramdasi²,

Pauranik³

et al. 2014

BMJ Case Reports

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We report a unique case of primary extradural angiosarcoma of posterior fossa manifesting as extradural haematoma in a 12-year-old boy who presented with acute onset headache, vomiting, nuchal rigidity and altered sensorium. The patient underwent a retromastoid suboccipital craniotomy on emergency basis, and the lesion was excised completely. Histopathology and immunohistochemistry revealed an angiosarcoma, following which radiation therapy was given. The patient showed complete clinical and neurological improvement. At a follow-up of 2 years he is in good health without any sign of regrowth.

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Primary cerebellopontine angle angiosarcoma

Cited by 16 publications

References 24 publications

Primary central nervous system angiosarcoma: A case report and literature review

Primary central nervous system angiosarcoma: A case report and literature review

Metastatic angiosarcoma: a vascular tumour or an intracranial haemorrhage?

Tumour bleed manifesting as spontaneous extradural haematoma in posterior fossa

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