Primary Chief Cell Hyperplasia of the Parathyroid Glands

Idiopathic Hypercalciuria and Hyperparathyroidism

“…5 and 6. The patient without hypercalcaemia had primary chief cell hyperplasia (Adams et al, 1965), which was treated by total parathyroidectomy; a relative suffered from the same condition. One of the patients who developed hypercalcaemia had (Fig.…”

Familial hyperparathyroidism

“…Tihe affected members, II 1, II 3 and II 5, were all female and all suffered from primary chief cell hyperplasia of the parathyroids. Brief clinical details are recorded in the appendix; the cases are reported at greater length elsewhere (Adams, Chalmers, Peters, Rack -and Truscott, 1965). Serum calcium* and in some cases serum phosphate and alkaline phosphatase estimations were carried out on eight other members of the family (Table 1).…”

Genetics of Urolithiasis

“…No specific gene defect in autosomal dominant parathyroid adenomas has been identified. Familial hyperparathyroidism has also been associated with chief-cell hyperplasia [53]. It is unclear whether this autosomal dominant condition is truly distinct from parathyroid adenomas.…”