Primary cervical choriocarcinoma: report of four cases and literature review

Fu, Yunfeng; Lü, Weiguo; Zhou, Caiyun; Xie, Xing

doi:10.1111/j.1525-1438.2007.00819.x

Cited by 8 publications

(5 citation statements)

References 7 publications

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“…However, the overall incidence of choriocarcinoma in recent years has been decreased parallel to improving socioeconomic conditions [13]. Primary choriocarcinoma of the cervix is an extremely rare disease; however, most of the case reports in literatures demonstrate that extrauterine choriocarcinoma mostly originates in cervix rather than other sites in genital tract [2][3][4][5][6][7]. Our case fulfilled the criteria defined by Saito et al [1].…”

Section: Discussionsupporting

confidence: 53%

“…Saito et al defined following diagnostic criteria for extrauterine choriocarcinoma in 1965: 1) absence of disease in the uterine cavity, 2) exclusion of coexistence of normal intrauterine pregnancy, 3) exclusion of molar pregnancy and 4) pathologic confirmation of disease [1]. Most of the extrauterine choriocarcinoma reported in literature, originates in uterine cervix [2][3][4][5][6][7]. However, there are also reports in the literature that choriocarcinoma located in other regions outside the uterus in genital tract such as ovary [8], tube [9], vulva [10] and vagina [11].…”

Section: Introductionmentioning

confidence: 99%

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Primary Cervical Choriocarcinoma: Case Report and the Review of Literatures

Behtash¹,

Zarchi²,

Shamshirsaz³

et al. 2013

JCT

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Background: Primary choriocarcinoma of the cervix is a very rare entity. Case: A 35-year-old patient had been admitted to our hospital with vaginal bleeding for 7 months. A cervical mass measured 4 × 4 cm was palpated on the anterior surface of the cervix. Biopsy of the lesion demonstrated extensive necrosis and was in favor of squamous cell carcinoma. Patient was accepted as FIGO stage I b1-2 and underwent type II hysterectomy with bilateral salpingoopherectomy and bilateral pelvic lymph node dissection was carried out. Post operative pathologic evaluation of the surgical specimen evinced that the case was primary cervical choriocarcinoma. Conclusion: Primary choriocarcinoma of the cervix should be considered in patients in their reproductive years with cervical lesion and negative cervical cytology. Beta-hCG assay and transvaginal color Doppler sonography are useful for early diagnosis.

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Section: Discussionsupporting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Primary Cervical Choriocarcinoma: Case Report and the Review of Literatures

Behtash¹,

Zarchi²,

Shamshirsaz³

et al. 2013

JCT

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“…Choriocarcinoma of the uterine cervix is rarer in the USA and Europe than in Asia, Africa and Latin America . According to the English‐language literature, approximately 80 cases have been reported, and most of these cases have followed pregnancy . Including the current case, only two cases have been diagnosed during pregnancy…”

Section: Discussionmentioning

confidence: 88%

“…5 According to the English-language literature, approximately 80 cases have been reported, and most of these cases have followed pregnancy. 6 Including the current case, only two cases have been diagnosed during pregnancy. 7 Although it is not unprecedented, it is not common to find a cervical mass away from the placenta in pregnant women.…”

Section: Discussionmentioning

confidence: 94%

Primary cervical choriocarcinoma during viable intrauterine pregnancy

Park¹,

Han²,

Lee³

et al. 2015

J of Obstet and Gynaecol

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A 31-year-old multigravida woman at 27 weeks' gestation was admitted with vaginal bleeding and a hypervascular mass near the cervix on ultrasonography. After discharge with improvement, she was readmitted the next day for uncontrolled, heavy vaginal bleeding and underwent emergency cesarean section at 29 weeks' gestation. A 3-cm friable mass found near the cervix was removed surgically; this lesion was shown to be primary cervical choriocarcinoma. On the 17th postoperative day the patient underwent total abdominal hysterectomy with preservation of both ovaries and biopsy was performed on the right ovary. The International Federation of Gynecology and Obstetrics (FIGO) stage was I and her World Health Organization prognostic score was 9, representing high risk. The patient received three rounds of chemotherapy until achieving three consecutive normal human chorionic gonadotropin levels with two additional courses to address risk of relapse. DNA genotyping on short tandem repeat polymorphism confirmed the gestational choriocarcinoma.

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“…Primary cervical GTN is an extremely rare type of ectopic GTN that is difficult to clinically diagnose because of its rarity; non-specific abnormal vaginal bleeding is the most common symptom [2]. This disease can also mimic other, more common, cervical lesions such as cervical pregnancy, threatened abortion, cervical polyp, or cervical neoplasia.…”

Section: Introductionmentioning

confidence: 99%

Identification and treatment of primary cervical gestational trophoblastic neoplasia: a retrospective study of 13 patients and literature review

Wang

Yang

Wan

et al. 2021

Orphanet J Rare Dis

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Background Primary cervical gestational trophoblastic neoplasias (GTNs) are extremely rare ectopic GTNs. Such lesions are difficult to diagnose clinically because of their rarity, with abnormal vaginal bleeding of a non-specific cause being the most common symptom. To that end, this retrospective study aimed to identify the clinical characteristics of cervical GTN and to explore diagnostic and therapeutic strategies. Results Thirteen patients diagnosed with primary cervical GTN at the Department of Gynecology, Peking Union Medical College Hospital, Beijing, China, between June 1, 1988 and May 31, 2020 were included in the study. All patients had irregular vaginal bleeding, including six who presented with massive bleeding. Seven patients (53.8%) were initially misdiagnosed with a cervical pregnancy. All patients received chemotherapy; 11 (84.6%) also underwent hysterectomy because of chemoresistant lesions or uncontrolled bleeding. All patients achieved complete remission; however, two women (15.4%) experienced a relapse during the median follow-up period of 35 months. A comprehensive review of English-language literature published between 1980 and 2020 identified 22 case reports encompassing 27 patients. The definitive diagnosis was achieved via pathology in 26 of them (96.3%), and hysterectomy was performed in 21 (77.8%). Conclusions Owing to its rarity and nonspecific symptoms, the diagnosis of primary cervical GTN is challenging and often relies on pathology. The combination of chemotherapy and hysterectomy is the main therapeutic strategy for this disease.

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Primary cervical choriocarcinoma: report of four cases and literature review

Cited by 8 publications

References 7 publications

Primary Cervical Choriocarcinoma: Case Report and the Review of Literatures

Primary Cervical Choriocarcinoma: Case Report and the Review of Literatures

Primary cervical choriocarcinoma during viable intrauterine pregnancy

Identification and treatment of primary cervical gestational trophoblastic neoplasia: a retrospective study of 13 patients and literature review

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